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- Publications
- Influence
Preparation, characterization and properties of sterically stabilized paclitaxel-containing liposomes.
- P. Crosasso, M. Ceruti, P. Brusa, S. Arpicco, F. Dosio, L. Cattel
- Medicine
- Journal of controlled release : official journal…
- 3 January 2000
Paclitaxel (Taxol) is a diterpenoid isolated from Taxus brevifolia, approved by the FDA for the treatment of ovarian and breast cancers. Due to its low solubility in water, it is clinically… Expand
Preparation, characterization, cytotoxicity and pharmacokinetics of liposomes containing lipophilic gemcitabine prodrugs.
- M. Immordino, P. Brusa, F. Rocco, S. Arpicco, M. Ceruti, L. Cattel
- Chemistry, Medicine
- Journal of controlled release : official journal…
- 10 December 2004
Gemcitabine is a known anticancer agent rapidly deaminated to the inactive metabolite 2',2'-difluorodeoxyuridine; it must therefore be administered at very high dose. Many different approaches have… Expand
An NMR and molecular mechanics study of squalene and squalene derivatives.
- L. Pogliani, M. Ceruti, G. Ricchiardi, D. Viterbo
- Chemistry, Medicine
- Chemistry and physics of lipids
- 31 March 1994
Various squalene derivatives, including squalene, squalene 2,3-epoxide (monoepoxide, SQME), squalene 2,3;22,23-diepoxide (SQDE), 2-aza-2,3-dihydrosqualene (SQN) and 2-aza-2,3-dihydrosqualene N-oxide… Expand
From Conventional to Stealth Liposomes a new Frontier in Cancer Chemotherapy
Many attempts have been made to achieve good selectivity to targeted tumor cells by preparing specialized carrier agents that are therapeutically profitable for anticancer therapy. Among these,… Expand
Characterization and partial purification of squalene-2,3-oxide cyclase from Saccharomyces cerevisiae.
- G. Balliano, F. Viola, M. Ceruti, L. Cattel
- Biology, Medicine
- Archives of biochemistry and biophysics
- 14 February 1992
The membrane nature of squalene oxide cyclase from Saccharomyces cerevisiae was investigated by comparing properties of the enzyme recovered from both microsomes and the soluble fraction of the yeast… Expand
Interaction of lipophilic gemcitabine prodrugs with biomembrane models studied by Langmuir-Blodgett technique.
- F. Castelli, M. G. Sarpietro, F. Rocco, M. Ceruti, L. Cattel
- Chemistry, Medicine
- Journal of colloid and interface science
- 1 September 2007
The stability and bioavailability of anticancer agents, such as gemcitabine, can be increased by forming prodrugs. Gemcitabine is rapidly deaminated to the inactive metabolite… Expand
Preparation, characterization, cytotoxicity and pharmacokinetics of liposomes containing water-soluble prodrugs of paclitaxel.
- M. Ceruti, P. Crosasso, P. Brusa, S. Arpicco, F. Dosio, L. Cattel
- Chemistry, Medicine
- Journal of controlled release : official journal…
- 3 January 2000
Paclitaxel (Taxol) is a diterpenoid isolated from Taxus brevifolia, used clinically for the treatment of ovarian and breast cancer. Due to its aqueous insolubility it is administered dissolved in… Expand
Pharmacokinetic monitoring of mycophenolate mofetil in kidney transplanted patients.
Mycophenolate mofetil (MMF) is a new immunosuppressant drug used in association with cyclosporin and oral corticosteroids to prevent acute rejection following renal allograft transplantation. MMF is… Expand
Characterization of lipophilic gemcitabine prodrug-liposomal membrane interaction by differential scanning calorimetry.
- F. Castelli, M. G. Sarpietro, M. Ceruti, F. Rocco, L. Cattel
- Chemistry, Medicine
- Molecular pharmaceutics
- 25 October 2006
Gemcitabine is an anticancer agent rapidly deaminated to the inactive metabolite 2',2'-difluorodeoxyuridine. Its stability as well as bioavailability can be increased by making prodrugs. A series of… Expand
Conjugation of squalene to acyclovir improves the affinity for biomembrane models.
- M. G. Sarpietro, D. Micieli, F. Rocco, M. Ceruti, F. Castelli
- Medicine, Chemistry
- International journal of pharmaceutics
- 1 December 2009
Differential scanning calorimetry was used to study the interaction of acyclovir and its prodrug squalenoyl-acyclovir (obtained by conjugation of 1,1',2-tris-nor-squalene acid (squaleneCOOH) with… Expand