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The cytoprotective protein C pathway.
This review summarizes insights gleaned from recent in vitro and in vivo studies of the direct cytoprotective effects of APC that include beneficial alterations in gene expression profiles, anti-inflammatory actions, antiapoptotic activities, and stabilization of endothelial barriers that suggest the possibility of developing APC variants with an improved profile for the ratio of cy toprotective to anticoagulant actions.
Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective
It is reported that APC directly prevents apoptosis in hypoxic human brain endothelium through transcriptionally dependent inhibition of tumor suppressor protein p53, normalization of the pro-apoptotic Bax/Bcl-2 ratio and reduction of caspase-3 signaling.
Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46.
In vitro and in vivo data imply that the novel PAR1 N-terminus beginning at residue Asn47, which is generated by APC cleavage at Arg46, mediates APC's cytoprotective signaling and that this unique APC-generated N-Terminal peptide tail is a novel biased agonist for PAR1.
Endothelial and antithrombotic actions of HDL.
There is evidence of a variety of mechanisms by which HDL is antithrombotic and thereby protective against arterial and venous thrombosis, including through the activation of prostacyclin synthesis.
Protein synthesis by native chemical ligation: expanded scope by using straightforward methodology.
A straightforward methodology that has enabled us to rapidly analyze the compatibility of the native chemical ligation strategy for X-Cys ligation sites, where X is any of the 20 naturally occurring amino acids, and shows that all 20 amino acids are suitable for ligation.
Discovery of a fusion kinase in EOL-1 cells and idiopathic hypereosinophilic syndrome
A genetic rearrangement in the eosinophilic cell line EOL-1 is identified that results in the expression of a fusion protein comprising an N-terminal region encoded by a gene of unknown function with the GenBank accession number NM_030917 and a C-Terminal region derived from the intracellular domain of the platelet-derived growth factor receptor α (PDGFRα).