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Systematic analysis of yeast strains with possible defects in lipid metabolism
TLDR
A group of five European laboratories established methods suitable to screen for novel genes of the yeast Saccharomyces cerevisiae involved in lipid metabolism, regulation of lipid biosynthesis and the role of lipids in organellar membranes, and found evidence suggesting a possible role in cholesterol metabolism.
Antioxidant systems in rat epididymal spermatozoa.
TLDR
In vitro peroxidation of the two sperm populations by the free radical generator 2,2'-azobis(2-amidinopropane) dihydrochloride revealed that only about 13% of the vitamin E content of the caput epididymidal spermatozoa was consumed, which contrasts with the greater consumption (about 70%) of the Vitamin E content in cauda epididylitezoa.
Squalenoyl nanomedicines as potential therapeutics.
TLDR
The squalenoylation of gemcitabine and other antiretroviral nucleosides led to more potent drugs when tested in primary cultures of HIV-infected lymphocytes and in vivo in experimental leukemia both after intravenous and oral administration.
Subcellular localization of oxidosqualene cyclases from Arabidopsis thaliana, Trypanosoma cruzi, and Pneumocystis carinii expressed in yeast
TLDR
Computer analysis supports the hypothesis of the structural difference since OSC from S. cerevisiae, A. thaliana, and T. carinii differ in some structural features critical for the interaction with the surface of lipid particles.
Antitumor activity and pharmacokinetics of liposomes containing lipophilic gemcitabine prodrugs.
TLDR
The incorporation of C18gem-prodrug in liposomes increased the plasma half life of the drug resulting in increased accumulation in the tumor cells and a higher level of antitumoral efficacy.
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