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organ dysfunction syndrome

National Institutes of Health

Papers overview

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Review
2012
Review
2012
Gut-origin sepsis: evolution of a concept.
Highly Cited
2010
Highly Cited
2010
Daily estimation of the severity of multiple organ dysfunction syndrome in critically ill children
Background: Daily evaluation of multiple organ dysfunction syndrome has been performed in critically ill adults. We evaluated the… 
Highly Cited
2003
Highly Cited
2003
Chronic alcohol abuse is associated with an increased incidence of acute respiratory distress syndrome and severity of multiple organ dysfunction in patients with septic shock
ObjectiveAlcohol is one of the most commonly used drugs in the world and causes dysfunction in many vital organs. However, the… 
Highly Cited
2003
Highly Cited
2003
The two faces of IKK and NF-κB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion
We studied the role of NF-κB in acute inflammation caused by gut ischemia-reperfusion through selective ablation of IκB kinase… 
Highly Cited
2002
Highly Cited
2002
Anti-c5a ameliorates coagulation/fibrinolytic protein changes in a rat model of sepsis.
Review
2000
Review
2000
Multiple organ dysfunction syndrome: Exploring the paradigm of complex nonlinear systems
Objectives The objectives of this article are to introduce and explore a novel paradigm based on complex nonlinear systems, and… 
Highly Cited
1999
Highly Cited
1999
Melatonin inhibits expression of the inducible NO synthase II in liver and lung and prevents endotoxemia in lipopolysaccharide‐induced multiple organ dysfunction syndrome in rats
We evaluated the role of melatonin in endotoxemia caused by lipopolysaccharide (LPS) in unanesthetized rats. The expression of… 
Review
1998
Review
1998
SYSTEMIC INFLAMMATORY RESPONSE SYNDROME (SIRS), MULTIPLE ORGAN DYSFUNCTION SYNDROME (MODS), MULTIPLE ORGAN FAILURE (MOF): ARE WE WINNING THE BATTLE?
The problems of inflammation and infection leading to organ dysfunction and failure continue to be the major problems after… 
Review
1996
Review
1996
Uncoupling of biological oscillators: a complementary hypothesis concerning the pathogenesis of multiple organ dysfunction syndrome.
OBJECTIVE To present a complementary hypothesis concerning the pathogenesis of the multiple organ dysfunction syndrome. DATA… 
Highly Cited
1995
Highly Cited
1995
The cell wall components peptidoglycan and lipoteichoic acid from Staphylococcus aureus act in synergy to cause shock and multiple organ failure.
Although the incidence of Gram-positive sepsis has risen strongly, it is unclear how Gram-positive organisms (without endotoxin… 
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