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Sepsis and septic shock--a review of laboratory models and a proposal.
Abstract Study of the pathophysiology of infection requires the use of animal models in order to separate the many variables. Meaningful controlled studies of septic patients are difficult because of… Expand
SYSTEMIC INFLAMMATORY RESPONSE SYNDROME (SIRS), MULTIPLE ORGAN DYSFUNCTION SYNDROME (MODS), MULTIPLE ORGAN FAILURE (MOF): ARE WE WINNING THE BATTLE?
The problems of inflammation and infection leading to organ dysfunction and failure continue to be the major problems after injury and operations and with intensive care for many diseases and… Expand
Multiple organ failure in polytrauma patients.
To determine limitations in survival and problems of single and multiple organ failure (SOF, MOF) following trauma in Bavaria, we reviewed 433 consecutive patients with multiple injuries treated at… Expand
Multiple organ failure in trauma patients.
- R. Durham, John Moran, J. Mazuski, M. Shapiro, A. Baue, L. Flint
- The Journal of trauma
- 1 October 2003
SUMMARY BACKGROUND As care of the critically ill patient has improved and definitions of organ failure have changed, it has been observed that the incidence of organ failure and the mortality… Expand
MOF, MODS, and SIRS: what is in a name or an acronym?
- A. Baue
- 1 November 2006
The most prominent contributions to multiple organ failure, multiple organ dysfunction syndrome, and systemic inflammatory response syndrome are described in this article. However, it is quite… Expand
Evaluation of factors affecting mortality rate after sepsis in a murine cecal ligation and puncture model.
A murine model was used to test the effects of various therapeutic modalities on the rate of death following intra-abdominal sepsis as produced by cecal ligation and puncture (CLP). There were no… Expand
T-cell reactivity and its predictive role in immunosuppression after burns.
OBJECTIVE To obtain further insight into the constitutional, phenotype-dependent changes of T-helper-1 and T-helper-2 signature lymphokine synthesis after trauma. DESIGN Prospective, descriptive… Expand
Effect of sepsis on tissue adenine nucleotide levels.
Tissue adenine nucleotides were measured in rats to determine if there is depletion of energy stores associated with sepsis. Peritonitis was produced by cecal ligation and cecal puncture. At 16 to 24… Expand
Hemorrhage without tissue trauma produces immunosuppression and enhances susceptibility to sepsis.
To determine whether hemorrhage without major tissue trauma can itself produce immunosuppression, the effect of hemorrhage on the lymphocyte response to T-cell mitogen in endotoxin-resistant C3H/HEJ… Expand
The use of oxygen consumption and delivery as endpoints for resuscitation in critically ill patients.
OBJECTIVE Oxygen consumption (VO2I) and delivery (DO2I) indices have been stated to be superior to conventional parameters as endpoints for resuscitation. However, another interpretation of published… Expand