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Immunity, Inflammation, and Cancer
The principal mechanisms that govern the effects of inflammation and immunity on tumor development are outlined and attractive new targets for cancer therapy and prevention are discussed. Expand
Mammalian MAP kinase signalling cascades
Recent studies have begun to shed light on the physiological functions of MAPK cascades in the control of gene expression, cell proliferation and programmed cell death. Expand
Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity.
Recent progress has been made in understanding the details of the signaling pathways that regulate NF-kappaB activity, particularly those responding to the proinflammatory cytokines tumor necrosis factor-alpha and interleukin-1. Expand
A central role for JNK in obesity and insulin resistance
It is shown that JNK activity is abnormally elevated in obesity and an absence of JNK1 results in decreased adiposity, significantly improved insulin sensitivity and enhanced insulin receptor signalling capacity in two different models of mouse obesity. Expand
Gene Expression
Subjects’ peripheral blood mononuclear cells were analyzed to examine global gene expression. This molecular approach was used to distinguish between CFS cases, subjects who meet the CFS researchExpand
Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases.
In chronic inflammatory diseases, such as asthma, rheumatoid arthritis, inflammatory bowel disease, and psoriasis, several cytokines recruit activated immune and inflammatory cells to the site ofExpand
Regulation and function of NF-kappaB transcription factors in the immune system.
Much progress has been made in the past two years revealing new insights into the regulation and functions of NF-kappaB, and this recent progress is covered in this review. Expand
AP-1 function and regulation.
This work has shown that regulation by heterodimerization between Jun, Fos and ATF proteins, AP-1 activity is regulated through interactions with specific protein kinases and a variety of transcriptional coactivators, and there has been considerable progress in understanding some of the mechanisms and signaling pathways involved in the regulation of AP. Expand
AP-1 as a regulator of cell life and death
Interestingly, the growth-promoting activity of c-Jun is mediated by repression of tumour suppressors, as well as upregulation of positive cell cycle regulators, whereas JunB has the converse effect. Expand