The cell wall components peptidoglycan and lipoteichoic acid from Staphylococcus aureus act in synergy to cause shock and multiple organ failure.

@article{Kimpe1995TheCW,
  title={The cell wall components peptidoglycan and lipoteichoic acid from Staphylococcus aureus act in synergy to cause shock and multiple organ failure.},
  author={Sjef J. de Kimpe and Muralitharan Kengatharan and Christoph Thiemermann and John R. Vane},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 22},
  pages={10359-63}
}
Although the incidence of Gram-positive sepsis has risen strongly, it is unclear how Gram-positive organisms (without endotoxin) initiate septic shock. We investigated whether two cell wall components from Staphylococcus aureus, peptidoglycan (PepG) and lipoteichoic acid (LTA), can induce the inflammatory response and multiple organ dysfunction syndrome (MODS) associated with septic shock caused by Gram-positive organisms. In cultured macrophages, LTA (10 micrograms/ml), but not PepG (100… CONTINUE READING
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Handbook of Shock and Trauma (Raven, New York)

  • B. M. Altura
  • 1983

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