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MicroRNA-145, a Novel Smooth Muscle Cell Phenotypic Marker and Modulator, Controls Vascular Neointimal Lesion Formation
Phenotypic modulation of vascular smooth muscle cells (VSMCs) plays a critical role in the pathogenesis of a variety of proliferative vascular diseases. Recently, we have found that microRNA (miRNA)… Expand
Multiple organ failure. Pathophysiology and potential future therapy.
- E. Deitch
- Annals of surgery
- 1 August 1992
Multiple organ failure (MOF) has reached epidemic proportions in most intensive care units and is fast becoming the most common cause of death in the surgical intensive care unit. Furthermore, in… Expand
Hypertrophic burn scars: analysis of variables.
- E. Deitch, T. M. Wheelahan, M. P. Rose, J. Clothier, J. Cotter
- The Journal of trauma
- 1 October 1983
A major problem in patients surviving thermal injury is the development of hypertrophic burn scars. The current study was performed to determine the factors associated with an increased risk of the… Expand
Role of the Gut in Multiple Organ Failure: Bacterial Translocation and Permeability Changes
Abstract. It is clear that increased gut permeability and bacterial translocation play a role in multiple organ failure (MOF). Failure of the gut barrier remains central to the hypothesis that toxins… Expand
ANIMAL MODELS OF SEPSIS AND SHOCK: A REVIEW AND LESSONS LEARNED
- E. Deitch
- 1 January 1998
Over the past decade, the biotechnology/pharmaceutical industry has been diligently working on the development of immunomodulatory agents for the treatment of shock and sepsis, and the literature is… Expand
Adenosine inhibits IL‐12 and TNF‐α production via adenosine A2a receptor‐dependent and independent mechanisms
- G. Haskó, D. Kuhel, +5 authors C. Szabo
- Chemistry, Medicine
- FASEB journal : official publication of the…
- 1 October 2000
Interleukin 12 (IL‐12) is a crucial cytokine in the regulation of T helper 1 vs. T helper 2 immune responses. In the present study, we investigated the effect of the endogenous purine nucleoside… Expand
American Burn Association Consensus Conference to Define Sepsis and Infection in Burns
- D. Greenhalgh, J. Saffle, +20 authors B. Latenser
- Journal of burn care & research : official…
- 1 November 2007
Because of their extensive wounds, burn patients are chronically exposed to inflammatory mediators. Thus, burn patients, by definition, already have “systemic inflammatory response syndrome.” Current… Expand
Isolated traumatic brain injury: age is an independent predictor of mortality and early outcome.
BACKGROUND Geriatric trauma patients have a worse outcome than the young with comparable injuries. The contribution of traumatic brain injury (TBI) to this increased mortality is unknown and has been… Expand
Gut lymph and lymphatics: a source of factors leading to organ injury and dysfunction
- E. Deitch
- Annals of the New York Academy of Sciences
- 1 October 2010
Major trauma, shock, sepsis, and other conditions can lead to the acute respiratory distress syndrome (ARDS), which may progress to the highly lethal multiple organ dysfunction syndrome (MODS).… Expand
Role of the gut in the development of injury- and shock induced SIRS and MODS: the gut-lymph hypothesis, a review.
It has long been recognized that major trauma, shock, or burn injury can lead to an acute systemic inflammatory state (SIRS) as well as the multiple organ dysfunction syndrome (MODS). Because of the… Expand