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MicroRNA-145, a Novel Smooth Muscle Cell Phenotypic Marker and Modulator, Controls Vascular Neointimal Lesion Formation
Phenotypic modulation of vascular smooth muscle cells (VSMCs) plays a critical role in the pathogenesis of a variety of proliferative vascular diseases. Recently, we have found that microRNA (miRNA)Expand
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Multiple organ failure. Pathophysiology and potential future therapy.
  • E. Deitch
  • Medicine
  • Annals of surgery
  • 1 August 1992
Multiple organ failure (MOF) has reached epidemic proportions in most intensive care units and is fast becoming the most common cause of death in the surgical intensive care unit. Furthermore, inExpand
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Hypertrophic burn scars: analysis of variables.
A major problem in patients surviving thermal injury is the development of hypertrophic burn scars. The current study was performed to determine the factors associated with an increased risk of theExpand
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Role of the Gut in Multiple Organ Failure: Bacterial Translocation and Permeability Changes
Abstract. It is clear that increased gut permeability and bacterial translocation play a role in multiple organ failure (MOF). Failure of the gut barrier remains central to the hypothesis that toxinsExpand
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ANIMAL MODELS OF SEPSIS AND SHOCK: A REVIEW AND LESSONS LEARNED
Over the past decade, the biotechnology/pharmaceutical industry has been diligently working on the development of immunomodulatory agents for the treatment of shock and sepsis, and the literature isExpand
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Adenosine inhibits IL‐12 and TNF‐α production via adenosine A2a receptor‐dependent and independent mechanisms
Interleukin 12 (IL‐12) is a crucial cytokine in the regulation of T helper 1 vs. T helper 2 immune responses. In the present study, we investigated the effect of the endogenous purine nucleosideExpand
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American Burn Association Consensus Conference to Define Sepsis and Infection in Burns
Because of their extensive wounds, burn patients are chronically exposed to inflammatory mediators. Thus, burn patients, by definition, already have “systemic inflammatory response syndrome.” CurrentExpand
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Isolated traumatic brain injury: age is an independent predictor of mortality and early outcome.
BACKGROUND Geriatric trauma patients have a worse outcome than the young with comparable injuries. The contribution of traumatic brain injury (TBI) to this increased mortality is unknown and has beenExpand
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Gut lymph and lymphatics: a source of factors leading to organ injury and dysfunction
  • E. Deitch
  • Medicine
  • Annals of the New York Academy of Sciences
  • 1 October 2010
Major trauma, shock, sepsis, and other conditions can lead to the acute respiratory distress syndrome (ARDS), which may progress to the highly lethal multiple organ dysfunction syndrome (MODS).Expand
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Role of the gut in the development of injury- and shock induced SIRS and MODS: the gut-lymph hypothesis, a review.
It has long been recognized that major trauma, shock, or burn injury can lead to an acute systemic inflammatory state (SIRS) as well as the multiple organ dysfunction syndrome (MODS). Because of theExpand
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