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nikkomycin
Known as:
neopolyoxin C
, nikkomycin Z
National Institutes of Health
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Related topics
Related topics
3 relations
Broader (3)
Aminoglycosides
Antifungal Agents
Enzyme Inhibitors
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Modeling nikkomycin Z dosing and pharmacology in murine pulmonary coccidioidomycosis preparatory to phase 2 clinical trials.
L. Shubitz
,
H. Trinh
,
+4 authors
D. Nix
Journal of Infectious Diseases
2014
Corpus ID: 34492793
Nikkomycin Z (NikZ) is a chitin synthase inhibitor with activity against Coccidioides species that is being developed as a first…
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2010
2010
Cloning, reassembling and integration of the entire nikkomycin biosynthetic gene cluster into Streptomyces ansochromogenes lead to an improved nikkomycin production
G. Liao
,
Jine Li
,
Lei Li
,
Haihua Yang
,
Yuqing Tian
,
H. Tan
Microbial Cell Factories
2010
Corpus ID: 7215801
BackgroundNikkomycins are a group of peptidyl nucleoside antibiotics produced by Streptomyces ansochromogenes. They are…
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Highly Cited
2009
Highly Cited
2009
The pleiotropic regulator AdpA‐L directly controls the pathway‐specific activator of nikkomycin biosynthesis in Streptomyces ansochromogenes
Yuanyuan Pan
,
Gang Liu
,
Haihua Yang
,
Yuqing Tian
,
H. Tan
Molecular Microbiology
2009
Corpus ID: 19858027
The nikkomycin‐producing strain Streptomyces ansochromogenes has a homologue (adpA‐L) of the key pleiotropic Streptomyces…
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Highly Cited
2005
Highly Cited
2005
A pathway‐specific transcriptional regulatory gene for nikkomycin biosynthesis in Streptomyces ansochromogenes that also influences colony development
Gang Liu
,
Yuqing Tian
,
Haihua Yang
,
H. Tan
Molecular Microbiology
2005
Corpus ID: 46531339
DNA sequence analysis of a 7.5 kb XhoI DNA fragment from the region flanking the nikkomycin biosynthesis gene cluster in…
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2004
2004
Production of tylosin and nikkomycin by immobilized Streptomyces cells
M. Veelken
,
H. Pape
European Journal of Applied Microbiology and…
2004
Corpus ID: 41028517
SummaryMycelia of Streptomyces sp. T 59-235 and Streptomyces tendae Tü 901 (producing the antibiotics tylosin and nikkomycin…
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Highly Cited
2001
Highly Cited
2001
Synergy, Pharmacodynamics, and Time-Sequenced Ultrastructural Changes of the Interaction between Nikkomycin Z and the Echinocandin FK463 against Aspergillus fumigatus
C. Chiou
,
Nikolaos C Mavrogiorgos
,
Elizabeth Tillem
,
R. Hector
,
T. Walsh
Antimicrobial Agents and Chemotherapy
2001
Corpus ID: 5892459
ABSTRACT We investigated the potential synergy between two cell wall-active agents, the echinocandin FK463 (FK) and the chitin…
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1995
1995
Identification of cellular proteins involved in nikkomycin production in Steptomyces tendae Tü901
V. Möhrle
,
U. Roos
,
C. Bormann
Molecular Microbiology
1995
Corpus ID: 30966225
Expression of genes involved in nikkomycin production in Streptomyces tendae was investigated by two‐dimensional gel…
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Highly Cited
1994
Highly Cited
1994
Nikkomycin Z is a specific inhibitor of Saccharomyces cerevisiae chitin synthase isozyme Chs3 in vitro and in vivo
J. Gaughran
,
M. Lai
,
D. Kirsch
,
S. Silverman
Journal of Bacteriology
1994
Corpus ID: 36204121
Nikkomycin Z inhibits chitin synthase in vitro but does not exhibit antifungal activity against many pathogens. Assays of chitin…
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Highly Cited
1987
Highly Cited
1987
Formation of a new cell wall by protoplasts of Candida albicans: effect of papulacandin B, tunicamycin and Nikkomycin.
M. Elorza
,
A. Murgui
,
H. Rico
,
F. Miragall
,
R. Sentandreu
Journal of General Microbiology
1987
Corpus ID: 2094555
Incorporation of polysaccharides into the walls of regenerating protoplasts of Candida albicans was followed in the presence of…
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Highly Cited
1985
Highly Cited
1985
Mechanism of action of nikkomycin and the peptide transport system of Candida albicans.
P. McCarthy
,
P. Troke
,
K. Gull
Journal of General Microbiology
1985
Corpus ID: 2918710
Nikkomycin was found to be a potent growth inhibitor of Candida albicans through competitive inhibition of chitin synthase [Ki…
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