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nikkomycin

Known as: neopolyoxin C, nikkomycin Z 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (3)

AminoglycosidesAntifungal AgentsEnzyme Inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Modeling nikkomycin Z dosing and pharmacology in murine pulmonary coccidioidomycosis preparatory to phase 2 clinical trials.
Nikkomycin Z (NikZ) is a chitin synthase inhibitor with activity against Coccidioides species that is being developed as a first… 
2010
2010
Cloning, reassembling and integration of the entire nikkomycin biosynthetic gene cluster into Streptomyces ansochromogenes lead to an improved nikkomycin production
BackgroundNikkomycins are a group of peptidyl nucleoside antibiotics produced by Streptomyces ansochromogenes. They are… 
Highly Cited
2009
Highly Cited
2009
The pleiotropic regulator AdpA‐L directly controls the pathway‐specific activator of nikkomycin biosynthesis in Streptomyces ansochromogenes
The nikkomycin‐producing strain Streptomyces ansochromogenes has a homologue (adpA‐L) of the key pleiotropic Streptomyces… 
Highly Cited
2005
Highly Cited
2005
A pathway‐specific transcriptional regulatory gene for nikkomycin biosynthesis in Streptomyces ansochromogenes that also influences colony development
DNA sequence analysis of a 7.5 kb XhoI DNA fragment from the region flanking the nikkomycin biosynthesis gene cluster in… 
2004
2004
Production of tylosin and nikkomycin by immobilized Streptomyces cells
  • M. VeelkenH. Pape
  • European Journal of Applied Microbiology and…
  • 2004
  • Corpus ID: 41028517
SummaryMycelia of Streptomyces sp. T 59-235 and Streptomyces tendae Tü 901 (producing the antibiotics tylosin and nikkomycin… 
Highly Cited
2001
Highly Cited
2001
Synergy, Pharmacodynamics, and Time-Sequenced Ultrastructural Changes of the Interaction between Nikkomycin Z and the Echinocandin FK463 against Aspergillus fumigatus
ABSTRACT We investigated the potential synergy between two cell wall-active agents, the echinocandin FK463 (FK) and the chitin… 
1995
1995
Identification of cellular proteins involved in nikkomycin production in Steptomyces tendae Tü901
Expression of genes involved in nikkomycin production in Streptomyces tendae was investigated by two‐dimensional gel… 
Highly Cited
1994
Highly Cited
1994
Nikkomycin Z is a specific inhibitor of Saccharomyces cerevisiae chitin synthase isozyme Chs3 in vitro and in vivo
Nikkomycin Z inhibits chitin synthase in vitro but does not exhibit antifungal activity against many pathogens. Assays of chitin… 
Highly Cited
1987
Highly Cited
1987
Formation of a new cell wall by protoplasts of Candida albicans: effect of papulacandin B, tunicamycin and Nikkomycin.
Incorporation of polysaccharides into the walls of regenerating protoplasts of Candida albicans was followed in the presence of… 
Highly Cited
1985
Highly Cited
1985
Mechanism of action of nikkomycin and the peptide transport system of Candida albicans.
Nikkomycin was found to be a potent growth inhibitor of Candida albicans through competitive inhibition of chitin synthase [Ki… 
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