nikkomycin

Known as: neopolyoxin C, nikkomycin Z 
 
National Institutes of Health

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Broader (3)

AminoglycosidesAntifungal AgentsEnzyme Inhibitors

Papers overview

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2013
2013
Improvement of gougerotin and nikkomycin production by engineering their biosynthetic gene clusters
Nikkomycins and gougerotin are peptidyl nucleoside antibiotics with broad biological activities. The nikkomycin biosynthetic gene… (More)
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2010
2010
Cloning, reassembling and integration of the entire nikkomycin biosynthetic gene cluster into Streptomyces ansochromogenes lead to an improved nikkomycin production
BACKGROUND Nikkomycins are a group of peptidyl nucleoside antibiotics produced by Streptomyces ansochromogenes. They are… (More)
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2009
2009
The pleiotropic regulator AdpA-L directly controls the pathway-specific activator of nikkomycin biosynthesis in Streptomyces ansochromogenes.
The nikkomycin-producing strain Streptomyces ansochromogenes has a homologue (adpA-L) of the key pleiotropic Streptomyces… (More)
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Highly Cited
2005
Highly Cited
2005
A pathway-specific transcriptional regulatory gene for nikkomycin biosynthesis in Streptomyces ansochromogenes that also influences colony development.
DNA sequence analysis of a 7.5 kb XhoI DNA fragment from the region flanking the nikkomycin biosynthesis gene cluster in… (More)
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2002
2002
Formation of beta-hydroxy histidine in the biosynthesis of nikkomycin antibiotics.
Nikkomycins, a group of peptidyl nucleoside antibiotics produced Streptomyces tendae Tü901, are potent competitive inhibitors of… (More)
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2000
2000
Cloning and Function of sanQ: A Gene Involved in Nikkomycin Biosynthesis of Streptomyces ansochromogenes
A 2.8-kb BamHI fragment was cloned from the cosmid library of Streptomyces ansochromogenes by using the 1.35-kb BamHI-ApaI… (More)
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1998
1998
The Streptomyces tendae Tü901 L-lysine 2-aminotransferase catalyzes the initial reaction in nikkomycin D biosynthesis.
Protein P8 was previously identified as a putative nikkomycin biosynthesis protein. The gene (nikC) encoding protein P8 was… (More)
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Highly Cited
1994
Highly Cited
1994
Nikkomycin Z is a specific inhibitor of Saccharomyces cerevisiae chitin synthase isozyme Chs3 in vitro and in vivo.
Nikkomycin Z inhibits chitin synthase in vitro but does not exhibit antifungal activity against many pathogens. Assays of chitin… (More)
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1989
1989
Isolation of Streptomyces tendae mutants with an altered nikkomycin spectrum.
To isolate Streptomyces tendae mutants blocked in the biosynthesis of the nikkomycin nucleoside base 4-formyl-4-imidazoline-2-one… (More)
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1982
1982
Production of tylosin and nikkomycin by immobilized Streptomyces cells
Mycelia of Streptomyces sp. T 59-235 and Streptomyces tendae Tü 901 (producing the antibiotics tylosin and nikkomycin, resp… (More)
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