• Publications
  • Influence
NIM811, a Cyclophilin Inhibitor, Exhibits Potent In Vitro Activity against Hepatitis C Virus Alone or in Combination with Alpha Interferon
TLDR
Promising in vitro data warrant clinical investigation of NIM811, an inhibitor of novel mechanism, for the treatment of hepatitis C, since it binds to cyclophilins with higher affinity than cyclosporine but is devoid of the significant immunosuppressive activity associated with cyclospora.
Terbinafine: Mode of action and properties of the squalene epoxidase inhibition
  • N. Ryder
  • Biology
    The British journal of dermatology
  • 1 February 1992
TLDR
Measurement of ergosterol biosynthesis by incorporation of radiolabelled precursors indicates a correlation between inhibition of growth and ergosterl biosynthesis in a range of pathogenic fungi.
In Vitro Activities of Terbinafine against Cutaneous Isolates of Candida albicans and Other Pathogenic Yeasts
TLDR
Terbinafine was highly active against Candida parapsilosis and showed potentially interesting activity against isolates of Candida dubliniensis,Candida guilliermondii, Candida humicola, andCandida lusitaniae, while the clinical relevance of its activities against the other species has yet to be determined.
Clinical Trichophyton rubrum Strain Exhibiting Primary Resistance to Terbinafine
TLDR
The terbinafine-resistant isolates exhibited normal susceptibilities to clinically available antimycotics including itraconazole, fluconazoles, and griseofulvin, however, these isolates were fully cross resistant to several other known squalene epoxidase inhibitors, suggesting a target-specific mechanism of resistance.
Synergistic interaction of terbinafine with triazoles or amphotericin B against Aspergillus species.
TLDR
The results suggest potential clinical application of terbinafine in aspergillosis, either alone or in combination with amphotericin or triazoles, or with itraconazole or voriconazole.
Multiple amino acid substitutions in lanosterol 14alpha-demethylase contribute to azole resistance in Candida albicans.
TLDR
Multiple genetic alterations in C. albicans 14DM, including several not previously reported, can affect the affinity of the enzyme for azoles and contribute to resistance of clinical isolates.
Biological, Biochemical, and Molecular Characterization of a New Clinical Trichophyton rubrum Isolate Resistant to Terbinafine
TLDR
A new clinical strain of Trichophyton rubrum is characterized, highly resistant to terbinafine but exhibiting normal susceptibility to drugs with other mechanisms of action.
Amino Acid Substitution in Trichophyton rubrum Squalene Epoxidase Associated with Resistance to Terbinafine
TLDR
Terbinafine resistance in these T. rubrum clinical isolates appears to be due to a single amino acid substitution in SE, which is similar to that of yeast and mammalian SEs.
Role of the AcrAB-TolC Efflux Pump in Determining Susceptibility of Haemophilus influenzae to the Novel Peptide Deformylase Inhibitor LBM415
TLDR
Examination of acrR, encoding the putative repressor of pump gene expression, from several of these strains revealed mutations introducing frameshifts, stop codons, and amino acid changes relative to the published sequence, suggesting that loss of pump repression leads to decreased susceptibility.
...
...