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Molecular Regulation of Antibiotic Biosynthesis in Streptomyces
TLDR
The physiological signals and regulatory mechanisms may be of practical importance for the activation of the many cryptic secondary metabolic gene cluster pathways revealed by recent sequencing of numerous Streptomyces genomes. Expand
A complete sequence of the T. tengcongensis genome.
TLDR
It is concluded that thermophiles are a biologically and phylogenetically divergent group of prokaryotes that have converged to sustain extreme environmental conditions over evolutionary timescale. Expand
Autoregulation of antibiotic biosynthesis by binding of the end product to an atypical response regulator
TLDR
JadR1, an OmpR-type ARR of Streptomyces venezuelae, appears to activate the transcription of jadomycin B biosynthetic genes while repressing its own gene, and end-product-mediated control of antibiotic pathway-specific ARRs may be widespread. Expand
“Pseudo” γ-Butyrolactone Receptors Respond to Antibiotic Signals to Coordinate Antibiotic Biosynthesis*
TLDR
Pseudo GBL receptors play a novel role to coordinate antibiotic biosynthesis by binding and responding to antibiotics signals, suggesting an antibiotic-mediated regulatory mechanism could be a general strategy to coordinate antibiotics biosynthesis in the producing bacteria. Expand
Purification and biological characterization of halocin C8, a novel peptide antibiotic from Halobacterium strain AS7092
TLDR
Results indicate that halocin C8 is a novel microhalocin and its primary target might be located in the cell wall of the sensitive cells. Expand
Specialised metabolites regulating antibiotic biosynthesis in Streptomyces spp.
TLDR
Greater understanding of these autoregulatory and cross-regulatory activities may aid the discovery of new signalling molecules and their use in activating cryptic antibiotic biosynthetic pathways. Expand
A γ‐butyrolactone‐sensing activator/repressor, JadR3, controls a regulatory mini‐network for jadomycin biosynthesis
TLDR
The results revealed that the association of JadR3 and SVB1 plays an important role in controlling a regulatory mini‐network governing jadomycin biosynthesis, providing new insights into the ways in which γ‐butyrolactone/receptor systems modulate antibiotic biosynthesis in Streptomyces. Expand
Differential regulation of antibiotic biosynthesis by DraR‐K, a novel two‐component system in Streptomyces coelicolor
TLDR
The complexity of TCS in regulation of antibiotic biosynthesis in Streptomyces is revealed, showing higher avermectin while slightly decreased oligomycin A production, suggesting that DraR‐K‐mediated regulation system might be conserved in streptomycetes. Expand
Genome engineering and direct cloning of antibiotic gene clusters via phage ϕBT1 integrase-mediated site-specific recombination in Streptomyces
TLDR
A novel strategy based on phage ϕBT1 integrase-mediated site-specific recombination was developed, and used for simultaneous Streptomyces genome engineering and cloning of antibiotic gene clusters, which has been proved successful for the cloning of actinorhodin and daptomycin. Expand
A novel role of ‘pseudo’γ‐butyrolactone receptors in controlling γ‐butyrolactone biosynthesis in Streptomyces
TLDR
It is demonstrated that ScbR2, the pseudo GBL receptor in Streptomyces coelicolor, negatively controls the biosynthesis of γ‐butyrolactone (SCB1) by directly repressing the transcription of scbA, which encodes the key enzyme for SCB1 biosynthesis. Expand
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