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narbomycin

National Institutes of Health

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Macrolides

Papers overview

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2011
2011
Engineered biosynthesis of glycosylated derivatives of narbomycin and evaluation of their antibacterial activities
A 14-membered macrolide antibiotic narbomycin produced from Streptomyces venezuelae ATCC 15439 is composed of polyketide… 
Highly Cited
2009
Highly Cited
2009
Characterization and mechanistic studies of DesII: a radical S-adenosyl-L-methionine enzyme involved in the biosynthesis of TDP-D-desosamine.
D-desosamine (1) is a 3-(N,N-dimethylamino)-3,4,6-trideoxyhexose found in a number of macrolide antibiotics including methymycin… 
Highly Cited
2007
Highly Cited
2007
Engineering and analysis of a self-sufficient biosynthetic cytochrome P450 PikC fused to the RhFRED reductase domain.
Cytochrome P450 enzymes mediate important oxidative processes in biological systems including regio- and stereospecific… 
Highly Cited
2006
Highly Cited
2006
The Structural Basis for Substrate Anchoring, Active Site Selectivity, and Product Formation by P450 PikC from Streptomyces venezuelae*
The pikromycin (Pik)/methymycin biosynthetic pathway of Streptomyces venezuelae represents a valuable system for dissecting the… 
Highly Cited
2004
Highly Cited
2004
Characterization of the glycosyltransferase activity of desVII: analysis of and implications for the biosynthesis of macrolide antibiotics.
In vitro catalytic activity of DesVII, the glycosyltransferase involved in the biosynthesis of methymycin, neomethymycin… 
Highly Cited
2001
Highly Cited
2001
Characterization and Analysis of the PikD Regulatory Factor in the Pikromycin Biosynthetic Pathway ofStreptomyces venezuelae
ABSTRACT The Streptomyces venezuelae pikD gene from the pikromycin biosynthetic cluster was analyzed, and its deduced product… 
2000
2000
Genetic architecture of the polyketide synthases for methymycin and pikromycin series macrolides.
Review
1998
Review
1998
A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity.
In a survey of microbial systems capable of generating unusual metabolite structural variability, Streptomyces venezuelae ATCC… 
Highly Cited
1998
Highly Cited
1998
Characterization of the macrolide P-450 hydroxylase from Streptomyces venezuelae which converts narbomycin to picromycin.
The post-polyketide synthase (PKS) biosynthetic tailoring of macrolide antibiotics usually involves one or more oxidation… 
1998
1998
Macrolide biosynthesis: a single cytochrome P450, PicK, is responsible for the hydroxylations that generate methymycin, neomethymycin, and picromycin in Streptomyces venezuelae.
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