Actinohivin, a novel anti-HIV protein from an actinomycete that inhibits syncytium formation: isolation, characterization, and biological activities.
- H. Chiba, J. Inokoshi, S. Ōmura
- BiologyBiochemical and Biophysical Research…
- 30 March 2001
A novel anti-HIV protein that inhibits syncytium formation is discovered from a cultured broth of a soil isolate, actinomycete strain K97-0003, and consists of a 114-amino-acid chain that exhibits internal sequence triplication.
Inhibition of acyl-CoA: cholesterol acyltransferase activity by cyclodepsipeptide antibiotics.
The effect was studied of the fungal cyclodepsipeptide antibiotics beauvericin and seven distinct enniatins on acyl-CoA: cholesterol acyltransferase (ACAT) activity, indicating that the compound is one of the most potent ACAT inhibitors of microbial origin.
Kitasatosporia, a new genus of the order Actinomycetales.
- S. Ōmura, Y. Takahashi, Y. Iwai, H. Tanaka
- BiologyJournal of antibiotics (Tokyo. )
- 1 August 1982
The morphological, cultural, physiological and biochemical characteristics of a new actinomycete strain producing a new antibiotic, setamycin are described and the name Kitasatosporia is proposed, for which the type species is K. setalba.
Involvement of glucose catabolism in avermectin production by Streptomyces avermitilis
- H. Ikeda, H. Kotaki, H. Tanaka, S. Ōmura
- Biology, ChemistryAntimicrobial Agents and Chemotherapy
- 1 February 1988
The addition of glucose in the early stage of fermentation suppressed not only avermectin production but also the activity of 6-phosphogluconate dehydrogenase in the pentose phosphate pathway. On the…
A deacylation enzyme for aculeacin A, a neutral lipopeptide antibiotic, from Actinoplanes utahensis: purification and characterization.
- H. Takeshima, J. Inokoshi, Y. Takada, H. Tanaka, S. Omura
- Biology, ChemistryJournal of Biochemistry (Tokyo)
- 1 April 1989
An enzyme, tentatively termed aculeacin A acylase, useful in preparing deacylated peptides which are used as starting material for semisynthetic antifungal antibiotics, was purified from the culture…
Andrastins A-C, new protein farnesyltransferase inhibitors produced by Penicillium sp. FO-3929. I. Producing strain, fermentation, isolation, and biological activities.
- S. Ōmura, J. Inokoshi, S. Yamamura
- Biology, MedicineJournal of antibiotics (Tokyo. )
- 25 May 1996
New protein farnesyltransferase inhibitors, andrastins A-C, have been discovered in the cultured broth of Penicillium sp. FO-3929. Andrastins extracted from broth supernatant were purified by silica…
Correlation of antiangiogenic and antitumor efficacy of N-biphenyl sulfonyl-phenylalanine hydroxiamic acid (BPHA), an orally-active, selective matrix metalloproteinase inhibitor.
- R. Maekawa, H. Maki, T. Yoshioka
- Biology, ChemistryCancer Research
- 15 March 1999
Results indicate that selective MMP inhibition is correlated with antiangiogenic and antitumor efficacy and that the selective M MP inhibitor BPHA has therapeutic potential.
Transposon mutagenesis by Tn4560 and applications with avermectin-producing Streptomyces avermitilis
The Tn3-like Streptomyces transposon Tn4560 was used to mutagenize StrePTomyces avermitilis, the producer of anthelmintic avermectins and the cell growth inhibitor oligomycin, and was then used to construct an aver mectin production strain that no longer makes the toxic oligomcin.
Neuronal differentiation of neuro 2a cells by inhibitors of cell cycle progression, trichostatin A and butyrolactone I.
- J. Inokoshi, M. Katagiri, S. Ōmura
- Biology, ChemistryBiochemical and Biophysical Research…
- 16 March 1999
The findings suggest that the induction of the neuronal differentiation in Neuro 2a cells by these agents requires the cell cycle arrest at G1 phase, which is caused by inhibition of cycline dependent kinase, a target molecule of BLI and p21(WAF1).
Funalenone, a novel collagenase inhibitor produced by Aspergillus niger.
- J. Inokoshi, K. Shiomi, R. Masuma, H. Tanaka, H. Yamada, S. Ōmura
- Biology, ChemistryJournal of antibiotics (Tokyo. )
- 25 December 1999
Funalenone, a phenalene compound that inhibits type I collagenase (MMP-1), was isolated from mycelium of Aspergillus niger FO-5904 by solvent extaction, ODS column chromatography, Sephadex LH-20…