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Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis
The complete nucleotide sequence of the linear chromosome of Streptomyces avermitilis is determined and it is revealed that an internal 6.5-Mb region in the S. avermitILis genome was highly conserved with respect to gene order and content, and contained all known essential genes but showed perfectly asymmetric structure at the oriC center.
Genome sequence of an industrial microorganism Streptomyces avermitilis: Deducing the ability of producing secondary metabolites
Streptomyces avermitilis is a soil bacterium that carries out not only a complex morphological differentiation but also the production of secondary metabolites, one of which, avermectin, is
Genome Sequence of the Streptomycin-Producing Microorganism Streptomyces griseus IFO 13350
ABSTRACT We determined the complete genome sequence of Streptomyces griseus IFO 13350, a soil bacterium producing an antituberculosis agent, streptomycin, which is the first aminoglycoside
Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism
The suitability of the mutants as hosts for efficient production of foreign metabolites was shown by heterologous expression of three different exogenous biosynthetic gene clusters encoding the biosynthesis of streptomycin, cephamycin C, and pladienolide.
Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium that depends on microbial commensalism.
The genomic information from S.thermophilum offers new insights into microbial diversity and evolutionary sciences, and provides a framework for characterizing the molecular basis underlying microbial commensalism.
Genomic basis for natural product biosynthetic diversity in the actinomycetes.
Trends in the secondary metabolomes of natural product-rich actinomycetes are highlighted in this review article, which contains 199 references.
Terpene synthases are widely distributed in bacteria
A powerful search method based on the use of hidden Markov models (HMMs) and protein families database (Pfam) search that has allowed the discovery of monoterpene synthases of bacterial origin is described.
Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis.
Analysis of the gene cluster from Streptomyces avermitilis that governs the biosynthesis of the polyketide anthelmintic avermectin revealed that it contains four large ORFs encoding giant
Avenolide, a Streptomyces hormone controlling antibiotic production in Streptomyces avermitilis
A signaling molecule (avenolide) is purified from Streptomyces avermitilis and determined its structure, including stereochemistry, by spectroscopic analysis and chemical synthesis as (4S,10R)-10-hydroxy-10-methyl-9-oxo-dodec-2-en-1,4-olide, a class of Streptomeces autoregulator.
Avermectin Biosynthesis.