Genetic engineering of aminodeoxyhexose biosynthesis in Streptomyces fradiae

  title={Genetic engineering of aminodeoxyhexose biosynthesis in Streptomyces fradiae},
  author={Andrew R. Butler and Neil Bate and Douglas E. Kiehl and Herbert A. Kirst and Eric Cundliffe},
  journal={Nature Biotechnology},
The antibacterial properties of macrolide antibiotics (such as erythromycin, tylosin, and narbomycin) depend ultimately on the glycosylation of otherwise inactive polyketide lactones. Among the sugars commonly found in such macrolides are various 6-deoxyhexoses including the 3-dimethylamino sugars mycaminose and desosamine (4-deoxymycaminose). Some macrolides (such as tylosin) possess multiple sugar moieties, whereas others (such as narbomycin) have only single sugar substituents. As patterns… CONTINUE READING


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