• Publications
  • Influence
New directions for macrolide antibiotics: pharmacokinetics and clinical efficacy
  • H. Kirst, G. Sides
  • Biology, Medicine
  • Antimicrobial Agents and Chemotherapy
  • 1 September 1989
TLDR
Enhanced activity has been demonstrated in animal models and in vitro against toxoplasma, Legionella, Haemophilus, and Campylobacter spp, and new macrolide derivatives show promise to expand the antimicrobial spectrum of erythromycin to include Mycobacterium and Borrelia spp. Expand
Biological Activity of the Spinosyns, New Fermentation Derived Insect Control Agents, on Tobacco Budworm (Lepidoptera: Noctuidae) Larvae
TLDR
Spinosyn A demonstrates that natural products can provide efficacy against pest lepidopterous larvae, such as H.. virescens, that is on par with that observed for some of the most active synthetic insect control agents, including many pyrethroids. Expand
Historical Yearly Usage of Vancomycin
The reasons for the emergence and spread of vancomycin-resistant enterococci are not yet fully understood. Nevertheless, various hypotheses and proposals which are being vigorously and extensivelyExpand
The spinosyn family of insecticides: realizing the potential of natural products research
  • H. Kirst
  • Medicine, Biology
  • The Journal of Antibiotics
  • 12 February 2010
TLDR
The spinosyns have a unique mechanism of action (MOA) involving disruption of nicotinic acetylcholine receptors and generally show greater selectivity toward target insects and lesser activity against many beneficial predators as well as mammals and other aquatic and avian animals. Expand
Genetic and enzymatic basis of hygromycin B resistance in Escherichia coli
TLDR
A plasmid conferring resistance to the aminocyclitol antibiotic hygromycin B was isolated from Escherichia coli and the presence of the phosphotransferase in E. coli correlates with reduced accumulation of [14C]hygromyzin B. Expand
New directions for macrolide antibiotics: structural modifications and in vitro activity
  • H. Kirst, G. Sides
  • Biology, Medicine
  • Antimicrobial Agents and Chemotherapy
  • 1 September 1989
TLDR
During the past few years, several new derivatives of erythromycin have been identified during preclinical evaluation as sufficiently promising to warrant clinical investigations and are summarized in this minireview. Expand
The structure of A201A, a novel nucleoside antibiotic.
TLDR
The structure of the novel nucleoside antibiotic A201A has been determined by a combination of chemical and spectroscopic methods and has very interesting similarities and differences in structure with the known antibiotics puromycin and hygromycin A. Expand
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