The spinosyn family of insecticides: realizing the potential of natural products research
- H. Kirst
- BiologyJournal of antibiotics (Tokyo. )
- 12 February 2010
The spinosyns have a unique mechanism of action (MOA) involving disruption of nicotinic acetylcholine receptors and generally show greater selectivity toward target insects and lesser activity against many beneficial predators as well as mammals and other aquatic and avian animals.
New directions for macrolide antibiotics: pharmacokinetics and clinical efficacy
Enhanced activity has been demonstrated in animal models and in vitro against toxoplasma, Legionella, Haemophilus, and Campylobacter spp, and new macrolide derivatives show promise to expand the antimicrobial spectrum of erythromycin to include Mycobacterium and Borrelia spp.
Historical Yearly Usage of Vancomycin
- H. Kirst, D. Thompson, T. Nicas
- BiologyAntimicrobial Agents and Chemotherapy
- 1 May 1998
The reasons for the emergence and spread of vancomycin-resistant enterococci are not yet fully understood. Nevertheless, various hypotheses and proposals which are being vigorously and extensively…
Biological Activity of the Spinosyns, New Fermentation Derived Insect Control Agents, on Tobacco Budworm (Lepidoptera: Noctuidae) Larvae
- T. C. Sparks, G. Thompson, S. Thibault
- 1 December 1998
Spinosyn A demonstrates that natural products can provide efficacy against pest lepidopterous larvae, such as H.. virescens, that is on par with that observed for some of the most active synthetic insect control agents, including many pyrethroids.
Genetic and enzymatic basis of hygromycin B resistance in Escherichia coli
- R. Rao, N. Allen, J. N. Hobbs, W. Alborn, H. Kirst, J. W. Paschal
- Biology, ChemistryAntimicrobial Agents and Chemotherapy
- 1 November 1983
A plasmid conferring resistance to the aminocyclitol antibiotic hygromycin B was isolated from Escherichia coli and the presence of the phosphotransferase in E. coli correlates with reduced accumulation of [14C]hygromyzin B.
Fermentation-Derived Insect Control Agents
- T. C. Sparks, G. Thompson, T. Worden
Discovery, Isolation, and Structure Elucidation of a Family of Structurally Unique, Fermentation-Derived Tetracyclic Macrolides
- H. Kirst, K. Michel, G. Thompson
- 22 September 1992
New directions for macrolide antibiotics: structural modifications and in vitro activity
During the past few years, several new derivatives of erythromycin have been identified during preclinical evaluation as sufficiently promising to warrant clinical investigations and are summarized in this minireview.
Synthesis and antimicrobial evaluation of 20-deoxo-20-(3,5-dimethylpiperidin-1-yl)desmycosin (tilmicosin, EL-870) and related cyclic amino derivatives.
- M. Debono, K. Willard, E. E. Ose
- ChemistryJournal of antibiotics (Tokyo. )
- 25 August 1989
Several derivatives showed excellent oral efficacy against infections caused by P. multocida in chicks and one derivatives, 20-deoxo-20-(3,5-dimethylpiperidin-1-yl)desmycosin (tilmicosin or EL-870) was selected for development as a therapeutic agent for pasteurellosis in calves and pigs.