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metabotropic glutamate receptor 5

Known as: Receptor, Metabotropic Glutamate 5, mGluR5 Protein, Receptor 5, Metabotropic Glutamate 
Metabotropic glutamate receptor 5 (1212 aa, ~132 kDa) is encoded by the human GRM5 gene. This protein plays a role in both glutamate binding and… 
National Institutes of Health

Related topics

Related topics

19 relations
G Protein-Coupled Receptor GenesG Protein-Coupled Receptor SignalingGRM5 geneGRM5 wt Allele

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Metabotropic Glutamate Receptor 5a

Papers overview

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Highly Cited
2016
Highly Cited
2016
Metabotropic glutamate receptor 5 couples cellular prion protein to intracellular signalling in Alzheimer's disease.
Alzheimer's disease-related phenotypes in mice can be rescued by blockade of either cellular prion protein or metabotropic… 
Highly Cited
2011
Highly Cited
2011
Importance of Shank3 Protein in Regulating Metabotropic Glutamate Receptor 5 (mGluR5) Expression and Signaling at Synapses
Shank3/PROSAP2 gene mutations are associated with cognitive impairment ranging from mental retardation to autism. Shank3 is a… 
Highly Cited
2009
Highly Cited
2009
Norbin Is an Endogenous Regulator of Metabotropic Glutamate Receptor 5 Signaling
Norbin Knockout Metabotropic glutamate receptors (mGluRs) are critical neurotransmitter sensors implicated in central neuronal… 
Review
2008
Review
2008
Role for metabotropic glutamate receptor 5 (mGluR5) in the pathogenesis of fragile X syndrome
Metabotropic glutamate receptors (mGluRs) have been implicated in a diverse variety of neuronal functions. Studies reviewed here… 
Highly Cited
2005
Highly Cited
2005
The metabotropic glutamate receptor 5 antagonist MPEP decreased break points for nicotine, cocaine and food in rats
RationaleThe metabotropic glutamate (mGlu5) receptor subtype 5 antagonist MPEP attenuates self-administration of numerous drugs… 
Highly Cited
2002
Highly Cited
2002
Prostaglandin and Protein Kinase A-Dependent Modulation of Vanilloid Receptor Function by Metabotropic Glutamate Receptor 5: Potential Mechanism for Thermal Hyperalgesia
In addition to its role as a CNS neurotransmitter, glutamate has been shown recently to be an important component of the… 
Highly Cited
2000
Highly Cited
2000
Activation of Metabotropic Glutamate Receptor 5 Has Direct Excitatory Effects and Potentiates NMDA Receptor Currents in Neurons of the Subthalamic Nucleus
The subthalamic nucleus (STN) is a key nucleus in the basal ganglia motor circuit that provides the major glutamatergic… 
Highly Cited
2000
Highly Cited
2000
Anxiolytic-like effects of the prototypical metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine in rodents.
Recently, selective and systemically active antagonists for the metabotropic glutamate 5 receptor (mGlu(5)) were discovered, and… 
Highly Cited
1997
Highly Cited
1997
Mice Lacking Metabotropic Glutamate Receptor 5 Show Impaired Learning and Reduced CA1 Long-Term Potentiation (LTP) But Normal CA3 LTP
Class I metabotropic glutamate receptors (mGluRs) have been postulated to play a role in synaptic plasticity. To test the… 
Highly Cited
1994
Highly Cited
1994
Metabotropic glutamate receptor mRNA expression in the basal ganglia of the rat
Metabotropic glutamate receptors (mGluRs) couple the actions of glutamate to intracellular second messenger systems through G… 
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