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metabotropic glutamate receptor 5
Known as:
Receptor, Metabotropic Glutamate 5
, mGluR5 Protein
, Receptor 5, Metabotropic Glutamate
Â
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Metabotropic glutamate receptor 5 (1212 aa, ~132 kDa) is encoded by the human GRM5 gene. This protein plays a role in both glutamate binding and…Â
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Topic mentions per year
Topic mentions per year
1994-2018
0
20
40
60
1994
2018
Related topics
Related topics
19 relations
G Protein-Coupled Receptor Genes
G Protein-Coupled Receptor Signaling
GRM5 gene
GRM5 wt Allele
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Related mentions per year
Related mentions per year
1936-2018
1940
1960
1980
2000
2020
metabotropic glutamate receptor 5
Signal Transduction
physiological aspects
agonists
Synaptic Transmission
Receptors, Cell Surface
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain.
Andrew S. Doré
,
Krzysztof Okrasa
,
+10 authors
Fiona H Marshall
Nature
2014
Metabotropic glutamate receptors are class C G-protein-coupled receptors which respond to the neurotransmitter glutamate…Â
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Highly Cited
2013
Highly Cited
2013
Metabotropic Glutamate Receptor 5 Is a Coreceptor for Alzheimer Aβ Oligomer Bound to Cellular Prion Protein
Ji Won Um
,
Adam C. Kaufman
,
+10 authors
Stephen M Strittmatter
Neuron
2013
Soluble amyloid-β oligomers (Aβo) trigger Alzheimer's disease (AD) pathophysiology and bind with high affinity to cellular prion…Â
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Highly Cited
2011
Highly Cited
2011
Antibodies to metabotropic glutamate receptor 5 in the Ophelia syndrome.
Eric Lancaster
,
Elias Martinez-Hernandez
,
+12 authors
J. L. Dalmau
Neurology
2011
OBJECTIVE To report the metabotropic glutamate receptor 5 (mGluR5) as the autoantigen of antibodies from 2 patients with Hodgkin…Â
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Highly Cited
2009
Highly Cited
2009
Metabotropic glutamate receptor 5 (mGluR5) antagonists attenuate cocaine priming- and cue-induced reinstatement of cocaine seeking.
Vidhya Kumaresan
,
Menglu Yuan
,
+4 authors
R. Christopher Pierce
Behavioural brain research
2009
Accumulating evidence suggests that metabotropic glutamate receptors (mGluRs) are involved in both cocaine reinforcement and the…Â
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2007
2007
Homer 1a uncouples metabotropic glutamate receptor 5 from postsynaptic effectors.
Paul J. Kammermeier
,
Paul F Worley
Proceedings of the National Academy of Sciences…
2007
Metabotropic glutamate receptors (mGluRs) and Homer proteins play critical roles in neuronal functions including plasticity…Â
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Highly Cited
2005
Highly Cited
2005
The scaffold protein Homer1b/c links metabotropic glutamate receptor 5 to extracellular signal-regulated protein kinase cascades in neurons.
Limin Mao
,
Lu Yang
,
Qingsong Tang
,
Shazia Samdani
,
Guochi Zhang
,
John Q Wang
The Journal of neuroscience : the official…
2005
Group I metabotropic glutamate receptors (mGluRs) increase cellular levels of inositol-1,4,5-triphosphate (IP3) and thereby…Â
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Highly Cited
2001
Highly Cited
2001
Metabotropic glutamate receptors 1 and 5 differentially regulate CA1 pyramidal cell function.
Guido Mannaioni
,
Michael J Marino
,
Ornella Valenti
,
Stephen F Traynelis
,
P. Jeffery Conn
The Journal of neuroscience : the official…
2001
The activation of group I metabotropic glutamate receptors (mGluRs) produces a variety of actions that lead to alterations in…Â
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Highly Cited
2000
Highly Cited
2000
Activation of metabotropic glutamate receptor 5 has direct excitatory effects and potentiates NMDA receptor currents in neurons of the subthalamic nucleus.
Hanem M. Awad
,
Gilles Hubert
,
Yoav Smith
,
Andrew Levey
,
P. Jeffery Conn
The Journal of neuroscience : the official…
2000
The subthalamic nucleus (STN) is a key nucleus in the basal ganglia motor circuit that provides the major glutamatergic…Â
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Highly Cited
2000
Highly Cited
2000
Anxiolytic-like effects of the prototypical metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine in rodents.
Will Spooren
,
Annick Vassout
,
+5 authors
Conrad Gentsch
The Journal of pharmacology and experimental…
2000
Recently, selective and systemically active antagonists for the metabotropic glutamate 5 receptor (mGlu(5)) were discovered, and…Â
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Highly Cited
1997
Highly Cited
1997
Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP.
Y. M. Lu
,
Z.. Jia
,
+4 authors
John C. C. Roder
The Journal of neuroscience : the official…
1997
Class I metabotropic glutamate receptors (mGluRs) have been postulated to play a role in synaptic plasticity. To test the…Â
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