FAQ

metabotropic glutamate receptor 5

Known as: Receptor, Metabotropic Glutamate 5, mGluR5 Protein, Receptor 5, Metabotropic Glutamate 
Metabotropic glutamate receptor 5 (1212 aa, ~132 kDa) is encoded by the human GRM5 gene. This protein plays a role in both glutamate binding and… (More)

Topic mentions per year

Topic mentions per year

1994-2018
020406019942018

Related topics

Related topics

19 relations
G Protein-Coupled Receptor GenesG Protein-Coupled Receptor SignalingGRM5 geneGRM5 wt Allele
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Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
metabotropic glutamate receptor 5
Signal Transduction
physiological aspects
agonists
Synaptic Transmission
Receptors, Cell Surface

Papers overview

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Highly Cited
2014
Highly Cited
2014
Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain.
Metabotropic glutamate receptors are class C G-protein-coupled receptors which respond to the neurotransmitter glutamate… (More)
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Highly Cited
2013
Highly Cited
2013
Metabotropic Glutamate Receptor 5 Is a Coreceptor for Alzheimer Aβ Oligomer Bound to Cellular Prion Protein
Soluble amyloid-β oligomers (Aβo) trigger Alzheimer's disease (AD) pathophysiology and bind with high affinity to cellular prion… (More)
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Highly Cited
2011
Highly Cited
2011
Antibodies to metabotropic glutamate receptor 5 in the Ophelia syndrome.
OBJECTIVE To report the metabotropic glutamate receptor 5 (mGluR5) as the autoantigen of antibodies from 2 patients with Hodgkin… (More)
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Highly Cited
2009
Highly Cited
2009
Metabotropic glutamate receptor 5 (mGluR5) antagonists attenuate cocaine priming- and cue-induced reinstatement of cocaine seeking.
Accumulating evidence suggests that metabotropic glutamate receptors (mGluRs) are involved in both cocaine reinforcement and the… (More)
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2007
2007
Homer 1a uncouples metabotropic glutamate receptor 5 from postsynaptic effectors.
Metabotropic glutamate receptors (mGluRs) and Homer proteins play critical roles in neuronal functions including plasticity… (More)
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Highly Cited
2005
Highly Cited
2005
The scaffold protein Homer1b/c links metabotropic glutamate receptor 5 to extracellular signal-regulated protein kinase cascades in neurons.
Group I metabotropic glutamate receptors (mGluRs) increase cellular levels of inositol-1,4,5-triphosphate (IP3) and thereby… (More)
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Highly Cited
2001
Highly Cited
2001
Metabotropic glutamate receptors 1 and 5 differentially regulate CA1 pyramidal cell function.
The activation of group I metabotropic glutamate receptors (mGluRs) produces a variety of actions that lead to alterations in… (More)
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Highly Cited
2000
Highly Cited
2000
Activation of metabotropic glutamate receptor 5 has direct excitatory effects and potentiates NMDA receptor currents in neurons of the subthalamic nucleus.
The subthalamic nucleus (STN) is a key nucleus in the basal ganglia motor circuit that provides the major glutamatergic… (More)
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Highly Cited
2000
Highly Cited
2000
Anxiolytic-like effects of the prototypical metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine in rodents.
Recently, selective and systemically active antagonists for the metabotropic glutamate 5 receptor (mGlu(5)) were discovered, and… (More)
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Highly Cited
1997
Highly Cited
1997
Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP.
Class I metabotropic glutamate receptors (mGluRs) have been postulated to play a role in synaptic plasticity. To test the… (More)
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