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metabotropic glutamate receptor 5

Known as: Receptor, Metabotropic Glutamate 5, mGluR5 Protein, Receptor 5, Metabotropic Glutamate 
Metabotropic glutamate receptor 5 (1212 aa, ~132 kDa) is encoded by the human GRM5 gene. This protein plays a role in both glutamate binding and… Expand
National Institutes of Health

Related topics

Related topics

19 relations
G Protein-Coupled Receptor GenesG Protein-Coupled Receptor SignalingGRM5 geneGRM5 wt Allele
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Metabotropic Glutamate Receptor 5a

Papers overview

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Highly Cited
2014
Highly Cited
2014
Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain
Metabotropic glutamate receptors are class C G-protein-coupled receptors which respond to the neurotransmitter glutamate… Expand
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Highly Cited
2013
Highly Cited
2013
Metabotropic Glutamate Receptor 5 Is a Coreceptor for Alzheimer Aβ Oligomer Bound to Cellular Prion Protein
Soluble amyloid-β oligomers (Aβo) trigger Alzheimer's disease (AD) pathophysiology and bind with high affinity to cellular prion… Expand
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Highly Cited
2011
Highly Cited
2011
Antibodies to metabotropic glutamate receptor 5 in the Ophelia syndrome
Objective: To report the metabotropic glutamate receptor 5 (mGluR5) as the autoantigen of antibodies from 2 patients with Hodgkin… Expand
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Highly Cited
2009
Highly Cited
2009
Metabotropic glutamate receptor 5 (mGluR5) antagonists attenuate cocaine priming- and cue-induced reinstatement of cocaine seeking
Accumulating evidence suggests that metabotropic glutamate receptors (mGluRs) are involved in both cocaine reinforcement and the… Expand
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Highly Cited
2005
Highly Cited
2005
The Scaffold Protein Homer1b/c Links Metabotropic Glutamate Receptor 5 to Extracellular Signal-Regulated Protein Kinase Cascades in Neurons
Group I metabotropic glutamate receptors (mGluRs) increase cellular levels of inositol-1,4,5-triphosphate (IP3) and thereby… Expand
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Highly Cited
2001
Highly Cited
2001
Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons
Medium spiny neurons were recorded from striatal slices obtained from mice lacking the group I metabotropic glutamate receptor… Expand
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Highly Cited
2000
Highly Cited
2000
Activation of Metabotropic Glutamate Receptor 5 Has Direct Excitatory Effects and Potentiates NMDA Receptor Currents in Neurons of the Subthalamic Nucleus
The subthalamic nucleus (STN) is a key nucleus in the basal ganglia motor circuit that provides the major glutamatergic… Expand
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Highly Cited
1997
Highly Cited
1997
Mice Lacking Metabotropic Glutamate Receptor 5 Show Impaired Learning and Reduced CA1 Long-Term Potentiation (LTP) But Normal CA3 LTP
Class I metabotropic glutamate receptors (mGluRs) have been postulated to play a role in synaptic plasticity. To test the… Expand
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Highly Cited
1996
Highly Cited
1996
Metabotropic Glutamate Receptor 5 Is a Disulfide-linked Dimer*
The sequences of the metabotropic glutamate receptors (mGluRs) show little homology with other members of the G protein-coupled… Expand
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Highly Cited
1994
Highly Cited
1994
Metabotropic glutamate receptor mRNA expression in the basal ganglia of the rat
Metabotropic glutamate receptors (mGluRs) couple the actions of glutamate to intracellular second messenger systems through G… Expand
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