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GRM5 gene

Known as: MGLUR5, Glutamate Receptor, Metabotropic 5 Gene, GLUTAMATE RECEPTOR, METABOTROPIC, 5 
This gene is involved in G protein-coupled receptor signal transduction and phospholipase C signal transduction.
National Institutes of Health

Related topics

Related topics

7 relations
G Protein-Coupled Receptor SignalingLigand BindingReceptor SignalingSignal Transduction

Narrower (1)

GRM5 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
Alcohol Addiction- Metabotropic Glutamate Receptor Subtype 5 and its Ligands: How They All Come Together?
In the past decade, many studies have highlighted the role of metabotropic glutamate receptor subtype 5 (mGlu5) modulators in… 
Review
2016
Review
2016
Metabotropic glutamate receptor subtype 5: molecular pharmacology, allosteric modulation and stimulus bias
The metabotropic glutamate receptor subtype 5 (mGlu5) is a family C GPCR that has been implicated in various neuronal processes… 
2016
2016
Differential Adulthood Onset mGlu5 Signaling Saves Prefrontal Function in the Fragile X Mouse
Abstract The final maturation of the prefrontal cortex (PFC) continues into early adulthood and is delayed compared with other… 
2015
2015
Insights into the interaction of negative allosteric modulators with the metabotropic glutamate receptor 5: discovery and computational modeling of a new series of ligands with nanomolar affinity.
2011
2011
Discovery of molecular switches within the ADX-47273 mGlu5 PAM scaffold that modulate modes of pharmacology to afford potent mGlu5 NAMs, PAMs and partial antagonists.
2011
2011
Design and synthesis of substituted N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides as positive allosteric modulators of the metabotropic glutamate receptor subtype 5.
2008
2008
Metabolite Identification via LC‐SPE‐NMR‐MS of the In vitro Biooxidation Products of a Lead mGlu5 Allosteric Antagonist and Impact on the Improvement of Metabolic Stability in the Series
Detailed information on the metabolic fate of lead compounds can be a powerful tool for an informed approach to the stabilization… 
2008
2008
mGlu5 receptor deletion does not confer seizure protection to mice.
Highly Cited
2006
Highly Cited
2006
Comparison of the binding pockets of two chemically unrelated allosteric antagonists of the mGlu5 receptor and identification of crucial residues involved in the inverse agonism of MPEP
Fenobam [N‐(3‐chlorophenyl)‐N′‐(4,5‐dihydro‐1‐methyl‐4‐oxo‐1H‐imidazole‐2‐yl)urea], a clinically validated non‐benzodiazepine… 
Highly Cited
1999
Highly Cited
1999
A simple method to transfer plasmid DNA into neuronal primary cultures: functional expression of the mGlu5 receptor in cerebellar granule cells
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