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loracarbef

Known as: loracarbef [Chemical/Ingredient], (6R, 7S)-7-[(R)-2-Amino-2-phenylacetamido]-3-chloro-8-oxo-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid, Monohydrate, 1-Azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((aminophenylacetyl)amino)-3-chloro-8-oxo-, (6R-(6alpha,7beta(R*)))- 
A semi-synthetic, broad-spectrum, beta-lactamase resistant, second-generation cephalosporin antibiotic derived from cephasporium. The bactericidal… Expand
National Institutes of Health

Related topics

Related topics

19 relations

Broader (1)

Anti-Bacterial Agents
ArthropathyBacterial InfectionsBone Diseases, InfectiousCephalosporins
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Narrower (6)

CarbacLY 163892LorabidLorafem
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Papers overview

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Highly Cited
2000
Highly Cited
2000
Natural antibiotic susceptibility of Listeria species: L. grayi, L. innocua, L. ivanovii, L. monocytogenes, L. seeligeri and L. welshimeri strains.
OBJECTIVE To investigate the natural susceptibility to 71 antimicrobial agents of 103 Listeria strains belonging to all known… Expand
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Highly Cited
1999
Highly Cited
1999
Susceptibilities of Streptococcus pneumoniae and Haemophilus influenzae to 10 Oral Antimicrobial Agents Based on Pharmacodynamic Parameters: 1997 U.S. Surveillance Study
ABSTRACT The susceptibilities of Streptococcus pneumoniae (1,476 strains) and untypeable Haemophilus influenzae (1,676 strains… Expand
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Highly Cited
1997
Highly Cited
1997
Antibiotic resistance among clinical isolates of Haemophilus influenzae in the United States in 1994 and 1995 and detection of beta-lactamase-positive strains resistant to amoxicillin-clavulanate…
A total of 1,537 clinical isolates of Haemophilus influenzae were recovered in 30 U.S. medical center laboratories between 1… Expand
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Highly Cited
1996
Highly Cited
1996
Directed evolution of a para-nitrobenzyl esterase for aqueous-organic solvents
Through sequential generations of random mutagenesis and screening, we have directed the evolution of an esterase for… Expand
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Highly Cited
1996
Highly Cited
1996
Antimicrobial resistance of Streptococcus pneumoniae recovered from outpatients in the United States during the winter months of 1994 to 1995: results of a 30-center national surveillance study.
A total of 1,527 clinically significant outpatient isolates of Streptococcus pneumoniae were prospectively collected in 30… Expand
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Highly Cited
1995
Highly Cited
1995
Medical Management of Sinusitis: Educational Goals and Management Guidelines
  • D. Kennedy
  • The Annals of otology, rhinology & laryngology…
  • 1995
    • Corpus ID: 27623113
The primary goal of sinusitis management is resolution of infection, leading to patency of the ostiomeatal complex. Antibiotics… Expand
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Highly Cited
1994
Highly Cited
1994
Mechanism and Kinetics of Transcellular Transport of a New β-Lactam Antibiotic Loracarbef Across an Intestinal Epithelial Membrane Model System (Caco-2)
Various processes involved in the transcellular transport (TT) of loracarbef (LOR) were studied in the Caco-2 cell monolayer, a… Expand
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1994
1994
Transport mechanisms responsible for the absorption of loracarbef, cefixime, and cefuroxime axetil into human intestinal Caco-2 cells.
Loracarbef, cefixime and cefuroxime axetil are beta-lactam antibiotics that are administered orally. Oral absorption of… Expand
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Highly Cited
1993
Highly Cited
1993
Aqueous acidic degradation of the carbacephalosporin loracarbef.
The aqueous degradation of the carbacephalosporin loracarbef under moderately acidic conditions (pH range, 2.7-4.3) is described… Expand
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1991
1991
High-performance liquid chromatographic determination of loracarbef, a potential metabolite, cefaclor and cephalexin in human plasma, serum and urine.
A high-performance liquid chromatographic (HPLC) method is reported for the determination of a new carbacephem antibiotic… Expand
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