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- Publications
- Influence
Reversal of P-glycoprotein-mediated multidrug resistance by a potent cyclopropyldibenzosuberane modulator, LY335979.
- A. Dantzig, R. Shepard, +5 authors J. Starling
- Medicine, Biology
- Cancer research
- 15 September 1996
Overexpression of P-glycoprotein (Pgp) by tumors results in multidrug resistance (MDR) to structurally unrelated oncolytics. MDR cells may be sensitized to these oncolytics when treated with a Pgp… Expand
Selectivity of the multidrug resistance modulator, LY335979, for P-glycoprotein and effect on cytochrome P-450 activities.
- A. Dantzig, R. Shepard, +7 authors S. Wrighton
- Biology, Medicine
- The Journal of pharmacology and experimental…
- 1 August 1999
Overexpression of ATP-dependent drug efflux pumps, P-glycoprotein (Pgp) or multidrug resistance-associated protein (MRP), confers multidrug resistance to tumor cells. Modulators of multidrug… Expand
The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites
- S. Pratt, R. Shepard, R. Kandasamy, P. Johnston, W. Perry, A. Dantzig
- Medicine, Biology
- Molecular Cancer Therapeutics
- 1 May 2005
5′-Fluorouracil (5-FU), used in the treatment of colon and breast cancers, is converted intracellularly to 5′-fluoro-2′-deoxyuridine (5-FUdR) by thymidine phosphorylase and is subsequently… Expand
Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein.
- S. Ekins, R. Kim, +9 authors S. Wrighton
- Chemistry, Medicine
- Molecular pharmacology
- 1 May 2002
P-glycoprotein (P-gp) is an efflux transporter involved in limiting the oral bioavailability and tissue penetration of a variety of structurally divergent molecules. A better understanding of the… Expand
Uptake of the cephalosporin, cephalexin, by a dipeptide transport carrier in the human intestinal cell line, Caco-2.
- A. Dantzig, L. Bergin
- Chemistry, Medicine
- Biochimica et biophysica acta
- 7 September 1990
The transport of the orally absorbed cephalosporin, cephalexin, was examined in the human epithelial cell line, Caco-2 that possesses intestinal enterocyte-like properties when cultured. In… Expand
Application of three-dimensional quantitative structure-activity relationships of P-glycoprotein inhibitors and substrates.
- S. Ekins, R. Kim, +9 authors S. Wrighton
- Chemistry, Medicine
- Molecular pharmacology
- 1 May 2002
Using in vitro data, we previously built Catalyst 3-dimensional quantitative structure activity relationship (3D-QSAR) models that qualitatively rank and predict IC(50) values for P-glycoprotein… Expand
Modulation of P‐glycoprotein but not MRP1‐ or BCRP‐mediated drug resistance by LY335979
- R. Shepard, J. Cao, J. Starling, A. Dantzig
- Biology, Medicine
- International journal of cancer
- 2003
Our study examines the ability of LY335979 (Zosuquidar trihydrochloride) to modulate 3 distinct ABC transporters that are mechanisms of drug resistance: P‐glycoprotein (Pgp, ABCB1), multidrug… Expand
Considerations in the design and development of transport inhibitors as adjuncts to drug therapy.
- A. Dantzig, D. D. de Alwis, Michael Burgess
- Biology, Medicine
- Advanced drug delivery reviews
- 21 January 2003
With the realization of the importance of drug efflux transporters in disease processes and treatment, development of inhibitors to these transporters has been sought for use as adjuncts to therapy.… Expand
Mechanism and Kinetics of Transcellular Transport of a New β-Lactam Antibiotic Loracarbef Across an Intestinal Epithelial Membrane Model System (Caco-2)
- M. Hu, J. Chen, Yanping Zhu, A. Dantzig, Jr Robert E. Stratford, M. T. Kuhfeld
- Biology, Medicine
- Pharmaceutical Research
- 2004
Various processes involved in the transcellular transport (TT) of loracarbef (LOR) were studied in the Caco-2 cell monolayer, a cell culture model of the small intestinal epithelium. The results… Expand
Association of intestinal peptide transport with a protein related to the cadherin superfamily.
- A. Dantzig, J. A. Hoskins, +7 authors P. Rosteck
- Biology, Medicine
- Science
- 15 April 1994
The first step in oral absorption of many medically important peptide-based drugs is mediated by an intestinal proton-dependent peptide transporter. This transporter facilitates the oral absorption… Expand