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Practice guidelines for the management of bacterial meningitis.
TLDR
Allan R. Tunkel, Barry J. Hartman, Sheldon L. Kaplan, Bruce A. Kaufman, Karen L. Roos, W. Michael Scheld, and Richard J. Scheld are the authors of this study, which aims to contribute to the understanding of central nervous system disorders and its role in disease.
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Pathogenesis and pathophysiology of pneumococcal meningitis.
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The management of encephalitis: clinical practice guidelines by the Infectious Diseases Society of America.
TLDR
The guideline includes data on the epidemiology, clinical features, diagnosis, and treatment of many viral, bacterial, fungal, protozoal, and helminthic etiologies of encephalitis and provides information on when specific etiologic agents should be considered in individual patients with encephalopathy.
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The epidemic of antibiotic-resistant infections: a call to action for the medical community from the Infectious Diseases Society of America.
TLDR
If the antimicrobial resistance crisis is to be addressed, a concerted, grassroots effort led by the medical community will be required and could mean a literal return to the preantibiotic era for many types of infections.
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A Randomized Trial Comparing Fluconazole with Amphotericin B for the Treatment of Candidemia in Patients without Neutropenia
TLDR
A multicenter randomized trial that compared amphotericin B with fluconazole as treatment for candidemia, with the most common diagnoses being renal failure, nonhematologic cancer, and gastrointestinal disease.
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Infections of the central nervous system.
TLDR
The central nervous system syndromes mediated by bacterial toxins: botulism, J.J. Whitley and S. Stagno neurological manifestations of infection with the human immunodeficiency viruses, B.K. Plotkin Guillain-Barre syndrome and D.G. McLone.
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A randomized and blinded multicenter trial of high-dose fluconazole plus placebo versus fluconazole plus amphotericin B as therapy for candidemia and its consequences in nonneutropenic subjects.
TLDR
In nonneutropenic subjects, the combination of fluconazole plus AmB was not antagonistic compared with flu Conazole alone, and the combination trended toward improved success and more-rapid clearance from the bloodstream.
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Pathophysiology of bacterial meningitis: mechanism(s) of neuronal injury.
TLDR
The molecular mechanisms responsible for oxidant-induced neuronal injury in meningitis are explored and genetic targeting and/or pharmacologic blockade of the implicated pathways may be a future strategy for therapeutic adjunctive measures to improve outcome.
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Infectious etiologies of rhabdomyolysis: three case reports and review.
  • U. SinghW. Scheld
  • Medicine
    Clinical infectious diseases : an official…
  • 1 April 1996
TLDR
This study describes representative recent cases of rhabdomyolysis induced by influenza from an institution and details the wide variety of infections that can cause muscle damage.
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Bacterial meningitis: pathogenesis, pathophysiology, and progress.
TLDR
The mortality rate for adults who have Streptococcus pneumoniae meningitis remains 20 to 30 percent, with neurologic morbidity affecting half of survivors, and the incidence of persistent sensorineural hearing loss in children who survive bacterialmeningitis is 10 percent.
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