M. Pfaller

Publications905
h-index141
Citations85,672
Highly Influential Citations2,846
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Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem
TLDR
Improved non-culture-based diagnostics are needed to expand the potential for preemptive (or early directed) therapy and improve diagnostic, preventive, and therapeutic strategies is necessary to reduce the considerable morbidity and mortality associated with IC. Expand
Nosocomial bloodstream infections in United States hospitals: a three-year analysis.
TLDR
Concurrent surveillance for nosocomial bloodstream infections at 49 hospitals over a 3-year period detected >10,000 infections, and coagulase-negative staphylococci were the most common pathogens on all clinical services except obstetrics, where Escherichia coli was most common. Expand
Survey of infections due to Staphylococcus species: frequency of occurrence and antimicrobial susceptibility of isolates collected in the United States, Canada, Latin America, Europe, and the Western…
TLDR
Given the increasing multidrug resistance among staphylococci and the possible emergence of vancomycin-resistant strains, global strategies are needed to control emergence and spread of multiply resistant staphlyococci. Expand
Epidemiology of Invasive Mycoses in North America
TLDR
The epidemiologic profiles of these invasive mycoses in North America are discussed, as well as risk factors for infection, and the pathogens’ antifungal susceptibility. Expand
Attributable mortality of nosocomial candidemia, revisited.
TLDR
Nosocomial candidemia is still associated with an extremely high crude and attributable mortality--much higher than that expected from underlying disease alone. Expand
Results from the ARTEMIS DISK Global Antifungal Surveillance Study, 1997 to 2007: a 10.5-Year Analysis of Susceptibilities of Candida Species to Fluconazole and Voriconazole as Determined by CLSI…
TLDR
This survey identifies several less-common species of Candida with decreased susceptibility to azoles, which may pose a future threat to optimal antifungal therapy and underscore the importance of prompt and accurate species identification and antIFungal susceptibility testing. Expand
Antifungal drug resistance: mechanisms, epidemiology, and consequences for treatment.
  • M. Pfaller
  • Medicine
  • The American journal of medicine
  • 2012
TLDR
Standardized methods for reliable in vitro antifungal susceptibility testing are now available from the Clinical and Laboratory Standards Institute (CLSI) in the United States and the European Committee on Antimicrobial Susceptibility Testing (EUCAST) in Europe. Expand
Antifungal Susceptibilities of Candida Species Causing Vulvovaginitis and Epidemiology of Recurrent Cases
TLDR
The results support the use of azoles for empirical therapy of uncomplicated candidal vulvovaginitis and suggest recurrent episodes are more often caused by non-albicans species, for which azole agents are less likely to be effective. Expand
The epidemiology of candidemia in two United States cities: results of a population-based active surveillance.
TLDR
Detailed surveillance of Candida species isolated from blood in Atlanta and San Francisco during 1992-1993 document the substantial burden of candidemia and its changing epidemiology. Expand
Rare and Emerging Opportunistic Fungal Pathogens: Concern for Resistance beyond Candida albicans and Aspergillus fumigatus
The frequency of invasive mycoses due to opportunistic fungal pathogens has increased significantly over the past two decades (35, 74, 83, 88, 89, 101, 106). This increase in infections is associated… Expand
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