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lesopitron

Known as: 2-(4-(4-(4-chloro-1-pyrazolyl)butyl)-1-piperazinyl)pyrimidine, 2-(4-(4-(4-Chloropyrazol-1-yl)butyl)-1-piperazinyl)pyrimidine, Pyrimidine, 2-(4-(4-(4-chloro-1H-pyrazol-1-yl)butyl)-1-piperazinyl)-, dihydrochloride 
National Institutes of Health

Related topics

Related topics

3 relations

Narrower (1)

E 4424

Broader (2)

PiperazinesPyrimidines

Papers overview

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2004
2004
Effects of Lesopitron on the Central Nervous System Arising from Its Interaction with 5-HT1A Receptors
Lesopitron acts as a ligand for central serotonin 5-HT1A receptors. Ki obtained from [3H]8-OH-DPAT competition studies was 104.8… 
2000
2000
Efficacy and Safety of Lesopitron in Outpatients with Generalized Anxiety Disorder
OBJECTIVE: To compare the relative efficacy and safety of lesopitron 40–80 mg/d versus lorazepam 2–4 mg/d and placebo in a… 
1999
1999
Prevention by 5-HT1A receptor agonists of restraint stress- and yohimbine-induced release of cholecystokinin in the frontal cortex of the freely moving rat
1999
1999
The effects of the novel anxiolytic drug lesopitron, a full and selective 5-HT1A receptor agonist, on pupil diameter and oral temperature in man: comparison with buspirone
We investigated the effects of two 5-HT1A receptor agonists, buspirone and lesopitron, upon pupil size in human volunteers at an… 
1997
1997
Absorption, distribution and excretion of [14C]-Lesopitron after single and repeated administration in rats and dogs.
Disposition of [14C]-lesopitron was investigated in male rats and dogs after single and repeated oral administration… 
1996
1996
Preclinical profile of the mixed 5-HT1A/5-HT2A receptor antagonist S 21357
1996
1996
Electrophysiological effects of WAY 100635, a new 5-HT1A receptor antagonist, on dorsal raphe nucleus serotoninergic neurones and CA1 pyramidal cells in vitro.
The novel 5-HT1A receptor antagonist WAY 100635 [(N-(2-(-4(2-metoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyc lohexane… 
1994
1994
Effect of acute administration of the 5‐HT1A receptor ligand, lesopitron, on rat cortical 5‐HT and dopamine turnover
1 The involvement of presynaptic 5‐hydroxytryptamine1A (5‐HT1A) autoreceptors in the anxiolytic‐like properties of lesopitron (E… 
1994
1994
Interactions of lesopitron (E-4424) with central 5-HT1A receptors: in vitro and in vivo studies in the rat.
1993
1993
(−)Tertatolol is a potent antagonist at pre- and postsynaptic serotonin 5-HT1A receptors in the rat brain
SummaryThe potential 5-HT1A antagonist properties of the ß-antagonist tertatolol were assessed using biochemical and… 
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