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lesopitron

Known as: 2-(4-(4-(4-chloro-1-pyrazolyl)butyl)-1-piperazinyl)pyrimidine, 2-(4-(4-(4-Chloropyrazol-1-yl)butyl)-1-piperazinyl)pyrimidine, Pyrimidine, 2-(4-(4-(4-chloro-1H-pyrazol-1-yl)butyl)-1-piperazinyl)-, dihydrochloride 
 
National Institutes of Health

Papers overview

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2004
2004
Lesopitron acts as a ligand for central serotonin 5-HT1A receptors. Ki obtained from [3H]8-OH-DPAT competition studies was 104.8… Expand
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2000
2000
OBJECTIVE: To compare the relative efficacy and safety of lesopitron 40–80 mg/d versus lorazepam 2–4 mg/d and placebo in a… Expand
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1999
1999
We investigated the effects of two 5-HT1A receptor agonists, buspirone and lesopitron, upon pupil size in human volunteers at an… Expand
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1997
1997
Disposition of [14C]-lesopitron was investigated in male rats and dogs after single and repeated oral administration… Expand
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1996
1996
The modulation by K+ channel-acting drugs of the antinociceptive effect of several 5-HT1A receptor agonists was examined with the… Expand
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1996
1996
Lesopitron, a 5-hydroxytryptamine 1A agonist, is a new potential anxiolytic of the azapirone class. It has greater potency in… Expand
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1996
1996
We have studied the effects of the neuroleptic haloperidol and the non-benzodiazepine anxiolytics buspirone and lesopitron on the… Expand
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1994
1994
Previous studies have shown that the 5-HT1A receptor ligand, lesopitron (E-4424, 2-[4-[4-(4-chloro-1-pyrazolyl)butyl]-1… Expand
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1993
1993
SummaryThe potential 5-HT1A antagonist properties of the ß-antagonist tertatolol were assessed using biochemical and… Expand
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1993
1993
In vitro biochemical and electrophysiological methods were used to assess the potential antagonist properties of the novel… Expand
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