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lesopitron

Known as: 2-(4-(4-(4-chloro-1-pyrazolyl)butyl)-1-piperazinyl)pyrimidine, 2-(4-(4-(4-Chloropyrazol-1-yl)butyl)-1-piperazinyl)pyrimidine, Pyrimidine, 2-(4-(4-(4-chloro-1H-pyrazol-1-yl)butyl)-1-piperazinyl)-, dihydrochloride 
National Institutes of Health

Papers overview

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2000
2000
OBJECTIVE: To compare the relative efficacy and safety of lesopitron 40–80 mg/d versus lorazepam 2–4 mg/d and placebo in a… 
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1999
1999
We investigated the effects of two 5-HT1A receptor agonists, buspirone and lesopitron, upon pupil size in human volunteers at an… 
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1999
1999
In line with the idea that cholecystokinin (CCK) is involved in anxiety-related behaviours, previous investigations showed that… 
Highly Cited
1996
Highly Cited
1996
The aim of the present study was to examine the effects of N-(2-(4-2-methoxphenyl)-1-piperazinyl)ethyl)-N-(2-pyridnyl… 
1996
1996
Lesopitron, a 5-hydroxytryptamine 1A agonist, is a new potential anxiolytic of the azapirone class. It has greater potency in… 
1996
1996
The modulation by K+ channel-acting drugs of the antinociceptive effect of several 5-HT1A receptor agonists was examined with the… 
1996
1996
We have studied the effects of the neuroleptic haloperidol and the non-benzodiazepine anxiolytics buspirone and lesopitron on the… 
1994
1994
Previous studies have shown that the 5-HT1A receptor ligand, lesopitron (E-4424, 2-[4-[4-(4-chloro-1-pyrazolyl)butyl]-1… 
1994
1994
1 The involvement of presynaptic 5‐hydroxytryptamine1A (5‐HT1A) autoreceptors in the anxiolytic‐like properties of lesopitron (E… 
Highly Cited
1993
Highly Cited
1993
In vitro biochemical and electrophysiological methods were used to assess the potential antagonist properties of the novel…