• Publications
  • Influence
Epigenetic regulation of the BDNF gene: implications for psychiatric disorders
Abnormal brain-derived neurotrophic factor (BDNF) signaling seems to have a central role in the course and development of various neurological and psychiatric disorders. In addition, positive effectsExpand
  • 205
  • 18
Altered expression and functions of serotonin 5‐HT1A and 5‐HT1B receptors in knock‐out mice lacking the 5‐HT transporter
By taking up serotonin (5‐hydroxytryptamine, 5‐HT) released in the extracellular space, the 5‐HT transporter (5‐HTT) regulates central 5‐HT neurotransmission. Possible adaptive changes in 5‐HTExpand
  • 269
  • 16
VGLUT3 (Vesicular Glutamate Transporter Type 3) Contribution to the Regulation of Serotonergic Transmission and Anxiety
Three different subtypes of H+-dependent carriers (named VGLUT1–3) concentrate glutamate into synaptic vesicles before its exocytotic release. Neurons using other neurotransmitter than glutamateExpand
  • 129
  • 15
Attenuated hypoxic pulmonary hypertension in mice lacking the 5-hydroxytryptamine transporter gene.
Hypoxia is a well-recognized stimulus for pulmonary blood vessel remodeling and pulmonary hypertension development. One mechanism that may account for these effects is the direct action of hypoxia onExpand
  • 316
  • 13
Behavioural and neuroplastic effects of the new-generation antidepressant agomelatine compared to fluoxetine in glucocorticoid receptor-impaired mice.
Major depression is associated with reduced hippocampal volume linked to stress and high glucocorticoid secretion. Glucocorticoid receptor-impaired (GR-i) mice, a transgenic model for affectiveExpand
  • 112
  • 10
5-HT1 receptors.
  • L. Lanfumey, M. Hamon
  • Biology, Medicine
  • Current drug targets. CNS and neurological…
  • 31 January 2004
Among the seven classes of serotonin (5-hydroxytryptamine, 5-HT) receptors which have been identified to date, the 5-HT(1) class is comprised of five receptor types, with the 5-HT(1A), 5-HT(1B) andExpand
  • 141
  • 9
Antibodies and Antisense Oligonucleotide for Probing the Distribution and Putative Functions of Central 5-HT6Receptors
Among the recently cloned serotonin (5-hydroxytryptamine, 5-HT) receptors, the 5-HT6subtype is of special interest for at least two reasons: 1) it is abundant in limbic areas which participate in theExpand
  • 182
  • 8
Deficiency of the 5-Hydroxytryptamine Transporter Gene Leads to Cardiac Fibrosis and Valvulopathy in Mice
Background— Serotonin (5-hydroxytryptamine; 5-HT) overproduction is responsible for cardiac valvular disease in patients with carcinoid tumors. Reduced 5-HT inactivation is one proposed mechanism ofExpand
  • 117
  • 7
Excitatory amino acids in synaptic excitation of rat striatal neurones in vitro.
1. Intracellular recordings were made from rat striatal neurones in vitro. The cells had resting membrane potentials greater than -60 mV and action potentials greater than 70 mV with spike overshootExpand
  • 98
  • 7
RNA splicing and editing modulation of 5-HT2C receptor function: relevance to anxiety and aggression in VGV mice
Changes in serotonin2C receptor (5-HTR2c) editing, splicing and density were found in conditions such as depression and suicide, but mechanisms explaining the changes in 5-HTR2c function are unknown.Expand
  • 53
  • 7