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Novel naphthalenic ligands with high affinity for the melatonin receptor.
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Entrainment of circadian rhythms by S-20098, a melatonin agonist, is dose and plasma concentration dependent
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Melatonin analogues as agonists and antagonists in the circadian system and other brain areas.
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Agomelatine, the first melatonergic antidepressant: discovery, characterization and development
TLDR
Agomelatine (Valdoxan/Thymanax; Servier) was granted marketing authorization in 2009 for the treatment of major depression in Europe, thereby becoming the first approved antidepressant to incorporate a non-monoaminergic mechanism of action.
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Agomelatine: mechanism of action and pharmacological profile in relation to antidepressant properties
TLDR
The present review focuses on the pharmacological properties of this novel antidepressant, strikingly different from that of conventional classes of antidepressants, and opens perspectives towards a better understanding of the physiopathological bases underlying depression.
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Cloning and functional analysis of a polymorphic variant of the ovine Mel 1a melatonin receptor.
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Effects of SCN lesions on circadian blood pressure rhythm in normotensive and transgenic hypertensive rats.
TLDR
In nonlesioned TGR(mREN2)27 rats and Sprague-Dawley control rats, the melatonin antagonist S-22365 had no suppressive effect on LD-synchronized circadian rhythmicity, indicating that LD itself may have a stronger influence on the SCN than endogenous melatonin.
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Successful use of S20098 and melatonin in an animal model of delayed sleep-phase syndrome (DSPS)
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Effects of melatonin receptor ligands on swim test immobility
TLDR
Findings suggest that the melatonin receptor agonist S 20304 may have antidepressant potential.
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New methoxy-chroman derivatives, 4[N-(5-methoxy-chroman-3-yl)N- propylamino]butyl-8-azaspiro-(4,5)-decane-7,9-dione [(+/-)-S 20244] and its enantiomers, (+)-S 20499 and (-)-S 20500, with potent…
TLDR
In vitro, as well as in vivo, the inhibitory influence of the chroman derivatives on the discharge frequency of serotoninergic neurons could be competitively antagonized by (+/-)-tertatolol.
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