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Effects of lesions of the orbitofrontal cortex on sensitivity to delayed and probabilistic reinforcement
TLDR
Lesions of the OPFC can promote preference for the smaller and more immediate, and the larger and more certain of two reinforcers, and are consistent with two interpretations: the lesion may have altered the rates of delay and odds discounting, and/or sensitivity to the ratio of the sizes of the two rein forcers.
Disconnection as a mechanism for cognitive dysfunction in multiple sclerosis.
TLDR
T tract-based spatial statistics is applied to diffusion tensor imaging in a cohort of multiple sclerosis patients to identify loci where reduced white matter tract fractional anisotropy (FA) predicts impaired performance in cognitive testing, suggesting that TBSS reveals functionally relevant tract injury underlying cognitive dysfunction in patients with multiple sclerosis.
Theory and method in the quantitative analysis of ”impulsive choice” behaviour: implications for psychopharmacology
TLDR
The model gives rise to a quantitative methodology for studying impulsive choice, based on a family of linear indifference (null) equations, which describe performance under conditions of indifference, when the values of the reinforcers are assumed to be equal.
Effects of quinolinic acid-induced lesions of the orbital prefrontal cortex on inter-temporal choice: a quantitative analysis
TLDR
The results indicate that lesions of the OPFC can alter inter-temporal choice, either promoting or suppressing "impulsive choice", depending upon the relative sizes and delays of the two choice alternatives.
Effects of central 5-hydroxytryptamine depletion on sensitivity to delayed and probabilistic reinforcement
TLDR
These results provide additional evidence that central 5- HTergic mechanisms are involved in time discounting, but provide no evidence for a similar role of 5-HT in rats' sensitivity to probabilistic reinforcement.
The effect of d-amphetamine on performance on two operant timing schedules
TLDR
The results of experiment 2 support the notion that different neural mechanisms may be involved in timing tasks involving temporal distribution of responding and discrimination of the duration of exteroceptive stimuli and support the proposal that the drug reduces the period of the hypothetical pacemaker.
Does modafinil activate the locus coeruleus in man? Comparison of modafinil and clonidine on arousal and autonomic functions in human volunteers
TLDR
Clonidine exerted sympatholytic and sedative effects, whereas modafinil had sympathomimetic and some alerting effects, without affecting extracoerulear noradrenergic neurones involved in cardiovascular and salivary regulation.
Effect of central 5-hydroxytryptamine depletion on inter-temporal choice: a quantitative analysis
TLDR
Results indicate that central 5-HT depletion results in an increase in the rate of time discounting for food reinforcers, according to the multiplicative hyperbolic model.
Effects of quinolinic acid-induced lesions of the nucleus accumbens core on inter-temporal choice: a quantitative analysis
TLDR
The results confirm that lesions of the AcbC promote preference for smaller, earlier reinforcers and suggest that this reflects an effect of the lesion on the rate of delay discounting.
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