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leflunomide

Known as: alpha,alpha,alpha-Trifluoro-5-methyl-4-isoxazolecarboxy-P-toluidide, Lefunomide, N-(4-trifluoromethyphenyl)-5-methylisoxazole-4-carboxamide 
A derivative of isoxazole used for its immunosuppressive and anti-inflammatory properties. As a prodrug, leflunomide is converted to an active… 
National Institutes of Health

Related topics

Related topics

13 relations
Antirheumatic AgentsDrug AllergyLeflunomide:MCnc:Pt:Ser/Plas:QnPregnancy

Narrower (3)

AravaHWA 486SU101

Broader (3)

Enzyme InhibitorsImmunosuppressive AgentsIsoxazoles

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
ATP competitive inhibitors of D-alanine-D-alanine ligase based on protein kinase inhibitor scaffolds.
Review
2008
Review
2008
Use of Leflunomide in the Treatment of Polyomavirus BK-Associated Nephropathy
Objective: To review the available literature describing the use of leflunomide for the treatment of Polyomavirus BK-associated… 
Review
2006
Review
2006
Leflunomide in clinical practice.
Leflunomide (LEF) is a prodrug that is rapidly converted to its active metabolite A77 1726, that inhibits the novo pyrimidine… 
Review
2003
Review
2003
Low dose glucocorticoids in early rheumatoid arthritis.
The use of glucocorticoid therapy in the treatment of rheumatoid arthritis [RA] remains controversial. There has been much data… 
Highly Cited
2002
Highly Cited
2002
A novel leflunomide derivative, FK778, for immunosuppression after kidney transplantation in dogs.
BACKGROUND Leflunomide and its metabolite, A77 1726, interfere with pyrimidine metabolism and exert potent immunosuppression in… 
2001
2001
Early rheumatoid arthritis: a medical emergency?
Highly Cited
1997
Highly Cited
1997
Leflunomide and malononitriloamides.
Leflunomide is a new immunomodulatory drug effective in experimental models of autoimmune diseases and allo- or… 
1997
1997
Efficacy of immunosuppressive drugs in islet xenotransplantation: leflunomide in combination with cyclosporine and mycophenolate mofetil prevents islet xenograft rejection in the pig-to-rat model.
BACKGROUND Morphological characteristics of islet xenograft rejection differ from those of islet allograft rejection. Therefore… 
Highly Cited
1994
Highly Cited
1994
LEFLUNOMIDE CONTROLS REJECTION IN HAMSTER TO RAT CARDIAC XENOGRAFTS
Leflunomide is an isoxazole derivative that has the ability to prevent acute rejection of cardiac, renal, and skin transplants in… 
Highly Cited
1993
Highly Cited
1993
LEFLUNOMIDE, A NOVEL IMMUNOSUPPRESSIVE AGENT: THE MECHANISM OF INHIBITION OF T CELL PROLIFERATION
Leflunomide is a novel immunomodulating drug that has recently been demonstrated to prevent acute rejection and reverse ongoing… 
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