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leflunomide

Known as: alpha,alpha,alpha-Trifluoro-5-methyl-4-isoxazolecarboxy-P-toluidide, Lefunomide, N-(4-trifluoromethyphenyl)-5-methylisoxazole-4-carboxamide 
A derivative of isoxazole used for its immunosuppressive and anti-inflammatory properties. As a prodrug, leflunomide is converted to an active… 
National Institutes of Health

Related topics

Related topics

13 relations
Antirheumatic AgentsDrug AllergyLeflunomide:MCnc:Pt:Ser/Plas:QnPregnancy

Narrower (3)

AravaHWA 486SU101

Broader (3)

Enzyme InhibitorsImmunosuppressive AgentsIsoxazoles

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
ATP competitive inhibitors of D-alanine-D-alanine ligase based on protein kinase inhibitor scaffolds.
Highly Cited
2005
Highly Cited
2005
Leflunomide induced acute interstitial pneumonia.
We describe a 54-year-old woman with rheumatoid arthritis (RA), who developed acute respiratory failure 2 weeks after cessation… 
Highly Cited
2004
Highly Cited
2004
Modeling the 5-year cost effectiveness of treatment strategies including tumor necrosis factor-blocking agents and leflunomide for treating rheumatoid arthritis in the Netherlands.
OBJECTIVE To determine the cost effectiveness of treatment strategies for rheumatoid arthritis patients satisfying the indication… 
Review
2004
Review
2004
Effects of leflunomide on immune responses and models of inflammation
ConclusionsLeflunomide is an antiphlogistic and immunomodulating agent that has been shown to be effective in preventing and… 
Highly Cited
2002
Highly Cited
2002
A novel leflunomide derivative, FK778, for immunosuppression after kidney transplantation in dogs.
BACKGROUND Leflunomide and its metabolite, A77 1726, interfere with pyrimidine metabolism and exert potent immunosuppression in… 
Highly Cited
1997
Highly Cited
1997
Leflunomide and malononitriloamides.
Leflunomide is a new immunomodulatory drug effective in experimental models of autoimmune diseases and allo- or… 
Highly Cited
1995
Highly Cited
1995
Leflunomide interferes with pyrimidine nucleotide biosynthesis
Leflunomide is an anti-inflammatory and immunosuppressive agent which blocks proliferation of transformed cells and mitogen… 
Highly Cited
1995
Highly Cited
1995
DIFFERENTIAL EFFECTS OF THE IMMUNOSUPPRESSIVE AGENTS CYCLOSPORINE AND LEFLUNOMIDE IN VIVO LEFLUNOMIDE BLOCKS CLONAL T CELL EXPANSION YET ALLOWS PRODUCTION OF LYMPHOKINES AND MANIFESTATION OF T CELL…
The effects of leflunomide and CsA on immune responses in vitro and in vivo were investigated. Like CsA, leflunomide inhibited… 
Highly Cited
1994
Highly Cited
1994
LEFLUNOMIDE CONTROLS REJECTION IN HAMSTER TO RAT CARDIAC XENOGRAFTS
Leflunomide is an isoxazole derivative that has the ability to prevent acute rejection of cardiac, renal, and skin transplants in… 
Highly Cited
1993
Highly Cited
1993
LEFLUNOMIDE, A NOVEL IMMUNOSUPPRESSIVE AGENT: THE MECHANISM OF INHIBITION OF T CELL PROLIFERATION
Leflunomide is a novel immunomodulating drug that has recently been demonstrated to prevent acute rejection and reverse ongoing… 
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