leflunomide

Known as: alpha,alpha,alpha-Trifluoro-5-methyl-4-isoxazolecarboxy-P-toluidide, Lefunomide, N-(4-trifluoromethyphenyl)-5-methylisoxazole-4-carboxamide 
A derivative of isoxazole used for its immunosuppressive and anti-inflammatory properties. As a prodrug, leflunomide is converted to an active… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1949-2018
05010019492017

Papers overview

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Review
2016
Review
2016
The crucial issue for a better pregnancy outcome in women with autoimmune rheumatic diseases is appropriate planning, with… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND Polyoma BK virus produces an aggressively destructive nephropathy in approximately 3% to 8% of renal allografts, is… (More)
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2005
2005
BACKGROUND We compared the safety and efficacy of leflunomide with that of methotrexate in the treatment of polyarticular… (More)
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2004
2004
OBJECTIVE To investigate the safety and efficacy of leflunomide plus low-dose prednisolone for the maintenance of remission in… (More)
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Highly Cited
2002
Highly Cited
2002
OBJECTIVE To explore the feasibility of prospectively monitoring treatment efficacy and tolerability of infliximab, etanercept… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND Disease-modifying antirheumatic drugs may confer greater benefits when combined with the antimetabolite methotrexate… (More)
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Highly Cited
2000
Highly Cited
2000
OBJECTIVE To compare the clinical efficacy and safety of leflunomide and methotrexate for the treatment of rheumatoid arthritis… (More)
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Highly Cited
1999
Highly Cited
1999
CONTEXT Leflunomide is a reversible inhibitor of de novo pyrimidine synthesis shown to be effective in a phase 2 trial in 402… (More)
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Highly Cited
1999
Highly Cited
1999
BACKGROUND Phase II trials of leflunomide, an inhibitor of de-novo pyrimidine synthesis, have shown efficacy in rheumatoid… (More)
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Highly Cited
1995
Highly Cited
1995
Leflunomide is a novel immunosuppressive compound that is effective in the treatment of animal models of autoimmune disease and… (More)
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