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Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.
A panel of antigen-specific mouse helper T cell clones was characterized according to patterns of lymphokine activity production, and two types of T cell were distinguished. Type 1 T helper cells
Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal
Lymphokine synthesis patterns of a panel of 19 T cell clones have been evaluated, using mRNA hybridization methods to examine 11 different mRNAs induced by Con A, and it is shown that secreted protein and mRNA levels correlated well for all cell lines.
Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1
The ability of Raf to elicit cell cycle arrest is strongly associated with its ability to induce the expression of the cyclin-dependent kinase inhibitor p21Cip1 in a manner that bears analogy to alpha-factor arrest in Saccharomyces cerevisiae.
Characterization of the CD200 Receptor Family in Mice and Humans and Their Interactions with CD200 1
The first characterization of human CD200R (hCD200R) is reported and its binding characteristics to hCD200 are defined, and two mCD200 receptor-like family members were shown to pair with the activatory adaptor protein, DAP12, suggesting that these receptors would transmit strong activating signals in contrast to the apparent inhibitory signal delivered by triggering the CD 200R.
Molecular Mechanisms of CD200 Inhibition of Mast Cell Activation
A novel inhibitory pathway used by CD200R in modulating mast cell function is defined and help to explain how engagement of this receptor in vivo regulates myeloid cell function.
Dap10 and Dap12 Form Distinct, but Functionally Cooperative, Receptor Complexes in Natural Killer Cells
Although cross-linking of either DAP10- or DAP12-associated receptors has been shown to be sufficient to trigger NK cell–mediated cytotoxicity against Fc receptor–bearing cells, substantial synergy was observed in the induction of cytokine production when both receptors were engaged.
Regulation of Myeloid Cell Function through the CD200 Receptor1
Direct evidence is provided that the CD200-CD200R interaction controls monocyte/macrophage function in both murine and human systems, further supporting the potential clinical application of CD200R agonists for the treatment of chronic inflammatory diseases.
The Role of Helper T Cell Products in Mouse B Cell Differentiation and Isotype Regulation
This review summarizes efforts to define the specific TH products or lymphokines which transmit regulatory signals to B cells, and to clarify the individual events influenced by these signals.
The immunosuppressant leflunomide inhibits lymphocyte proliferation by inhibiting pyrimidine biosynthesis.
The results support the hypothesis that the in vitro effects of leflunomide on T-lymphocytes are due to inhibition of de novo pyrimidine synthesis, and inhibition of dihydroorotate dehydrogenase.
Rapid phosphorylation of Ets-2 accompanies mitogen-activated protein kinase activation and the induction of heparin-binding epidermal growth factor gene expression by oncogenic Raf-1
Ets-2 is firmly established as a direct target of the Raf-MEK-MAP kinase signaling pathway and strongly implicate Ets- 2 in the regulation of HB-EGF gene expression.