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laudanosine

National Institutes of Health

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Central Nervous System AgentsIsoquinolines

Papers overview

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2010
2010
Determination of atracurium, cisatracurium and mivacurium with their impurities in pharmaceutical preparations by liquid chromatography with charged aerosol detection.
2004
2004
The GC-MS detection and characterization of reticuline as a marker of opium use.
2002
2002
Cerebrospinal fluid concentrations of atracurium, laudanosine and vecuronium following clinical subarachnoid hemorrhage
Background: Neuromuscular blocking agents may exert central nervous system effects when they reach the brain. This study assessed… 
2002
2002
Methyl-laudanosine: a new pharmacological tool to investigate the function of small-conductance Ca(2+)-activated K(+) channels.
Small-conductance Ca(2+)-activated K(+) channels (SK channels) underlie the prolonged postspike afterhyperpolarization (AHP… 
2001
2001
Blockade and Activation of the Human Neuronal Nicotinic Acetylcholine Receptors by Atracurium and Laudanosine
BackgroundCuraremimetic nondepolarizing muscle relaxants are widely used in clinical practice to prevent muscle contraction… 
1995
1995
Simultaneous determination of dextrorphan and guaifenesin in human plasma by liquid chromatography with fluorescence detection.
1988
1988
Separation of eight alkaloids and meconic acid and quantitation of five principal alkaloids in gum opium by gradient reversed-phase high-performance liquid chromatography.
1986
1986
Pharmacology of Laudanosine in Dogs
The authors determined the pharmacokinetics (including transfer ito cerebrospinal fluid [CSF]) and the cardiovascular and central… 
1986
1986
Convulsive effects and pharmacokinetics of laudanosine in the rat.
Laudanosine, which is a degradation product of atracurium, is a convulsant drug in the rat. Laudanosine plasma concentrations… 
1985
1985
Laudanosine (A Metabolite of Atracurium) Increases the Minimum Alveolar Concentration of Halothane in Rabbits
The authors hypothesized that laudanosine, a metabolite of atracurium and a central nervous system stimulant, might increase the… 
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