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The KCNQ Channel Opener Retigabine Inhibits the Activity of Mesencephalic Dopaminergic Systems of the Rat
TLDR
Observations indicate that retigabine negatively modulates dopaminergic neurotransmission, likely originating from stimulation of mesencephalic KCNQ4 channels. Expand
Cognitive impairment, dementia and quality of life in patients and caregivers.
TLDR
It is suggested that improving the cognitive status of patients and providing assistance to caregivers would be complementary ways of action to support caregiving of patients living at home. Expand
A new approach to the qualitative evaluation of functional disability in dementia
TLDR
In order to differentiate between mild, moderate and severe patients both instrumental and basic functional disabilities should be taken into account simultaneously. Expand
Modulation of small conductance calcium-activated potassium (SK) channels: a new challenge in medicinal chemistry.
TLDR
Small conductance calcium-activated potassium (SK) channels are found in many types of neurons as well as in some other cell types, and are heavily expressed in the basal ganglia and in the limbic system, suggesting that they may modulate motricity and emotional behaviour. Expand
Hydrogen peroxide hyperpolarizes rat CA1 pyramidal neurons by inducing an increase in potassium conductance
TLDR
It is suggested that hydrogen peroxide is able to induce an increase in potassium conductance in rat CA1 pyramidal neurons through hyperpolarization, and the exact mechanism by which it produces this effect remains to be determined. Expand
The economic impact of dementia in Belgium: results of the National Dementia Economic Study (NADES).
TLDR
A large fraction of the costs observed in dementia is explained by the association of dementia with physical dependence, co-morbidity and need for caregiving, and the results support the caring for patients at home. Expand
SK channels control the firing pattern of midbrain dopaminergic neurons in vivo
TLDR
The first demonstration of a major role of SK channels in the control of the switch between tonic and burst firing of dopaminergic neurons in physiological conditions is provided, which suggests a new strategy to develop modulators of the dopamine (DA) system. Expand
Evidence for a non-GABAergic action of quaternary salts of bicuculline on dopaminergic neurones
TLDR
The results strongly suggest that quaternary salts of bicuculline act on more than one target in the central nervous system, and the involvement of GABA(A) receptors in a given effect cannot be proven solely on the basis of its blockade by these agents. Expand
Electrophysiological characterization of the SK channel blockers methyl‐laudanosine and methyl‐noscapine in cell lines and rat brain slices
TLDR
Both methyl‐laudanosine and methyl‐noscapine are medium potency, quickly dissociating, SK channel blockers with a similar potency on the three SK subtypes and may be superior in terms of specificity for the SK channels. Expand
Spontaneous apamin-sensitive hyperpolarizations in dopaminergic neurons of neonatal rats.
TLDR
It is concluded that dopaminergic neurons have developmentally regulated physiological properties and spontaneous hyperpolarizations might affect the firing rate of these cells, which was found to be lower in neonates than in adults. Expand
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