Laudanosine (A Metabolite of Atracurium) Increases the Minimum Alveolar Concentration of Halothane in Rabbits

@article{Shi1985LaudanosineM,
  title={Laudanosine (A Metabolite of Atracurium) Increases the Minimum Alveolar Concentration of Halothane in Rabbits},
  author={W. Shi and M. Fahey and D. Fisher and R. Miller and C. Canfell and E. Eger},
  journal={Anesthesiology},
  year={1985},
  volume={63},
  pages={584–588}
}
  • W. Shi, M. Fahey, +3 authors E. Eger
  • Published 1985
  • Medicine
  • Anesthesiology
  • The authors hypothesized that laudanosine, a metabolite of atracurium and a central nervous system stimulant, might increase the minimum alveolar concentration (MAC) of halothane. An initial study in five rabbits anesthetized with halothane used a two-compartment model to produce estimates of pharmacokinetic variables for laudanosine. These estimates were used to determine the rates of infusion that would produce steady state plasma concentrations of laudanosine of approximately 200, 400, and… CONTINUE READING
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