Central Nervous System Agents

Known as: centrally acting drugs, central medication nervous system, central medications nervous system 
A class of drugs producing both physiological and psychological effects through a variety of mechanisms. They can be divided into "specific" agents… (More)
National Institutes of Health

Related topics

Related topics

19 relations

Narrower (10)

Antidepressive AgentsAntitussive AgentsCentral Nervous System DepressantsCentral Nervous System Stimulants
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Illicit DrugsIn Bloodagonistsantagonists & inhibitors
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Broader (2)

Pharmaceutical Preparationsneuropharmacologic agent

Papers overview

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2012
2012
Knowledge-Based, Central Nervous System (CNS) Lead Selection and Lead Optimization for CNS Drug Discovery
The central nervous system (CNS) is the major area that is affected by aging. Alzheimer's disease (AD), Parkinson's disease (PD… (More)
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Review
2006
Review
2006
Drosophila melanogaster neurobiology, neuropharmacology, and how the fly can inform central nervous system drug discovery.
Central nervous system (CNS) drug discovery in the post-genomic era is rapidly evolving. Older empirical methods are giving way… (More)
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Review
2006
Review
2006
Functional abdominal pain syndrome.
Functional abdominal pain syndrome (FAPS) differs from the other functional bowel disorders; it is less common, symptoms largely… (More)
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Review
2005
Review
2005
The blood-brain barrier: Bottleneck in brain drug development
The blood-brain barrier (BBB) is formed by the brain capillary endothelium and excludes from the brain ∼100% of large-molecule… (More)
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Highly Cited
2003
Highly Cited
2003
Smoking, alcoholism and genetic polymorphisms alter CYP2B6 levels in human brain
CYP2B6 metabolizes drugs such as nicotine and bupropion, and many toxins and carcinogens. Nicotine induces CYP2B1 in rat brain… (More)
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Review
2002
Review
2002
Regulators of G-Protein signalling as new central nervous system drug targets
G-protein-coupled receptors (GPCRs) are major targets for drug discovery. The regulator of G-protein signalling (RGS)-protein… (More)
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Review
2001
Review
2001
In vivo fatty acid incorporation into brain phosholipids in relation to plasma availability, signal transduction and membrane remodeling
A method, model, and “operational equations” are described to quantify in vivo turnover rates and half-lives of fatty acids… (More)
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Highly Cited
1992
Highly Cited
1992
Drug transfer across the blood-brain barrier: Correlation between “in vitro” and “in vivo” models
To assess the drug transport across the blood-brain barrier (BBB), we compared the maximal brain extraction values at time 0 [E(0… (More)
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Highly Cited
1989
Highly Cited
1989
Modified formalin test: characteristic biphasic pain response
A modified formalin test in mice was investigated. The pain response curve induced by 0.5% formalin was biphasic, having 2 peaks… (More)
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Highly Cited
1984
Highly Cited
1984
Trans-striatal dialysis coupled to reverse phase high performance liquid chromatography with electrochemical detection: a new method for the study of the in vivo release of endogenous dopamine and…
A method for the estimation in rats of the in vivo release and metabolism of dopamine (DA) is described. The method is based on… (More)
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