Central Nervous System Agents

Known as: centrally acting drugs, central medication nervous system, central medications nervous system 
A class of drugs producing both physiological and psychological effects through a variety of mechanisms. They can be divided into "specific" agents… (More)
National Institutes of Health

Papers overview

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2012
2012
The central nervous system (CNS) is the major area that is affected by aging. Alzheimer's disease (AD), Parkinson's disease (PD… (More)
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Review
2006
Review
2006
Central nervous system (CNS) drug discovery in the post-genomic era is rapidly evolving. Older empirical methods are giving way… (More)
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Review
2006
Review
2006
Functional abdominal pain syndrome (FAPS) differs from the other functional bowel disorders; it is less common, symptoms largely… (More)
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Review
2005
Review
2005
The blood-brain barrier (BBB) is formed by the brain capillary endothelium and excludes from the brain ∼100% of large-molecule… (More)
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Highly Cited
2003
Highly Cited
2003
CYP2B6 metabolizes drugs such as nicotine and bupropion, and many toxins and carcinogens. Nicotine induces CYP2B1 in rat brain… (More)
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Review
2002
Review
2002
G-protein-coupled receptors (GPCRs) are major targets for drug discovery. The regulator of G-protein signalling (RGS)-protein… (More)
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Review
2001
Review
2001
A method, model, and “operational equations” are described to quantify in vivo turnover rates and half-lives of fatty acids… (More)
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Highly Cited
1992
Highly Cited
1992
To assess the drug transport across the blood-brain barrier (BBB), we compared the maximal brain extraction values at time 0 [E(0… (More)
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Highly Cited
1989
Highly Cited
1989
A modified formalin test in mice was investigated. The pain response curve induced by 0.5% formalin was biphasic, having 2 peaks… (More)
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Highly Cited
1984
Highly Cited
1984
A method for the estimation in rats of the in vivo release and metabolism of dopamine (DA) is described. The method is based on… (More)
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