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Molecular heterogeneity of benzodiazepine receptors
Benzodiazepines exhibit reversible, stereospecific high affinity binding to mammalian brain membranes, and the respective binding sites for 3H-flunitrazepam represent pharmacologically and clinicallyExpand
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Stimulation of benzodiazepine receptor binding by gamma-aminobutyric acid.
  • M. Karobath, G. Sperk
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 February 1979
The effect of the neurotransmitter gamma-aminobutyric acid (GABA) on high-affinity binding of benzodiazepines to brain membranes has been investigated. GABA stimulated [3H]diazepam binding by moreExpand
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Dopamine D2 receptors in the rat brain: autoradiographic visualization using a high-affinity selective agonist ligand
The non-catechol, selective dopamine D2-agonist compound 3H-205–502 was used to localize dopamine D2 receptors by autoradiography after in vitro labeling of brain sections. The characteristics of theExpand
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Modulation of GABA binding sites by CNS depressants and CNS convulsants
[(3)H]Muscimol binding at 23 degrees C and muscimol stimulated [(3)H]flunitrazepam binding at 37 degrees C to membranes of rat cerebral cortex have been investigated. In washed membrane preparations,Expand
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Partial dopamine-agonistic and atypical neuroleptic properties of the amino-ergolines SDZ 208-911 and SDZ 208-912.
The aminoergolines SDZ 208-911 [N-[(8-alpha)-2,6-dimethylergoline-8-yl]-2,2- dimethylpropanamide] and SDZ 208-912 [N-[8-alpha)-2-chloro-6-methylergoline-8-yl]- 2,2-dimethylpropanamide] exhibitExpand
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Modulation of acetylcholine release from rat striatal slices by the GABA/benzodiazepine receptor complex.
GABA, THIP and muscimol enhance spontaneous and inhibit electrically induced release of tritium labelled compounds from rat striatal slices which have been pre-labelled with 3H-choline. Baclofen isExpand
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Serotonin synthesis with rat brain synaptosomes. Effects of serotonin and monoamineoxidase inhibitors.
  • M. Karobath
  • Chemistry, Medicine
  • Biochemical pharmacology
  • 1 May 1972
Abstract Synthesis of serotonin from tryptophan was measured in synaptosomes isolated from rat brainstem and diencephalon. Incubation with exogenous seroton adds only to small decreases in the rateExpand
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Antipsychotic drugs and dopamine-stimulated adenylate cyclase prepared from corpus striatum of rat brain.
Antipsychotic drugs and their clinically impotent congeners were examined as inhibitors of dopamine-sensitive adenylate cyclase (EC 4.6.1.1) in cell-free membrane preparations of the caudate-putamenExpand
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TAURINE UPTAKE IN SYNAPTOSOMAL FRACTIONS OF RAT CEREBRAL CORTEX 1
Abstract— [35S]Taurine was found to be accumulated in synaptosomal fractions of rat cerebral cortex. Kinetic analysis in the range of 1–800 μm‐[35S]taurine revealed at least two different uptakeExpand
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REVERSAL BY PHYSOSTIGMINE OF CLOZAPINE-INDUCED DELIRIUM
Clozapine, a new antipsychotic drug without extrapyramidal side effects and with strong sedating potency, can produce acute symptoms of central anticholinergic toxicity. The authors report thatExpand
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