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Molecular heterogeneity of benzodiazepine receptors
TLDR
It is found that in hippocampus and several other brain regions at least two different types of benzodiazepine receptors exist, each seems to be associated with a γ-aminobutyric acid (GABA) receptor.
Stimulation of benzodiazepine receptor binding by gamma-aminobutyric acid.
  • M. Karobath, G. Sperk
  • Biology, Chemistry
    Proceedings of the National Academy of Sciences…
  • 1 February 1979
TLDR
It is suggested that the described stimulation of benzodiazepine high-affinity binding is mediated by a receptor for GABA, as characterized by high-Affinity binding of GABA agonists.
Dopamine D2 receptors in the rat brain: autoradiographic visualization using a high-affinity selective agonist ligand
TLDR
The autoradiographic localization of 3H-205–502 binding sites showed high densities of dopamine D2 receptors in areas such as the glomerular layer of the olfactory bulb, the nucleus accumbens, caudate-putamen, Olfactory tubercle, the lateral septum, and the islands of Calleja.
Partial dopamine-agonistic and atypical neuroleptic properties of the amino-ergolines SDZ 208-911 and SDZ 208-912.
TLDR
SDZ 208-911 and 208-912 could be effective against both the positive and negative symptoms of schizophrenia, while exhibiting a reduced incidence of dystonic and parkinsonian side-effects, and might throw more light on the central dopaminergic status of schizophrenic subjects.
Antipsychotic drugs and dopamine-stimulated adenylate cyclase prepared from corpus striatum of rat brain.
TLDR
Of 12 neuroleptic drugs with reported antipsychotic efficacy, all inhibit stimulation of adenylate cyclase by 40 muM dopamine at micromolar concentrations, and among 14 other structurally related drugs that are not clinically effective as antippsychotic agents, 12 were almost ineffective while two drugs were moderate inhibitors of dopamine-sensitive adenYLate cyclases.
TAURINE UPTAKE IN SYNAPTOSOMAL FRACTIONS OF RAT CEREBRAL CORTEX 1
TLDR
Examination of the influence of structural analogues and putative transmitter substances indicates that the high affinity uptake of taurine into synaptosomal fractions of rat cerebral cortex is unique and highly specific.
[35S]-t-butylbicyclophosphorothionate binding sites are constituents of the gamma-aminobutyric acid benzodiazepine receptor complex
TLDR
Using conventionally prepared washed membrane fractions from rat cerebral cortex, it is confirmed that in the presence of 200 mM NaBr [35S] TBPS binds to a high affinity population of binding sites and that muscimol inhibits [ 35S]TBPS binding (IC50 0.32 microM) allosterically.
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