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- Publications
- Influence
Molecular heterogeneity of benzodiazepine receptors
- W. Sieghart, M. Karobath
- Chemistry, Medicine
- Nature
- 17 July 1980
Benzodiazepines exhibit reversible, stereospecific high affinity binding to mammalian brain membranes, and the respective binding sites for 3H-flunitrazepam represent pharmacologically and clinically… Expand
Stimulation of benzodiazepine receptor binding by gamma-aminobutyric acid.
- M. Karobath, G. Sperk
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences…
- 1 February 1979
The effect of the neurotransmitter gamma-aminobutyric acid (GABA) on high-affinity binding of benzodiazepines to brain membranes has been investigated. GABA stimulated [3H]diazepam binding by more… Expand
Dopamine D2 receptors in the rat brain: autoradiographic visualization using a high-affinity selective agonist ligand
- C. Charuchinda, P. Supavilai, M. Karobath, J. Palacios
- Biology, Medicine
- The Journal of neuroscience : the official…
- 1 May 1987
The non-catechol, selective dopamine D2-agonist compound 3H-205–502 was used to localize dopamine D2 receptors by autoradiography after in vitro labeling of brain sections. The characteristics of the… Expand
Modulation of GABA binding sites by CNS depressants and CNS convulsants
- P. Supavilai, A. Mannonen, M. Karobath
- Chemistry, Medicine
- Neurochemistry International
- 31 December 1982
[(3)H]Muscimol binding at 23 degrees C and muscimol stimulated [(3)H]flunitrazepam binding at 37 degrees C to membranes of rat cerebral cortex have been investigated. In washed membrane preparations,… Expand
Partial dopamine-agonistic and atypical neuroleptic properties of the amino-ergolines SDZ 208-911 and SDZ 208-912.
- D. M. Coward, A. Dixon, +4 authors G. Shearman
- Chemistry, Medicine
- The Journal of pharmacology and experimental…
- 1990
The aminoergolines SDZ 208-911 [N-[(8-alpha)-2,6-dimethylergoline-8-yl]-2,2- dimethylpropanamide] and SDZ 208-912 [N-[8-alpha)-2-chloro-6-methylergoline-8-yl]- 2,2-dimethylpropanamide] exhibit… Expand
Modulation of acetylcholine release from rat striatal slices by the GABA/benzodiazepine receptor complex.
- P. Supavilai, M. Karobath
- Chemistry, Medicine
- Life sciences
- 4 February 1985
GABA, THIP and muscimol enhance spontaneous and inhibit electrically induced release of tritium labelled compounds from rat striatal slices which have been pre-labelled with 3H-choline. Baclofen is… Expand
Serotonin synthesis with rat brain synaptosomes. Effects of serotonin and monoamineoxidase inhibitors.
- M. Karobath
- Chemistry, Medicine
- Biochemical pharmacology
- 1 May 1972
Abstract Synthesis of serotonin from tryptophan was measured in synaptosomes isolated from rat brainstem and diencephalon. Incubation with exogenous seroton adds only to small decreases in the rate… Expand
Antipsychotic drugs and dopamine-stimulated adenylate cyclase prepared from corpus striatum of rat brain.
- M. Karobath, H. Leitich
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences…
- 1 July 1974
Antipsychotic drugs and their clinically impotent congeners were examined as inhibitors of dopamine-sensitive adenylate cyclase (EC 4.6.1.1) in cell-free membrane preparations of the caudate-putamen… Expand
TAURINE UPTAKE IN SYNAPTOSOMAL FRACTIONS OF RAT CEREBRAL CORTEX 1
- R. Schmid, W. Sieghart, M. Karobath
- Chemistry, Medicine
- Journal of neurochemistry
- 1 July 1975
Abstract— [35S]Taurine was found to be accumulated in synaptosomal fractions of rat cerebral cortex. Kinetic analysis in the range of 1–800 μm‐[35S]taurine revealed at least two different uptake… Expand
REVERSAL BY PHYSOSTIGMINE OF CLOZAPINE-INDUCED DELIRIUM
- P. Schuster, E. Gabriel, Bernd Kufferle, M. Karobath
- Medicine
- The Lancet
- 3 January 1976
Clozapine, a new antipsychotic drug without extrapyramidal side effects and with strong sedating potency, can produce acute symptoms of central anticholinergic toxicity. The authors report that… Expand