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Molecular heterogeneity of benzodiazepine receptors
It is found that in hippocampus and several other brain regions at least two different types of benzodiazepine receptors exist, each seems to be associated with a γ-aminobutyric acid (GABA) receptor.
Stimulation of benzodiazepine receptor binding by gamma-aminobutyric acid.
- M. Karobath, G. Sperk
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 1 February 1979
It is suggested that the described stimulation of benzodiazepine high-affinity binding is mediated by a receptor for GABA, as characterized by high-Affinity binding of GABA agonists.
Modulation of GABA binding sites by CNS depressants and CNS convulsants
Dopamine D2 receptors in the rat brain: autoradiographic visualization using a high-affinity selective agonist ligand
- C. Charuchinda, P. Supavilai, M. Karobath, J. Palacios
- Biology, ChemistryThe Journal of neuroscience : the official…
- 1 May 1987
The autoradiographic localization of 3H-205–502 binding sites showed high densities of dopamine D2 receptors in areas such as the glomerular layer of the olfactory bulb, the nucleus accumbens, caudate-putamen, Olfactory tubercle, the lateral septum, and the islands of Calleja.
Partial dopamine-agonistic and atypical neuroleptic properties of the amino-ergolines SDZ 208-911 and SDZ 208-912.
SDZ 208-911 and 208-912 could be effective against both the positive and negative symptoms of schizophrenia, while exhibiting a reduced incidence of dystonic and parkinsonian side-effects, and might throw more light on the central dopaminergic status of schizophrenic subjects.
Serotonin synthesis with rat brain synaptosomes. Effects of serotonin and monoamineoxidase inhibitors.
- M. Karobath
- Biology, ChemistryBiochemical pharmacology
- 1 May 1972
Antipsychotic drugs and dopamine-stimulated adenylate cyclase prepared from corpus striatum of rat brain.
- M. Karobath, H. Leitich
- Biology, PsychologyProceedings of the National Academy of Sciences…
- 1 July 1974
Of 12 neuroleptic drugs with reported antipsychotic efficacy, all inhibit stimulation of adenylate cyclase by 40 muM dopamine at micromolar concentrations, and among 14 other structurally related drugs that are not clinically effective as antippsychotic agents, 12 were almost ineffective while two drugs were moderate inhibitors of dopamine-sensitive adenYLate cyclases.
TAURINE UPTAKE IN SYNAPTOSOMAL FRACTIONS OF RAT CEREBRAL CORTEX 1
Examination of the influence of structural analogues and putative transmitter substances indicates that the high affinity uptake of taurine into synaptosomal fractions of rat cerebral cortex is unique and highly specific.
REVERSAL BY PHYSOSTIGMINE OF CLOZAPINE-INDUCED DELIRIUM
[35S]-t-butylbicyclophosphorothionate binding sites are constituents of the gamma-aminobutyric acid benzodiazepine receptor complex
Using conventionally prepared washed membrane fractions from rat cerebral cortex, it is confirmed that in the presence of 200 mM NaBr [35S] TBPS binds to a high affinity population of binding sites and that muscimol inhibits [ 35S]TBPS binding (IC50 0.32 microM) allosterically.