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lasiocarpine

National Institutes of Health

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Pyrrolizidine Alkaloids

Papers overview

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Review
2017
Review
2017
Risk assessment for pyrrolizidine alkaloids detected in (herbal) teas and plant food supplements
1992
1992
Detection of sulphur-conjugated pyrrolic metabolites in blood and fresh or fixed liver tissue from rats given a variety of toxic pyrrolizidine alkaloids.
1985
1985
Initiation and selection of resistant hepatocyte nodules in rats given the pyrrolizidine alkaloids lasiocarpine and senecionine.
The biological mechanisms by which pyrrolizidine alkaloids contribute to initiation and nodule selection (promotion) steps in… 
1980
1980
Chromosomal aberrations and mutation in cultured mammalian cells induced by pyrrolizidine alkaloids.
1978
1978
Bioassay of lasiocarpine for possible carcinogenicity.
A bioassay of lasiocarpine for possible carcinogenicity was conducted by administering the test chemical in the diet to Fischer… 
1976
1976
Rapid development of hyperplastic nodules and cirrhosis in the liver of rats treated concurrently with thioacetamide and the pyrrolizidine alkaloid lasiocarpine
Pyrrolizidine alkaloids have long been considered to be hepatotoxic in man as well as in grazing animals. To investigate the… 
Highly Cited
1972
Highly Cited
1972
Malignant tumors in rats given lasiocarpine.
Summary Lasiocarpine was injected i.p. into rats in doses of 7.8 mg/kg body weight (50% lethal dose of 0.1) twice weekly for 4… 
1971
1971
Isolation and biological activity of mammalian helical polyribosomes.
1971
1971
Hepatic megalocytosis in chronic lasiocarpine poisoning. Some functional studies.
In an attempt to understand the nature of cytoplasmic and nuclear enlargement of liver cells designated as megalocytosis that… 
1970
1970
Persistance de la synthèse de RNA extranucléolaires dans le foie de rats traités par la lasiocarpine. étude par autoradiographie a haute résolution
La synthèse résiduelle de RNA dans le foie de rats soumis à une injection de lasiocarpine a été étudiée par autoradiographie… 
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