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Tissue distribution of quercetin in rats and pigs.
These studies have for the first time identified target tissues of quercetin, which may help to understand its mechanisms of action in vivo, and identify its availability to tissues.
Regioselectivity of phase II metabolism of luteolin and quercetin by UDP-glucuronosyl transferases.
Regioselectivity is dependent on the model flavonoid of interest, glucuronidation of luteolin and quercetin not following the same pattern, depending on the isoenzyme of UDP-glucuronosyltransferases (UGT), and the human intestine UGT's appear to be especially effective in conjugating this 3',4' catechol unit.
Behaviour of silver nanoparticles and silver ions in an in vitro human gastrointestinal digestion model
These AgNPs under physiological conditions can reach the intestinal wall in their initial size and composition, and intestinal digestion of AgNO3 in presence of proteins resulted in particle formation.
Identification of 14 quercetin phase II mono- and mixed conjugates and their formation by rat and human phase II in vitro model systems.
It is concluded that none of the in vitro models converted quercetin to a phase II metabolite mixture similar to the in vivo plasma metabolite pattern of quercets, opening the way for a better-funded assessment of the biological activity of quERCetin in various biological systems.
The use of in vitro toxicity data and physiologically based kinetic modeling to predict dose-response curves for in vivo developmental toxicity of glycol ethers in rat and man.
An approach to predict in vivo dose-response curves for developmental toxicity by combining in vitro toxicity data and in silico kinetic modeling is shown, which could provide a means to reduce the need for animal testing in human risk assessment practices.
Update of risk assessments of main marine biotoxins in the European Union.