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Chemistry and Toxicology of Pyrrolizidine Alkaloids
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Toxicity of Pyrrolizidine Alkaloids
A new class of metabolite, with a pyrrole-like structure, has been demonstrated in the tissues of animals poisoned by pyrrolizidine alkaloids. There is some correlation between the degree ofExpand
  • 442
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Spectrophotometric determination of unsaturated pyrrolizidine alkaloids.
  • A. Mattocks
  • Chemistry, Medicine
  • Analytical chemistry
  • 1 April 1967
  • 139
  • 4
Simple procedures for preparing putative toxic metabolites of pyrrolizidine alkaloids.
New procedures are described for converting unsaturated pyrrolizidine alkaloids to chemically reactive pyrrolic esters (dehydro-alkaloids), which are probable primary toxic metabolites formed fromExpand
  • 110
  • 4
Detection of pyrrolizidine alkaloids on thin-layer chromatograms.
  • A. Mattocks
  • Chemistry, Medicine
  • Journal of chromatography
  • 1967
  • 79
  • 3
An epidemic of veno-occlusive disease of the liver in Afghanistan. Pathologic features.
A large outbreak of veno-occlusive disease occurred in Afghanistan in which approximately 7,800 in a population of 35,000 subjects were estimated to have been affected. It was caused by consumptionExpand
  • 31
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The conversion of the pyrrolizidine alkaloid retrorsine to pyrrolic derivatives in vivo and in vitro and its acute toxicity to various animal species.
Abstract 1. (1)|The acute toxicity of retrorsine to mice, hamsters, guinea pigs, fowl and quail has been determined. Approximate LD 50 values varied from 65 mg/kg in the mouse to 279 mg/kg in quail.Expand
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Pyrrolic and N-oxide metabolites formed from pyrrolizidine alkaloids by hepatic microsomes in vitro: relevance to in vivo hepatotoxicity.
An analytical method of improved sensitivity has enabled measurements to be made of N-oxide as well as pyrrolic metabolites formed from a range of unsaturated pyrrolizidine alkaloids in hepaticExpand
  • 55
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Pyrrolic metabolites from non-toxic pyrrolizidine alkaloids.
THERE is evidence that some or all of the cytotoxic effects of unsaturated pyrrolizidine alkaloids are, in some animals, caused by pyrrolic metabolites formed by enzymatic dehydro-genation of theExpand
  • 26
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Hepatotoxic effects due to pyrrolizidine alkaloid N-oxides.
  • A. Mattocks
  • Chemistry, Medicine
  • Xenobiotica; the fate of foreign compounds in…
  • 1971
  • 47
  • 2
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