Share This Author
Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development.
- J. Schmidt, G. Su, J. Reddy, M. Simon, C. Bradfield
- BiologyProceedings of the National Academy of Sciences…
- 25 June 1996
The Ah receptor (AHR) is a ligand-activated transcription factor that mediates a pleiotropic response to environmental contaminants such as benzo[a]pyrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin. In…
International Union of Pharmacology. LXI. Peroxisome Proliferator-Activated Receptors
The three peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors of the nuclear hormone receptor superfamily. They share a high degree of structural homology…
PEROXISOMAL β-OXIDATION AND PEROXISOME PROLIFERATOR–ACTIVATED RECEPTOR α: An Adaptive Metabolic System
The β-Oxidation chain shortening of long-chain and very-long-chain fatty acyl-coenzyme (CoAs) and dicarboxylic acids that serve as substrates for peroxisomal β-oxidation are studied.
Peroxisomal beta-oxidation and peroxisome proliferator-activated receptor alpha: an adaptive metabolic system.
Evidence derived from mice deficient in PPAR alpha, peroxisomal fatty acyl-CoA oxidase, and some of the other enzymes of the two per oxisomal beta-oxidation pathways points to the critical importance of PPARalpha and of the classical perox isome proliferator-activated receptor alpha in energy metabolism, and in the development of hepatic steatosis, steatohepatitis, and liver cancer.
Application of comparative functional genomics to identify best-fit mouse models to study human cancer
The approach can effectively identify appropriate mouse models to study human cancers and expression patterns in HCCs from Myc Tgfa transgenic mice and in diethylnitrosamine-induced mice were most similar to those of the poorer survival group of human H CCs.
Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor gamma1 (PPARgamma1) overexpression.
It is suggested that a high level of PPARgamma in mouse liver is sufficient for the induction of adipogenic transformation of hepatocytes with adipose tissue-specific gene expression and lipid accumulation.
Structural organization of mouse peroxisome proliferator-activated receptor gamma (mPPAR gamma) gene: alternative promoter use and different splicing yield two mPPAR gamma isoforms.
The results establish that at least one of the PPAR genes yields more than one protein product, similar to that encountered with retinoid X receptor and retinoic acid receptor genes.
Carcinogenesis by hepatic peroxisome proliferators: evaluation of the risk of hypolipidemic drugs and industrial plasticizers to humans.
In this critical review, careful consideration will be given to the hypothesis that "potent hepatic peroxisome proliferators as a class are carcinogenic," and particular attention will be paid to the possible role of peroxISome proliferation-mediated radical toxicity and generation of endogenous initiators of carcinogenesis.
Isolation and Characterization of PBP, a Protein That Interacts with Peroxisome Proliferator-activated Receptor*
- Yi-jun Zhu, Chao Qi, Sanjay K. Jain, M. Rao, J. Reddy
- BiologyJournal of Biological Chemistry
- 10 October 1997
PBP modestly increased the transcriptional activity of PPARγ, and a truncated form of PBP acted as a dominant-negative repressor, suggesting that PBP is a genuine coactivator for PPAR.
Peroxisome proliferator-activated receptor alpha mediates the effects of high-fat diet on hepatic gene expression.
PPARalpha and PPARalpha-signaling are activated in liver by chronic high-fat feeding; PPARgamma may compensate for PPAR Alpha in PPAR alpha null mice on HFD; and Adenoviral overexpression of PPargamma in liver indicated that PPARGamma can up-regulate genes involved in lipo/adipogenesis but also characteristic PPARAlpha targets involved in fatty acid oxidation.