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New principle for the analysis of chemical carcinogenesis
THE development of cancer following exposure to chemical carcinogens or to various forms of irradiation is almost invariably slow and prolonged. Although the process can be initiated by a briefExpand
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Rapid emergence of carcinogen-induced hyperplastic lesions in a new model for the sequential analysis of liver carcinogenesis.
Hyperplastic liver lesions which develop following administration of hepatocarcinogens have been implicated as probable precursors for the cancers which ultimately develop. Some, and possibly all, ofExpand
  • 550
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The multistep nature of cancer development.
  • E. Farber
  • Medicine
  • Cancer research
  • 1 October 1984
  • 550
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  • PDF
Hepatocarcinogenesis: a dynamic cellular perspective.
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The sequential analysis of liver cancer induction.
  • E. Farber
  • Medicine
  • Biochimica et biophysica acta
  • 6 May 1980
  • 350
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Induction of resistant hepatocytes as a new principle for a possible short-term in vivo test for carcinogens.
The induction of resistant hepatocytes in vivo in the rat has been observed with 21 different chemical carcinogens. The resistance was measured by the ability of the cells to proliferate as focalExpand
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Initiation of chemical carcinogenesis requires cell proliferation
CELL proliferation has often been implicated in the development of cancer with chemicals1–3. Supportive evidence for this is the observation that several carcinogens that normally do not induce liverExpand
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HISTOCHEMICAL LOCALIZATION OF SPECIFIC OXIDATIVE ENZYMES I. TETRAZOLIUM STAINS FOR DIPHOSPHOPYRIDINE NUCLEOTIDE DIAPHORASE AND TRIPHOSPHOPYRIDINE NUCLEOTIDE DIAPHORASE
Few satisfactory methods for the histochemical localization of oxidative enzymes have been developed, largely because oxidation-reduction indicators suitable for histochemical use have not beenExpand
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Carcinogenesis--cellular evolution as a unifying thread: Presidential address.
  • E. Farber
  • Biology, Medicine
  • Cancer research
  • 1 November 1973
  • 152
  • 3
HISTOCHEMICAL LOCALIZATION OF SPECIFIC OXIDATIVE ENZYMES III. EVALUATION STUDIES OF TETRAZOLIUM STAINING METHODS FOR DIPHOSPHOPYRIDINE NUCLEOTIDE DIAPHORASE, TRIPHOSPHOPYRIDINE NUCLEOTIDE DIAPHORASE
Histochemical stains are methods for the visual demonstration of the biochemical properties of organized tissues. They differ from "ordinary" tissue stains only in so far as they lend themselves toExpand
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