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New principle for the analysis of chemical carcinogenesis
TLDR
It is not known what the critical property (or properties) is that makes initiated cells so important in carcinogens and the failure to understand and manipulate this early step has been a major impediment to its analysis.
The sequential analysis of cancer development.
Rapid emergence of carcinogen-induced hyperplastic lesions in a new model for the sequential analysis of liver carcinogenesis.
TLDR
An in vivo assay system based on this phenomenon of "selective resistance to cytotoxicity" should prove valuable in answering specific questions about the carcinogenic process in liver and possibly in other tissues.
The multistep nature of cancer development.
  • E. Farber
  • Medicine
    Cancer research
  • 1 October 1984
Carcinogen-induced mdr overexpression is associated with xenobiotic resistance in rat preneoplastic liver nodules and hepatocellular carcinomas.
TLDR
Examination of the expression of mdr sequences in rat livers under a variety of experimental conditions suggests that overexpression of mDr, a gene previously associated with resistance to antineoplastic agents, may also be involved in the development of resistance to xenobiotics in rat hyperplastic nodules.
Clonal adaptation during carcinogenesis.
  • E. Farber
  • Medicine
    Biochemical pharmacology
  • 15 June 1990
Initiation of chemical carcinogenesis requires cell proliferation
TLDR
A new approach to the sequential analysis of carcinogenesis in vivo is developed that delineates the first few steps in the process and is a quantitative assay for initiation of liver cancer, to investigate whether cell replication exerts its first effect on initiation or on some later step in the carcinogenic process.
Induction of resistant hepatocytes as a new principle for a possible short-term in vivo test for carcinogens.
TLDR
The presumptive preneoplastic nature of the resistant hepatocytes and the possible usefulness of this approach for the development of a new in vivo short-term test system for carcinogens are discussed.
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