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insulin receptor substrate 1 protein

Known as: IRS1, Insulin Receptor Substrate 1, IRS-1 
Insulin receptor substrate 1 (1242 aa, ~132 kDa) is encoded by the human IRS1 gene. This protein is involved in insulin-mediated signaling.
National Institutes of Health

Papers overview

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Highly Cited
2001
Highly Cited
2001
Molecular scanning of human IRS‐1 gene revealed a common polymorphism causing Gly →Arg972 change. Diabetic and pre‐diabetic… 
Highly Cited
2001
Highly Cited
2001
LNCaP cells are human prostatic cancer cells that have a frame-shift mutation of the tumor suppressor gene PTEN and do not… 
Highly Cited
1999
Highly Cited
1999
Insulin receptor substrate (IRS) proteins are important intracellular molecules that mediate insulin receptor tyrosine kinase… 
Highly Cited
1998
Highly Cited
1998
Insulin receptor substrate-1 (IRS-1) is phosphorylated on multiple tyrosine residues by ligand-activated insulin receptors. These… 
Highly Cited
1997
Highly Cited
1997
Signal transduction by insulin and IGF-1, several interleukins (IL-2, IL-4, IL-9, IL-13), interferons, GH, and other cytokines… 
Highly Cited
1996
Highly Cited
1996
Insulin receptor substrate 2 (IRS-2) has recently been shown to be a substrate of the insulin receptor (IR). In this study we… 
Highly Cited
1995
Highly Cited
1995
Insulin stimulation of 3T3-L1 adipocytes results in rapid activation of the insulin receptor tyrosine kinase followed by… 
Highly Cited
1995
Highly Cited
1995
Insulin signal transduction involves the multisite docking protein insulin receptor substrate-1 (IRS-1) and a number of Src… 
Highly Cited
1995