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insulin receptor substrate 1 protein
Known as:
IRS1
, Insulin Receptor Substrate 1
, IRS-1
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Insulin receptor substrate 1 (1242 aa, ~132 kDa) is encoded by the human IRS1 gene. This protein is involved in insulin-mediated signaling.
National Institutes of Health
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Related topics
Related topics
11 relations
Adaptor Signaling Protein Gene
Growth Hormone Signaling Pathway
IGF-1 Signaling Pathway
IL4 Signaling Pathway
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Broader (1)
Insulin Receptor Substrate Proteins
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2001
Highly Cited
2001
The common Arg972 polymorphism in insulin receptor substrate‐1 causes apoptosis of human pancreatic islets
M. Federici
,
Marta L. Hribal
,
+8 authors
G. Sesti
The FASEB Journal
2001
Corpus ID: 44976340
Molecular scanning of human IRS‐1 gene revealed a common polymorphism causing Gly →Arg972 change. Diabetic and pre‐diabetic…
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Highly Cited
2001
Highly Cited
2001
Mechanisms of regulation of cell adhesion and motility by insulin receptor substrate-1 in prostate cancer cells
K. Reiss
,
Jinya Wang
,
G. Romano
,
X. Tu
,
F. Peruzzi
,
R. Baserga
Oncogene
2001
Corpus ID: 19294187
LNCaP cells are human prostatic cancer cells that have a frame-shift mutation of the tumor suppressor gene PTEN and do not…
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Highly Cited
1999
Highly Cited
1999
Insulin-induced insulin receptor substrate-1 degradation is mediated by the proteasome degradation pathway.
Xiao Jian Sun
,
J. Goldberg
,
L.-Y. Qiao
,
John J. Mitchell
Diabetes
1999
Corpus ID: 12510933
Insulin receptor substrate (IRS) proteins are important intracellular molecules that mediate insulin receptor tyrosine kinase…
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Highly Cited
1998
Highly Cited
1998
A Rho-associated Protein Kinase, ROKα, Binds Insulin Receptor Substrate-1 and Modulates Insulin Signaling*
S. Farah
,
Y. Agazie
,
N. Ohan
,
Johnny K. Ngsee
,
X. J. Liu
Journal of Biological Chemistry
1998
Corpus ID: 45691879
Insulin receptor substrate-1 (IRS-1) is phosphorylated on multiple tyrosine residues by ligand-activated insulin receptors. These…
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Highly Cited
1997
Highly Cited
1997
The IRS-2 gene on murine chromosome 8 encodes a unique signaling adapter for insulin and cytokine action.
X. Sun
,
S. Pons
,
+9 authors
M. White
Molecular Endocrinology
1997
Corpus ID: 10172819
Signal transduction by insulin and IGF-1, several interleukins (IL-2, IL-4, IL-9, IL-13), interferons, GH, and other cytokines…
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Highly Cited
1996
Highly Cited
1996
Interaction of Insulin Receptor Substrate-2 (IRS-2) with the Insulin and Insulin-like Growth Factor I Receptors
Weimin He
,
A. Craparo
,
+4 authors
T. A. Gustafson
Journal of Biological Chemistry
1996
Corpus ID: 12092880
Insulin receptor substrate 2 (IRS-2) has recently been shown to be a substrate of the insulin receptor (IR). In this study we…
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Highly Cited
1995
Highly Cited
1995
Insulin Regulation of Membrane-associated Insulin Receptor Substrate 1 (*)
R. Heller-Harrison
,
M. Morin
,
M. Czech
Journal of Biological Chemistry
1995
Corpus ID: 24151548
Insulin stimulation of 3T3-L1 adipocytes results in rapid activation of the insulin receptor tyrosine kinase followed by…
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Highly Cited
1995
Highly Cited
1995
Adapter Function of Protein-tyrosine Phosphatase 1D in Insulin Receptor/Insulin Receptor Substrate-1 Interaction (*)
A. Kharitonenkov
,
J. Schnekenburger
,
+5 authors
A. Ullrich
Journal of Biological Chemistry
1995
Corpus ID: 39400172
Insulin signal transduction involves the multisite docking protein insulin receptor substrate-1 (IRS-1) and a number of Src…
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Highly Cited
1995
Highly Cited
1995
The inability of phosphatidylinositol 3-kinase activation to stimulate GLUT4 translocation indicates additional signaling pathways are required for insulin-stimulated glucose uptake.
S. Isakoff
,
C. Taha
,
E. Rose
,
J. Marcusohn
,
Amira Klip
,
E. Skolnik
Proceedings of the National Academy of Sciences…
1995
Corpus ID: 44505995
Recent experimental evidence has focused attention to the role of two molecules, insulin receptor substrate 1 (IRS-1) and…
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Highly Cited
1994
Highly Cited
1994
Insulin receptor substrate 1 mediates the stimulatory effect of insulin on GLUT4 translocation in transfected rat adipose cells.
M. Quon
,
A. Butte
,
M. Zarnowski
,
G. Sesti
,
S. Cushman
,
S. Taylor
Journal of Biological Chemistry
1994
Corpus ID: 19543305
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