insulin receptor substrate 1 protein

Stimulation of the insulin and insulin-like growth factor I (IGF-I) receptor activates the phosphoinositide-3-kinase/Akt/mTOR… Expand

Type 2 diabetes mellitus has become an epidemic, and virtually no physician is without patients who have the disease. Whereas… Expand

Obesity contributes to the development of type 2 diabetes, but the underlying mechanisms are poorly understood. Using cell… Expand

ABSTRACT Insulin resistance is a pathophysiological component of type 2 diabetes and obesity and also occurs in states of stress… Expand

Insulin-like growth factors elicit many responses through activation of phosphoinositide 3-OH kinase (PI3K). The tuberous… Expand

Recent studies have demonstrated that fatty acids induce insulin resistance in skeletal muscle by blocking insulin activation of… Expand

Tumor necrosis factor α (TNFα) inhibits insulin action, in part, through serine phosphorylation of IRS proteins; however, the… Expand

INSULIN receptor substrate-1 (IRS-1) is the major substrate of insulin receptor and IGF-1 receptor tyrosine kinases; it has an… Expand

THE principal substrate for the insulin and insulin-like growth factor-1 (IGF-1) receptors is the cytoplasmic protein insulin… Expand

SINCE the discovery of insulin nearly 70 years ago, there has been no problem more fundamental to diabetes research than… Expand