insulin receptor substrate 1 protein

Known as: IRS1, Insulin Receptor Substrate 1, IRS-1 
Insulin receptor substrate 1 (1242 aa, ~132 kDa) is encoded by the human IRS1 gene. This protein is involved in insulin-mediated signaling.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1984-2018
010020019842018

Papers overview

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Highly Cited
2007
Highly Cited
2007
Inflammation is associated with obesity and insulin resistance. Proinflammatory cytokines produced by adipose tissue in obesity… (More)
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Highly Cited
2006
Highly Cited
2006
Stimulation of the insulin and insulin-like growth factor I (IGF-I) receptor activates the phosphoinositide-3-kinase/Akt/mTOR… (More)
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Highly Cited
2004
Highly Cited
2004
Obesity contributes to the development of type 2 diabetes, but the underlying mechanisms are poorly understood. Using cell… (More)
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Highly Cited
2003
Highly Cited
2003
Several studies have shown a relationship between interleukin (IL) 6 levels and insulin resistance. We here show that human… (More)
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Highly Cited
2002
Highly Cited
2002
Recent studies have demonstrated that fatty acids induce insulin resistance in skeletal muscle by blocking insulin activation of… (More)
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Highly Cited
2002
Highly Cited
2002
Serine phosphorylation of insulin receptor substrate-1 (IRS-1) inhibits insulin signal transduction in a variety of cell… (More)
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Highly Cited
2000
Highly Cited
2000
Tumor necrosis factor alpha (TNFalpha) inhibits insulin action, in part, through serine phosphorylation of IRS proteins; however… (More)
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Highly Cited
1994
Highly Cited
1994
INSULIN receptor substrate-1 (IRS-1) is the major substrate of insulin receptor and IGF-1 receptor tyrosine kinases; it has an… (More)
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Highly Cited
1994
Highly Cited
1994
THE principal substrate for the insulin and insulin-like growth factor-1 (IGF-1) receptors is the cytoplasmic protein insulin… (More)
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Highly Cited
1991
Highly Cited
1991
SINCE the discovery of insulin nearly 70 years ago, there has been no problem more fundamental to diabetes research than… (More)
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