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insulin receptor substrate 1 protein

Known as: IRS1, Insulin Receptor Substrate 1, IRS-1 
Insulin receptor substrate 1 (1242 aa, ~132 kDa) is encoded by the human IRS1 gene. This protein is involved in insulin-mediated signaling.
National Institutes of Health

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Highly Cited
2006
Highly Cited
2006
Stimulation of the insulin and insulin-like growth factor I (IGF-I) receptor activates the phosphoinositide-3-kinase/Akt/mTOR… Expand
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Review
2005
Review
2005
Type 2 diabetes mellitus has become an epidemic, and virtually no physician is without patients who have the disease. Whereas… Expand
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Highly Cited
2004
Highly Cited
2004
Obesity contributes to the development of type 2 diabetes, but the underlying mechanisms are poorly understood. Using cell… Expand
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Highly Cited
2004
Highly Cited
2004
ABSTRACT Insulin resistance is a pathophysiological component of type 2 diabetes and obesity and also occurs in states of stress… Expand
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Highly Cited
2004
Highly Cited
2004
Insulin-like growth factors elicit many responses through activation of phosphoinositide 3-OH kinase (PI3K). The tuberous… Expand
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Highly Cited
2002
Highly Cited
2002
Recent studies have demonstrated that fatty acids induce insulin resistance in skeletal muscle by blocking insulin activation of… Expand
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Highly Cited
2000
Highly Cited
2000
Tumor necrosis factor α (TNFα) inhibits insulin action, in part, through serine phosphorylation of IRS proteins; however, the… Expand
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Highly Cited
1994
Highly Cited
1994
INSULIN receptor substrate-1 (IRS-1) is the major substrate of insulin receptor and IGF-1 receptor tyrosine kinases; it has an… Expand
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Highly Cited
1994
Highly Cited
1994
THE principal substrate for the insulin and insulin-like growth factor-1 (IGF-1) receptors is the cytoplasmic protein insulin… Expand
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Highly Cited
1991
Highly Cited
1991
SINCE the discovery of insulin nearly 70 years ago, there has been no problem more fundamental to diabetes research than… Expand
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