FAQ

insulin receptor substrate 1 protein

Known as: IRS1, Insulin Receptor Substrate 1, IRS-1 
Insulin receptor substrate 1 (1242 aa, ~132 kDa) is encoded by the human IRS1 gene. This protein is involved in insulin-mediated signaling.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1984-2018
010020019842018

Related topics

Related topics

11 relations
Adaptor Signaling Protein GeneGrowth Hormone Signaling PathwayIGF-1 Signaling PathwayIL4 Signaling Pathway
(More)

Broader (1)

Insulin Receptor Substrate Proteins

Related mentions per year

Related mentions per year

1946-2018
19401960198020002020
insulin receptor substrate 1 protein
Signal Transduction
protein protein interaction
IRS1 gene
Signaling Protein
IGF-1 Signaling Pathway

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Interleukin-1beta-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression.
Inflammation is associated with obesity and insulin resistance. Proinflammatory cytokines produced by adipose tissue in obesity… (More)
Is this relevant?
Highly Cited
2006
Highly Cited
2006
mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt.
Stimulation of the insulin and insulin-like growth factor I (IGF-I) receptor activates the phosphoinositide-3-kinase/Akt/mTOR… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes.
Obesity contributes to the development of type 2 diabetes, but the underlying mechanisms are poorly understood. Using cell… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2003
Highly Cited
2003
Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects.
Several studies have shown a relationship between interleukin (IL) 6 levels and insulin resistance. We here show that human… (More)
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle.
Recent studies have demonstrated that fatty acids induce insulin resistance in skeletal muscle by blocking insulin activation of… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 5
  • figure 4
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action.
Serine phosphorylation of insulin receptor substrate-1 (IRS-1) inhibits insulin signal transduction in a variety of cell… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2000
Highly Cited
2000
The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307).
Tumor necrosis factor alpha (TNFalpha) inhibits insulin action, in part, through serine phosphorylation of IRS proteins; however… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1994
Highly Cited
1994
Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1
INSULIN receptor substrate-1 (IRS-1) is the major substrate of insulin receptor and IGF-1 receptor tyrosine kinases; it has an… (More)
Is this relevant?
Highly Cited
1994
Highly Cited
1994
Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene
THE principal substrate for the insulin and insulin-like growth factor-1 (IGF-1) receptors is the cytoplasmic protein insulin… (More)
Is this relevant?
Highly Cited
1991
Highly Cited
1991
Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein
SINCE the discovery of insulin nearly 70 years ago, there has been no problem more fundamental to diabetes research than… (More)
Is this relevant?