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insulin receptor substrate 1 protein

Known as: IRS1, Insulin Receptor Substrate 1, IRS-1 
Insulin receptor substrate 1 (1242 aa, ~132 kDa) is encoded by the human IRS1 gene. This protein is involved in insulin-mediated signaling.
National Institutes of Health

Related topics

Related topics

11 relations
Adaptor Signaling Protein GeneGrowth Hormone Signaling PathwayIGF-1 Signaling PathwayIL4 Signaling Pathway

Broader (1)

Insulin Receptor Substrate Proteins

Papers overview

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Highly Cited
2001
Highly Cited
2001
The common Arg972 polymorphism in insulin receptor substrate‐1 causes apoptosis of human pancreatic islets
Molecular scanning of human IRS‐1 gene revealed a common polymorphism causing Gly →Arg972 change. Diabetic and pre‐diabetic… 
Highly Cited
2001
Highly Cited
2001
Mechanisms of regulation of cell adhesion and motility by insulin receptor substrate-1 in prostate cancer cells
LNCaP cells are human prostatic cancer cells that have a frame-shift mutation of the tumor suppressor gene PTEN and do not… 
Highly Cited
1999
Highly Cited
1999
Insulin-induced insulin receptor substrate-1 degradation is mediated by the proteasome degradation pathway.
Insulin receptor substrate (IRS) proteins are important intracellular molecules that mediate insulin receptor tyrosine kinase… 
Highly Cited
1998
Highly Cited
1998
A Rho-associated Protein Kinase, ROKα, Binds Insulin Receptor Substrate-1 and Modulates Insulin Signaling*
Insulin receptor substrate-1 (IRS-1) is phosphorylated on multiple tyrosine residues by ligand-activated insulin receptors. These… 
Highly Cited
1997
Highly Cited
1997
The IRS-2 gene on murine chromosome 8 encodes a unique signaling adapter for insulin and cytokine action.
Signal transduction by insulin and IGF-1, several interleukins (IL-2, IL-4, IL-9, IL-13), interferons, GH, and other cytokines… 
Highly Cited
1996
Highly Cited
1996
Interaction of Insulin Receptor Substrate-2 (IRS-2) with the Insulin and Insulin-like Growth Factor I Receptors
Insulin receptor substrate 2 (IRS-2) has recently been shown to be a substrate of the insulin receptor (IR). In this study we… 
Highly Cited
1995
Highly Cited
1995
Insulin Regulation of Membrane-associated Insulin Receptor Substrate 1 (*)
Insulin stimulation of 3T3-L1 adipocytes results in rapid activation of the insulin receptor tyrosine kinase followed by… 
Highly Cited
1995
Highly Cited
1995
Adapter Function of Protein-tyrosine Phosphatase 1D in Insulin Receptor/Insulin Receptor Substrate-1 Interaction (*)
Insulin signal transduction involves the multisite docking protein insulin receptor substrate-1 (IRS-1) and a number of Src… 
Highly Cited
1995
Highly Cited
1995
The inability of phosphatidylinositol 3-kinase activation to stimulate GLUT4 translocation indicates additional signaling pathways are required for insulin-stimulated glucose uptake.
Recent experimental evidence has focused attention to the role of two molecules, insulin receptor substrate 1 (IRS-1) and… 
Highly Cited
1994
Highly Cited
1994
Insulin receptor substrate 1 mediates the stimulatory effect of insulin on GLUT4 translocation in transfected rat adipose cells.
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