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insulin receptor substrate 1 protein

Known as: IRS1, Insulin Receptor Substrate 1, IRS-1 
Insulin receptor substrate 1 (1242 aa, ~132 kDa) is encoded by the human IRS1 gene. This protein is involved in insulin-mediated signaling.
National Institutes of Health

Related topics

Related topics

11 relations
Adaptor Signaling Protein GeneGrowth Hormone Signaling PathwayIGF-1 Signaling PathwayIL4 Signaling Pathway

Broader (1)

Insulin Receptor Substrate Proteins

Papers overview

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2008
2008
Nitric oxide mediates the survival action of IGF-1 and insulin in pancreatic beta cells.
Generation of low levels of nitric oxide (NO) contributes to beta cell survival in vitro. The purpose of this study was to… 
2002
2002
GTK Tyrosine Kinase-induced Alteration of IRS-protein Signalling in Insulin Producing Cells
BackgroundInsulin receptor substrate proteins (IRS) mediate various effects of insulin, including regulation of glucose… 
2002
2002
PROTEIN TYROSINE PHOSPHATASE PTPL 1 / FAP-1 TRIGGERS APOPTOSIS IN HUMAN BREAST CANCER CELLS
2001
2001
Absence of insulin receptor substrate-1 expression does not alter GLUT1 or GLUT4 abundance or contraction-stimulated glucose uptake by mouse skeletal muscle.
The purpose of this study was to determine the influence of insulin receptor substrate-1 (IRS-1) expression on GLUT1 and GLUT4… 
Review
2000
Review
2000
IRS-1 variant: A new risk factor for coronary artery disease?
The genetic predisposition to develop coronary artery disease, while well established,1 2 3 is incompletely understood. Much… 
2000
2000
Insulin‐stimulated cardiac glucose uptake is impaired in spontaneously hypertensive rats: role of early steps of insulin signalling
Objective Although the heart is one of the target organs of insulin, it is still unknown whether the effect of insulin on cardiac… 
1998
1998
Codon 972 Polymorphism of the IRS-1 Gene is prevalent in Offspring of Subjects with Type 2 diabetes without Determining Clamp-derived Insulin Action
1997
1997
A 973 valine to methionine mutation of the human insulin receptor: interaction with insulin-receptor substrate-1 and Shc in HEK 293 cells
Summary A population-based study in the Netherlands has recently demonstrated that a mutation of the human insulin receptor (HIR… 
1996
1996
Insulin-like growth factor II activates mitogenic signaling in pancreatic cancer cells via IRS-1.
Insulin-like growth factor-II (IGF-II) action and expression were examined in 3 human pancreatic cancer cell lines. IGF-II… 
1994
1994
Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene
Nature 372, 186-190(1994) THE contents list in this (the 10 November) issue included a typographical error.