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inhibitor-of-apoptosis protein

Known as: Inhibitor of Apoptosis Protein, IAP Repeat Containing Proteins, Apoptosis Proteins Inhibitor 
A conserved class of proteins that control APOPTOSIS in both VERTEBRATES and INVERTEBRATES. IAP proteins interact with and inhibit CASPASES, and they… 
National Institutes of Health

Related topics

Related topics

29 relations
Apoptosis InhibitorBIR DomainBIRC2 protein, humanBIRC3 protein, human

Narrower (11)

BIRC5 protein, humanBIRC6 protein, humanBIRC6 protein, mouseBIRC7 protein, human

Broader (1)

Caspase Inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2014
Review
2014
Sensitization of melanoma cells for TRAIL-induced apoptosis by activation of mitochondrial pathways via Bax.
2013
2013
Double targeting of Survivin and XIAP radiosensitizes 3D grown human colorectal tumor cells and decreases migration.
Review
2006
Review
2006
Survivin: An inhibitor of apoptosis in pediatric cancer
Survivin is an inhibitor of apoptosis protein (IAP) expressed in a large number of adult malignancies. Its expression levels… 
Highly Cited
2005
Highly Cited
2005
Cisplatin activates Akt in small cell lung cancer cells and attenuates apoptosis by survivin upregulation
The inhibitor of apoptosis protein (IAP) survivin is overexpressed in many tumors but is absent in most normal adult tissues. We… 
Highly Cited
2004
Highly Cited
2004
Translation of cellular inhibitor of apoptosis protein 1 (c-IAP1) mRNA is IRES mediated and regulated during cell stress.
Cellular inhibitor of apoptosis protein 1 (c-IAP1) can regulate apoptosis through its interaction with downstream TNF receptor… 
Highly Cited
2004
Highly Cited
2004
Intramitochondrial serine protease activity of Omi/HtrA2 is required for caspase-independent cell death of human neutrophils
Intramitochondrial serine protease activity of Omi/HtrA2 is required for caspase-independent cell death of human neutrophils 
Highly Cited
2003
Highly Cited
2003
Silibinin down-regulates survivin protein and mRNA expression and causes caspases activation and apoptosis in human bladder transitional-cell papilloma RT4 cells.
2003
2003
Loss of inhibitor of apoptosis proteins as a determinant of polyamine analog-induced apoptosis in human melanoma cells
We have previously shown that the clinically relevant polyamine analog N1,N11-diethylnorspermine (DENSPM) causes rapid apoptosis… 
Highly Cited
2002
Highly Cited
2002
Morgue mediates apoptosis in the Drosophila melanogaster retina by promoting degradation of DIAP1
Inhibitor of apoptosis proteins (IAPs) provide a critical barrier to inappropriate apoptotic cell death through direct binding… 
Highly Cited
1999
Highly Cited
1999
Survivin’ cell-separation anxiety
Survivin, a cell-death inhibitor, localizes to the spindles of mitotic cells, and its absence causes both a failure in cell… 
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