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inhibitor-of-apoptosis protein
Known as:
Inhibitor of Apoptosis Protein
, IAP Repeat Containing Proteins
, Apoptosis Proteins Inhibitor
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A conserved class of proteins that control APOPTOSIS in both VERTEBRATES and INVERTEBRATES. IAP proteins interact with and inhibit CASPASES, and they…
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National Institutes of Health
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Related topics
Related topics
29 relations
Apoptosis Inhibitor
BIR Domain
BIRC2 protein, human
BIRC3 protein, human
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Narrower (11)
BIRC5 protein, human
BIRC6 protein, human
BIRC6 protein, mouse
BIRC7 protein, human
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Broader (1)
Caspase Inhibitors
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2014
Review
2014
Sensitization of melanoma cells for TRAIL-induced apoptosis by activation of mitochondrial pathways via Bax.
Sandra-Annika Quast
,
A. Berger
,
M. Plötz
,
J. Eberle
European Journal of Cell Biology
2014
Corpus ID: 29385422
2013
2013
Double targeting of Survivin and XIAP radiosensitizes 3D grown human colorectal tumor cells and decreases migration.
S. Hehlgans
,
Chrysi Petraki
,
Sebastian Reichert
,
N. Cordes
,
C. Rödel
,
F. Rödel
Radiotherapy and Oncology
2013
Corpus ID: 42950993
Review
2006
Review
2006
Survivin: An inhibitor of apoptosis in pediatric cancer
J. Fangusaro
,
Hugo Caldas
,
Yuying Jiang
,
R. Altura
Pediatric Blood & Cancer
2006
Corpus ID: 27970214
Survivin is an inhibitor of apoptosis protein (IAP) expressed in a large number of adult malignancies. Its expression levels…
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Highly Cited
2005
Highly Cited
2005
Cisplatin activates Akt in small cell lung cancer cells and attenuates apoptosis by survivin upregulation
L. Belyanskaya
,
S. Hopkins‐Donaldson
,
+5 authors
U. Zangemeister‐Wittke
International Journal of Cancer
2005
Corpus ID: 9641833
The inhibitor of apoptosis protein (IAP) survivin is overexpressed in many tumors but is absent in most normal adult tissues. We…
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Highly Cited
2004
Highly Cited
2004
Translation of cellular inhibitor of apoptosis protein 1 (c-IAP1) mRNA is IRES mediated and regulated during cell stress.
M. V. Van Eden
,
Marshall P Byrd
,
K. Sherrill
,
R. Lloyd
RNA: A publication of the RNA Society
2004
Corpus ID: 34899473
Cellular inhibitor of apoptosis protein 1 (c-IAP1) can regulate apoptosis through its interaction with downstream TNF receptor…
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Highly Cited
2004
Highly Cited
2004
Intramitochondrial serine protease activity of Omi/HtrA2 is required for caspase-independent cell death of human neutrophils
E. Blink
,
N. A. Maianski
,
E. Alnemri
,
A. Zervos
,
D. Roos
,
T. Kuijpers
Cell Death and Differentiation
2004
Corpus ID: 19206746
Intramitochondrial serine protease activity of Omi/HtrA2 is required for caspase-independent cell death of human neutrophils
Highly Cited
2003
Highly Cited
2003
Silibinin down-regulates survivin protein and mRNA expression and causes caspases activation and apoptosis in human bladder transitional-cell papilloma RT4 cells.
A. Tyagi
,
C. Agarwal
,
R. Singh
,
K. Shroyer
,
L. Glodé
,
R. Agarwal
Biochemical and Biophysical Research…
2003
Corpus ID: 21525607
2003
2003
Loss of inhibitor of apoptosis proteins as a determinant of polyamine analog-induced apoptosis in human melanoma cells
Ying Chen
,
D. Kramer
,
Fengzhi Li
,
C. Porter
Oncogene
2003
Corpus ID: 624519
We have previously shown that the clinically relevant polyamine analog N1,N11-diethylnorspermine (DENSPM) causes rapid apoptosis…
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Highly Cited
2002
Highly Cited
2002
Morgue mediates apoptosis in the Drosophila melanogaster retina by promoting degradation of DIAP1
R. Hays
,
L. Wickline
,
R. Cagan
Nature Cell Biology
2002
Corpus ID: 29848955
Inhibitor of apoptosis proteins (IAPs) provide a critical barrier to inappropriate apoptotic cell death through direct binding…
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Highly Cited
1999
Highly Cited
1999
Survivin’ cell-separation anxiety
John Calvin Reed
,
S. Reed
Nature Cell Biology
1999
Corpus ID: 35148934
Survivin, a cell-death inhibitor, localizes to the spindles of mitotic cells, and its absence causes both a failure in cell…
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