inhibitor-of-apoptosis protein

Known as: Inhibitor of Apoptosis Protein, IAP Repeat Containing Proteins, Apoptosis Proteins Inhibitor 
A conserved class of proteins that control APOPTOSIS in both VERTEBRATES and INVERTEBRATES. IAP proteins interact with and inhibit CASPASES, and they… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1995-2017
020406019952017

Related topics

Related topics

26 relations
Apoptosis InhibitorBIR DomainBIRC2 protein, humanBIRC3 protein, human
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Narrower (7)

BIRC5 protein, humanBIRC6 protein, humanBIRC6 protein, mouseBirc4 protein, mouse
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Broader (1)

Caspase Inhibitors

Related mentions per year

Related mentions per year

1936-2019
19401960198020002020
inhibitor-of-apoptosis protein
standards characteristics
physiological aspects
Caspase Inhibitors
Negative Regulation of Apoptosis
chemical synthesis

Papers overview

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Highly Cited
2004
Highly Cited
2004
Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP).
Akt negatively regulates apoptotic pathways at a premitochondrial level through phosphorylation and modulation of proteins such… (More)
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Highly Cited
2003
Highly Cited
2003
Elevated expression of inhibitor of apoptosis proteins in prostate cancer.
PURPOSE Inhibitor of apoptosis (IAP) family proteins are suppressors of apoptosis that have been implicated in apoptosis… (More)
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Highly Cited
2002
Highly Cited
2002
Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction.
To identify human proteins that bind to the Smac and caspase-9 binding pocket on the baculoviral inhibitor of apoptosis protein… (More)
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Highly Cited
2002
Highly Cited
2002
HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins.
Inhibitor of apoptosis (IAP) proteins inhibit caspases, a function counteracted by IAP antagonists, insect Grim, HID, and Reaper… (More)
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Highly Cited
2001
Highly Cited
2001
Livin, a novel inhibitor of apoptosis protein family member.
A novel human inhibitor of apoptosis protein (IAP) family member termed Livin was identified, containing a single baculoviral IAP… (More)
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Highly Cited
2001
Highly Cited
2001
Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death.
The inhibitor of apoptosis (IAP) family of anti-apoptotic proteins regulate programmed cell death and/or apoptosis. One such… (More)
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Highly Cited
2001
Highly Cited
2001
A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis
X-linked inhibitor-of-apoptosis protein (XIAP) interacts with caspase-9 and inhibits its activity, whereas Smac (also known as… (More)
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Highly Cited
1998
Highly Cited
1998
IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs.
Survivin is a member of the inhibitor of apoptosis protein (IAP) family. We investigated the antiapoptotic mechanism of Survivin… (More)
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Highly Cited
1997
Highly Cited
1997
Inhibition of reaper-induced apoptosis by interaction with inhibitor of apoptosis proteins (IAPs).
IAPs comprise a family of inhibitors of apoptosis found in viruses and animals. In vivo binding studies demonstrated that both… (More)
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Highly Cited
1995
Highly Cited
1995
The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins
The 75 kDa tumor necrosis factor receptor (TNFR2) transduces extracellular signals via receptor-associated cytoplasmic proteins… (More)
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