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A novel antisense oligonucleotide targeting survivin expression induces apoptosis and sensitizes lung cancer cells to chemotherapy.
Oligonucleotide 4003, which targets nucleotides 23-251 of survivin mRNA, was identified as the most potent compound and induced apoptosis and sensitized tumor cells to the chemotherapeutic agent etoposide.
Circulating DNA: a new diagnostic gold mine?
Inflammation-associated Cell Cycle–independent Block of Apoptosis by Survivin in Terminally Differentiated Neutrophils
- F. Altznauer, S. Martinelli, H. Simon
- Biology, MedicineThe Journal of experimental medicine
- 17 May 2004
Together, the findings demonstrate that survivin plays distinct and independent roles in the maintenance of the G2-M checkpoint and in apoptosis control, and its overexpression is not restricted to proliferating cells.
Antisense therapy for cancer--the time of truth.
Involvement of hTERT in apoptosis induced by interference with Bcl-2 expression and function
The results demonstrate that hTERT is involved in mitochondrial apoptosis induced by targeted inhibition of Bcl-2, and downregulation of endogenous h TERT protein by RNA interference markedly increased apoptosis inducement by both 4625 and HA14-1, while overexpression of wild-type hTERt blocked B cl-2-dependent apoptosis in a p53-independent manner.
Silencing of death receptor and caspase-8 expression in small cell lung carcinoma cell lines and tumors by DNA methylation
- S. Hopkins-Donaldson, A. Ziegler, R. Stahel
- Biology, ChemistryCell Death and Differentiation
- 1 March 2003
It is suggested that SCLC cells are highly resistant to apoptosis mediated by death receptors and that this resistance can be reduced by a combination of demethylation and treatment with IFNγ.
PEGylation and Multimerization of the Anti-p185HER-2 Single Chain Fv Fragment 4D5
- S. Kubetzko, Ela Balić, R. Waibel, U. Zangemeister‐Wittke, A. Plückthun
- Biology, ChemistryJournal of Biological Chemistry
- 17 November 2006
Both multimerization and PEGylation represent useful strategies to tailor the pharmacokinetic properties of therapeutic antibodies and their combined use can additively improve tumor targeting.
Induction of apoptosis and enhancement of chemosensitivity in human prostate cancer LNCaP cells using bispecific antisense oligonucleotide targeting Bcl‐2 and Bcl‐xL genes
To determine whether a specifically designed bispecific (Bcl‐2/Bcl‐xL) antisense oligonucleotide (ASO) induces apoptosis and enhances chemosensitivity in human prostate cancer LNCaP cells, as Bcl‐2…
High thermal stability is essential for tumor targeting of antibody fragments: engineering of a humanized anti-epithelial glycoprotein-2 (epithelial cell adhesion molecule) single-chain Fv fragment.
This is the first report of using a humanized anti-EGP-2 scFv in vivo for targeting solid tumors, which is a promising targeting moiety for the diagnostics and therapy of EGP-2-positive tumors in patients.
Bcl-2 and CCND1/CDK4 expression levels predict the cellular effects of mTOR inhibitors in human ovarian carcinoma
Molecular markers enabling the prediction of sensitivity/resistance to rapamycin may facilitate further clinical development of rapamycin and its derivatives as anticancer agents. In this study,…