Caspase Inhibitors

Known as: Caspase Blockers, Caspase Inhibitor, Blockers, Caspase 
Any substance that inhibits a caspase-family protease. Caspases play a key role in apoptosis as well as in inflammation and immune regulation… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1997-2017
010020030019972017

Papers overview

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Highly Cited
2011
Highly Cited
2011
The intracellular regulation of cell death pathways by cIAPs has been enigmatic. Here we show that loss of cIAPs promotes the… (More)
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Highly Cited
2004
Highly Cited
2004
Caspases play a central role in apoptosis, a well-studied pathway of programmed cell death. Other programs of death potentially… (More)
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Highly Cited
2003
Highly Cited
2003
In recent years, several inhibitors that prevent caspase activation and apoptosis have emerged. At high doses, however, these… (More)
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Highly Cited
2001
Highly Cited
2001
Survivin, an apoptosis inhibitor/cell-cycle regulator, is critically required for suppression of apoptosis and ensuring normal… (More)
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Highly Cited
2000
Highly Cited
2000
Sepsis induces lymphocyte apoptosis and prevention of lymphocyte death may improve the chances of surviving this disorder. We… (More)
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Highly Cited
2000
Highly Cited
2000
Mitochondria trigger apoptosis by releasing caspase activators, including cytochrome c (cytC). Here we show, using a pH-sensitive… (More)
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Highly Cited
1999
Highly Cited
1999
Release of cytochrome c is important in many forms of apoptosis. Recent studies of CD95 (Fas/APO-1)-induced apoptosis have… (More)
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Highly Cited
1998
Highly Cited
1998
Murine L929 fibrosarcoma cells treated with tumor necrosis factor (TNF) rapidly die in a necrotic way, due to excessive formation… (More)
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Highly Cited
1998
Highly Cited
1998
BACKGROUND Z-Val-Ala-Asp(OMe)-CH2F (ZVAD-fmk), a tripeptide inhibitor of the caspase interleukin-1beta-converting enzyme family… (More)
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Highly Cited
1997
Highly Cited
1997
In a cell-free apoptosis system, mitochondria spontaneously released cytochrome c, which activated DEVD-specific caspases… (More)
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