Corpus ID: 90731461

Matador and the Regulation of cyclin E1 in Normal Human Placental Development and Placental Pathology

  title={Matador and the Regulation of cyclin E1 in Normal Human Placental Development and Placental Pathology},
  author={J. Ray},
  • J. Ray
  • Published 2011
  • Biology
  • Preeclampsia and molar pregnancy are two devastating placental pathologies characterized by an immature proliferative trophoblast phenotype accompanied by excessive cell death. It is therefore of paramount importance to study the regulation of cell fate in the placenta, to gain a further understanding of the mechanisms that contribute to these diseases. In this dissertation we report that during normal placental development and in preeclampsia, Matador (Mtd), a pro-apoptotic member of the Bcl-2… CONTINUE READING
    2 Citations


    IFPA Trophoblast Research Award Lecture: the dynamic role of Bcl-2 family members in trophoblast cell fate.
    • 17
    • Highly Influential
    The role of apoptosis in the regulation of trophoblast survival and differentiation during pregnancy.
    • 239
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    Mtd/Bok takes a swing: proapoptotic Mtd/Bok regulates trophoblast cell proliferation during human placental development and in preeclampsia
    • 41
    • Highly Influential
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    Live and let die - regulation of villous trophoblast apoptosis in normal and abnormal pregnancies.
    • 100
    Effects of oxygen on cell turnover and expression of regulators of apoptosis in human placental trophoblast.
    • 91
    • Highly Influential
    Preeclampsia is associated with widespread apoptosis of placental cytotrophoblasts within the uterine wall.
    • 342
    Alteration of the Bcl-2 : Bax Ratio in the Placenta as Pregnancy Proceeds
    • 37
    Expression, Ontogeny, and Regulation of Hypoxia-Inducible Transcription Factors in the Human Placenta1
    • 159
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    Mechanism of Hypoxia-induced GCM1 Degradation
    • 53
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    A novel Mtd splice isoform is responsible for trophoblast cell death in pre-eclampsia
    • 72
    • Highly Influential
    • PDF