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imatinib

Known as: Imatinibum, 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide, Alpha-(4-methyl-1-piperazinyl)-3'-((4-(3-pyridyl)-2-pyrimidinyl)amino)-p-tolu-p-toluidide 
An antineoplastic agent that inhibits the Bcr-Abl fusion protein tyrosine kinase, an abnormal enzyme produced by chronic myeloid leukemia cells that… 
National Institutes of Health

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CGP 57148GleevecSTI571
Fusion Proteins, bcr-ablImatinib mesylateMast/Stem Cell Growth Factor Receptor Kit, humanNCIt Antineoplastic Agent Terminology

Papers overview

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2014
2014
Intracellular concentration of the tyrosine kinase inhibitor imatinib in gastrointestinal stromal tumor cells
Gastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm in the gastrointestinal tract. In most GISTs, the… 
2011
2011
Fibrosis, regeneration, and aging: playing chess with evolution.
In this issue of JASN , Iyoda et al. [1][1] report that administration of nilotinib, a second-generation inhibitor of cellular… 
2010
2010
Hemorrhagic colonic ulcers caused by dasatinib for chronic myelogenous leukemia
Dasatinib, a multi-kinase inhibitor that is active against BCR-ABL1 and SRC family kinases, has been reported to exert notable… 
2009
2009
Inibidores de tirosino quinase na leucemia mieloide crônica
A leucemia mieloide cronica (LMC) e uma neoplasia da medula ossea originada da translocacao entre os cromossomos 9 e 22 t(9:22… 
2009
2009
Fatal cerebral zygomycosis breakthrough in a patient with acute lymphoblastic leukemia on voriconazole prophylaxis after cord blood SCT
Fatal cerebral zygomycosis breakthrough in a patient with acute lymphoblastic leukemia on voriconazole prophylaxis after cord… 
2008
2008
Dasatinib or high-dose imatinib for patients with chronic myelogenous leukemia chronic-phase (CML-CP) resistant to standard- dose imatinib: 2-year follow-up data from START-R
7012 Background: Resistance to imatinib is a well-recognized problem in CML-CP. Dasatinib is 325-fold more potent than imatinib… 
2004
2004
Imatinib induces a cytogenetic response in blast crisis or interferon failure chronic myeloid leukemia patients with e19a2 BCR-ABL transcripts
Imatinib induces a cytogenetic response in blast crisis or interferon failure chronic myeloid leukemia patients with e19a2 BCR… 
2003
2003
Chromosomal abnormalities in Ph- cells of patients on imatinib.
The introduction of imatinib has been a major advance in the treatment of chronic myeloid leukemia (CML). Based on the results of… 
1976
1976
Urinary excretion of methaqualone-N-oxide in man.
1. Oral administration of therapeutic doses (250 mg) of methaqualone (Melsed) to adult human subjects gives rise to the urinary… 
1970
1970
Metabolic fate of 2-methyl-3-o-tolyl-4(3H)-quinazolinone. I. 2-nitrobenzo-o-toluidide as an urinary metabolite of 2-methyl-3-o-tolyl-4(3H)-quinazolinone in human.
2-Methyl-3-o-tolyl-4 (3H)-quinazolinone (MTQ) was orally administered to human, and its urinary metabolites were examined. Two…