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STI571

Known as: STI 571, STI-571 
National Institutes of Health

Related topics

Related topics

3 relations
Gleevec

Broader (2)

Imatinib mesylateimatinib

Papers overview

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Highly Cited
2005
Highly Cited
2005
Modulation of bone microenvironment with zoledronate enhances the therapeutic effects of STI571 and paclitaxel against experimental bone metastasis of human prostate cancer.
Prostate cancer cells metastasize to the bone where their interaction with osteoclasts and osteoblasts can lead to alterations in… 
2005
2005
Patupilone (epothilone B, EPO906) and imatinib (STI571, Glivec) in combination display enhanced antitumour activity in vivo against experimental rat C6 glioma
PurposeThe microtubule-stabilizing agent patupilone (epothilone B, EPO906) and the tyrosine kinase inhibitor imatinib (STI571… 
2004
2004
Liquid chromatographic method for detection and quantitation of STI-571 and its main metabolite N-desmethyl-STI in plasma, urine, cerebrospinal fluid, culture medium and cell preparations.
Review
2004
Review
2004
Mechanisms of Resistance to STI571 (Imatinib) in Philadelphia-chromosome Positive Acute Lymphoblastic Leukemia
Resistance against STI571 (Imatinib) appears to be multifactorial, but the most likely mechanisms can be broadly categorized as… 
2004
2004
Different roles of p38 MAPK and ERK in STI571‐induced multi‐lineage differentiation of K562 cells
STI571 is a specific tyrosine kinase inhibitor of Abl kinase. It was previously reported that STI571 induced hemoglobin synthesis… 
Highly Cited
2003
Highly Cited
2003
c‐Kit is preferentially expressed in MYCN‐amplified neuroblastoma and its effect on cell proliferation is inhibited in vitro by STI‐571
Coexpression for c‐Kit receptor and its ligand stem cell factor (SCF) has been described in neuroblastoma (NB) cell lines and… 
Highly Cited
2003
Highly Cited
2003
The reappraisal of gastrointestinal stromal tumors: from Stout to the KIT revolution
For five decades gastrointestinal stromal tumors (GISTs) truly have represented one of the most confusing as well as neglected… 
Highly Cited
2003
Highly Cited
2003
Imatinib mesylate (STI571) inhibits multiple myeloma cell proliferation and potentiates the effect of common antimyeloma agents
Summary.  c‐Kit has been shown to be mutated in several types of tumours, and its activity has been correlated with increased… 
Highly Cited
2002
Highly Cited
2002
Flavopiridol potentiates STI571-induced mitochondrial damage and apoptosis in BCR-ABL-positive human leukemia cells.
PURPOSE The goal of this study was to characterize interactions between the Bcr/Abl kinase inhibitor STI571 and the cyclin… 
2001
2001
Cotreatment with STI-571 enhances tumor necrosis factor alpha-related apoptosis-inducing ligand (TRAIL or apo-2L)-induced apoptosis of Bcr-Abl-positive human acute leukemia cells.
Bcr-Abl tyrosine kinase inhibitor STI-571 induces differentiation and apoptosis of HL-60/Bcr-Abl (with ectopic expression of p190… 
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