Fusion Proteins, bcr-abl

Known as: Bcr-Abl Tyrosine Kinase, BCR/ABL1 Fusion Protein, BCR/ABL Oncoprotein 
Translation products of a fusion gene derived from CHROMOSOMAL TRANSLOCATION of C-ABL GENES to the genetic locus of the breakpoint cluster region… (More)
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
Inhibition of BCR-ABL by imatinib induces durable responses in many patients with chronic myeloid leukemia (CML), but resistance… (More)
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Highly Cited
2004
Highly Cited
2004
Resistance to the ABL kinase inhibitor imatinib (STI571 or Gleevec) in chronic myeloid leukemia (CML) occurs through selection… (More)
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Highly Cited
2004
Highly Cited
2004
To better understand the origin of leukemic stem cells, we tested the hypothesis that all leukemia oncogenes could transform… (More)
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Highly Cited
2003
Highly Cited
2003
Clinical studies have shown that the tyrosine kinase inhibitor STI571 effectively controls BCR-ABL-positive chronic myelogenous… (More)
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Highly Cited
2002
Highly Cited
2002
Through sequencing analysis of blood or bone marrow samples from patients with chronic myeloid leukemia, we identified BCR-ABL… (More)
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Highly Cited
2001
Highly Cited
2001
BACKGROUND BCR-ABL is a constitutively activated tyrosine kinase that causes chronic myeloid leukemia (CML). Since tyrosine… (More)
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Highly Cited
2000
Highly Cited
2000
Targeting the tyrosine kinase activity of Bcr-Abl with STI571 is an attractive therapeutic strategy in chronic myelogenous… (More)
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Highly Cited
1998
Highly Cited
1998
Expression of the 210-kD bcr/abl fusion oncoprotein can cause a chronic myelogenous leukemia (CML)-like disease in mice receiving… (More)
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Highly Cited
1997
Highly Cited
1997
The Philadelphia chromosome found in virtually all cases of chronic myeloid leukemia (CML) and in about one third of the cases of… (More)
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Highly Cited
1996
Highly Cited
1996
HE PHILADELPHIA (Ph) chromosome was the first T chromosomal abnormality associated with a specific malignant disease in humans… (More)
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