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idelalisib

Known as: 5-Fluoro-3-phenyl-2-((S)-1-(9H-purin-6-ylamino)-propyl)-3H- quinazolin-4-one, 5-Fluoro-3-phenyl-2-((S)-1-(9H-purin-6-ylamino)-propyl)-3H-quinazolin-4-one, 5-fluoro-3-phenyl-2-[(1S)-1-(3H-purin-6-ylamino)propyl]quinazolin-4(3H)-one 
An orally bioavailable, small molecule inhibitor of the delta isoform of the 110 kDa catalytic subunit of class I phosphoinositide-3 kinase (PI3K… 
National Institutes of Health

Related topics

Related topics

10 relations

Broader (4)

Antineoplastic AgentsEnzyme InhibitorsPurinesQuinazolinones

Narrower (2)

CAL 101Zydelig
GS-1101Kinase Inhibitors [MoA]NCIt Antineoplastic Agent Terminologyidelalisib 150 MG Oral Tablet [Zydelig]

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Balancing early access with uncertainties in evidence for drugs authorized by prospective case series – systematic review of reimbursement decisions
To review clinical and cost‐effectiveness evidence underlying reimbursement decisions relating to drugs whose authorization… 
Review
2017
Review
2017
Idelalisib or Placebo in Combination with Bendamustine and Rituximab in Patients with Relapsed/Refractory CLL Interim Results of a Phase 3 Randomized, Double-blind Placebo-Controlled Trial
(BR) has been a standard of care for the management of patients with relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL… 
2017
2017
SAR study of 5-alkynyl substituted quinazolin-4(3H)-ones as phosphoinositide 3-kinase delta (PI3Kδ) inhibitors.
2016
2016
Spectroscopic Investigations and DFT Calculations on 3-(Diacetylamino)-2-ethyl-3H-quinazolin-4-one
The theoretical and experimental vibrational frequencies of 3-(diacetylamino)-2-ethyl-3H-quinazolin-4-one (2) were investigated… 
Highly Cited
2013
Highly Cited
2013
A phase II study of the selective phosphatidylinositol 3-kinase delta (PI3Kδ) inhibitor idelalisib (GS-1101) in combination with rituximab (R) in treatment-naive patients (pts) ≥65 years with chronic…
7005 Background: PI3K-delta is critical for activation, proliferation and survival of B cells and plays a role in homing and… 
2013
2013
Design and synthesis of some new quinazolin-4-(3H)-ones as anticonvulsant and antidepressant agents
A series of 3-[(4-substituted-benzylidene)-amino]-2-phenyl-3H-quinazolin-4-ones (5a–k) were synthesized by reacting 3-amino-2… 
2009
2009
Characterization and electrochemical studies of Mn(II), Co(II), Ni(II) and Cu(II) complexes with 2-mercapto-3-substituted-quinazolin-4-one and 1,10-phenanthroline or ethylenediamine as ligands.
2007
2007
Synthesis and pharmacological investigation of novel 3‐(3‐methylphenyl)‐2‐substituted amino‐3H‐quinazolin‐4‐ones as analgesic and anti‐inflammatory agents
A variety of novel 3‐(3‐methylphenyl)‐2‐substituted amino‐3H‐quinazolin‐4‐ones were synthesized by reacting the amino group of 2… 
2005
2005
Force field design and molecular dynamics simulations of the carbapenem- and cephamycin-resistant dinuclear zinc metallo-beta-lactamase from Bacteroides fragilis and its complex with a biphenyl…
On the basis of molecular dynamics simulations, we investigate the dynamic properties of the carbapenem- and cephamycin-resistant… 
Highly Cited
2002
Highly Cited
2002
Functional characterization of CP-465,022, a selective, noncompetitive AMPA receptor antagonist
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