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Kinase Inhibitors [MoA]

Known as: Kinase Inhibitors 
National Institutes of Health

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11 relations
Cobimetinibalectinibidelalisibkinase inhibitor

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
Practical Recommendations for Therapeutic Drug Monitoring of Kinase Inhibitors in Oncology
Despite the fact that pharmacokinetic exposure of kinase inhibitors (KIs) is highly variable and clear relationships exist… 
Highly Cited
2017
Highly Cited
2017
Novel Pieces for the Emerging Picture of Sulfoximines in Drug Discovery: Synthesis and Evaluation of Sulfoximine Analogues of Marketed Drugs and Advanced Clinical Candidates
Sulfoximines have gained considerable recognition as an important structural motif in drug discovery of late. In particular, the… 
Highly Cited
2017
Highly Cited
2017
Optimal sequencing of ibrutinib, idelalisib, and venetoclax in chronic lymphocytic leukemia: results from a multicenter study of 683 patients.
Background Ibrutinib, idelalisib, and venetoclax are approved for treating CLL patients in the United States. However, there is… 
Review
2016
Review
2016
Survival of patients with advanced metastatic melanoma: The impact of novel therapies.
Highly Cited
2016
Highly Cited
2016
High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells.
Novel agents such as the Bcl-2 inhibitor venetoclax (ABT-199) are changing treatment paradigms for chronic lymphocytic leukemia… 
Review
2016
Review
2016
Deregulation of the protein phosphatase 2A, PP2A in cancer: complexity and therapeutic options
The complexity of the phosphatase, PP2A, is being unravelled and current research is increasingly providing information on the… 
Highly Cited
2016
Highly Cited
2016
Effects of 31 FDA approved small-molecule kinase inhibitors on isolated rat liver mitochondria
The FDA has approved 31 small-molecule kinase inhibitors (KIs) for human use as of November 2016, with six having black box… 
Review
2016
Review
2016
Quinoxaline‐Based Scaffolds Targeting Tyrosine Kinases and Their Potential Anticancer Activity
Quinoxaline derivatives, also called benzopyrazines, are an important class of heterocyclic compounds. Quinoxalines have drawn… 
Review
2015
Review
2015
Aurora Kinase Inhibitors: Current Status and Outlook
The Aurora kinase family comprises of cell cycle-regulated serine/threonine kinases important for mitosis. Their activity and… 
Review
2010
Review
2010
Why do kinase inhibitors cause cardiotoxicity and what can be done about it?
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