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Cobimetinib

An orally bioavailable small-molecule inhibitor of mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), with potential antineoplastic activity… 
National Institutes of Health

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Cobimetinib 20 MG Oral Tablet [Cotellic]Kinase Inhibitors [MoA]NCIt Antineoplastic Agent Terminology

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Cotellic

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GDC-0973

Papers overview

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2019
2019
Extended 5-Year Follow-up Results of a Phase Ib Study (BRIM7) of Vemurafenib and Cobimetinib in BRAF-Mutant Melanoma
Purpose: To report the 5-year overall survival (OS) landmark and the long-term safety profile of vemurafenib plus cobimetinib… 
2018
2018
Abstract P5-21-01: Cobimetinib combined with paclitaxel as first-line treatment for patients with advanced triple-negative breast cancer (COLET study): Primary analysis of cohort I
Chemotherapy is the mainstay of treatment for triple-negative breast cancer (TNBC), but taxane resistance remains problematic… 
2017
2017
Atezolizumab (A) + cobimetinib (C) + vemurafenib (V) in BRAFV600-mutant metastatic melanoma (mel): Updated safety and clinical activity.
3063Background: Targeted inhibition of MEK with C and BRAF with V in BRAFV600-mutant mel can lead to both anticancer immune… 
2017
2017
Atezolizumab (A) + cobimetinib (C) in metastatic melanoma (mel): Updated safety and clinical activity.
3057Background: A, an anti–programmed death-ligand 1 (PD-L1) monoclonal antibody, inhibits PD-L1/programmed death-1 (PD-1) and PD… 
2017
2017
Preliminary Results from a Phase Ib Study Evaluating BCL-2 Inhibitor Venetoclax in Combination with MEK Inhibitor Cobimetinib or MDM2 Inhibitor Idasanutlin in Patients with Relapsed or Refractory (R…
Introduction: Effective treatment options for patients (pts) with R/R AML are limited and novel therapies are needed. Previous… 
2017
2017
Abstract CT107: A Phase Ib study to evaluate the MEK inhibitor cobimetinib in combination with the ERK1/2 inhibitor GDC-0994 in patients with advanced solid tumors
Background: Dysregulation of the MAPK pathway, initiated by mutations in the RAS or BRAF oncogenes or through upstream growth… 
Review
2016
Review
2016
The Systemic Management of Advanced Melanoma in 2016
Melanoma is a common type of skin cancer with a high propensity to metastasize. Tyrosine kinase inhibitors targeting the mitogen… 
2016
2016
Efficacy of cobimetinib (C) and vemurafenib (V) in advanced BRAF-mutated melanoma patients (pts) with poor and favorable prognosis in the coBRIM phase III study.
9530Background: In coBRIM, C+V significantly improved PFS and OS versus placebo (P)+V in pts with BRAFV600-mutated advanced… 
2015
2015
Extended follow-up results of phase Ib study (BRIM7) of vemurafenib (VEM) with cobimetinib (COBI) in BRAF-mutant melanoma.
9020 Background: BRIM7 formed the basis for development of the VEM + COBI regimen, which, in a randomized phase III trial… 
2015
2015
Use of Transgenic Mouse Models to Understand the Oral Disposition and Drug-Drug Interaction Potential of Cobimetinib, a MEK Inhibitor
Data from the clinical absolute bioavailability (F) study with cobimetinib suggested that F was lower than predicted based on its… 
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