Hypertrophic Scarring and Keloids: Pathomechanisms and Current and Emerging Treatment Strategies
- G. Gauglitz, H. Korting, T. Pavicic, T. Ruzicka, M. Jeschke
- MedicineMolecular Medicine
- 2011
The current understanding of the pathophysiology underlying keloid and hypertrophic scar formation is summarized and established treatments and novel therapeutic strategies are discussed.
CCL27–CCR10 interactions regulate T cell–mediated skin inflammation
- B. Homey, H. Alenius, A. Zlotnik
- Biology, MedicineNature Network Boston
- 1 February 2002
It is reported that most skin-infiltrating lymphocytes in patients suffering from psoriasis, atopic or allergic-contact dermatitis express CCR10, indicating that CCL27–CCR10 interactions have a pivotal role in T cell–mediated skin inflammation.
Adverse effects of topical glucocorticosteroids.
- U. Hengge, T. Ruzicka, R. Schwartz, M. Cork
- MedicineJournal of American Academy of Dermatology
- 2006
Skin cancers after organ transplantation.
- L. Kemény, T. Ruzicka
- MedicineNew England Journal of Medicine
- 7 August 2003
Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system.
- J. Reifenberger, M. Wolter, G. Reifenberger
- BiologyCancer Research
- 1 May 1998
The results indicate that both PTCH and SMOH represent important targets for genetic alterations in sporadic BCCs and PNETs.
IL-31: a new link between T cells and pruritus in atopic skin inflammation.
- E. Sonkoly, Anja Muller, B. Homey
- Medicine, BiologyJournal of Allergy and Clinical Immunology
- 1 February 2006
Cytosolic DNA Triggers Inflammasome Activation in Keratinocytes in Psoriatic Lesions
- Y. Dombrowski, M. Perić, J. Schauber
- BiologyScience Translational Medicine
- 11 May 2011
The authors found that the cathelicidin peptide LL-37, which has antimicrobial function, also served as an anti-inflammatory agent by blocking activation of the DNA-sensing inflammasome, providing new potential targets for the treatment of this chronic skin disease.
Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas
- J. Reifenberger, M. Wolter, G. Reifenberger
- Medicine, BiologyBritish Journal of Dermatology
- 1 January 2005
This study highlights the need to understand more fully the rationale behind the continued use of chemotherapy to treat basal cell carcinoma in women.
A role for Th1 and Th2 cells in the immunopathogenesis of atopic dermatitis.
- M. Grewe, C. Bruijnzeel-Koomen, J. Krutmann
- Medicine, BiologyImmunology today (Amsterdam. Regular ed.)
- 1 August 1998
Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells.
- R. Besch, H. Poeck, G. Hartmann
- BiologyJournal of Clinical Investigation
- 3 August 2009
An IFN-independent antiviral signaling pathway initiated by RIG-I and MDA-5 that activates proapoptotic signaling and, unless blocked by Bcl-xL, results in apoptosis is identified.
...
...